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Freedom Wares

@freedomwares

Patient advocate and Independent researcher of the Endocannabinoid System & Cannabinopathic Medicine for over 2 decades. Home grown and Internationally known. I.AM. Cannabian.

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22.12.2024
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Latest posts by Freedom Wares @freedomwares

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Cannabis Oil Ends Seizures in Drug-Resistant Epilepsy Cases Cannabis oil ends seizures, helping 19 patients with drug-resistant epilepsy reach seizure freedom and a new lease on life.

19 patients. 0 seizures.
This Canadian case series documents seizure freedom in every single patient with drug-resistant epilepsy, using #cannabis oil prescribed by licensed medical professionals.
๐Ÿ’œ Real outcomes. Real science. ๐Ÿ’œ
#CannabisOil #Epilepsy #SeizureFreedom #DrugResistantEpilepsy #DRE

04.06.2025 17:32 ๐Ÿ‘ 1 ๐Ÿ” 1 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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Alzheimerโ€™s Study: Intranasal CBD and Gene Delivery Works Alzheimerโ€™s treatment study shows intranasal Nano CBD targets brain plaques directly, offering noninvasive, gene-free therapeutic hope.

This study shows how Nano CBD, delivered via intranasal spray through smart PLGA nanoparticles, not only binds to amyloid beta plaques in the brain but also helps clear them, reducing neuroinflammation and offering a noninvasive, gene-free approach to treatment.
#AlzheimersDisease #PlaqueClearance

30.05.2025 10:55 ๐Ÿ‘ 0 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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CBD Depot Therapy for Triple-Negative Breast Cancer Relief CBD Depot Therapy offers new hope for TNBC with long-acting CBD implants that shrink tumors and reduce angiogenesis in models.

A single CBD injection shrank triple-negative breast cancer tumors by nearly 60% and blocked angiogenesis. No daily dosing required. This 2025 study shows long-acting CBD depot therapy could change how we treat TNBC. Real science, real hope.

#CBD #TNBC #CannabisScience #Oncology

13.05.2025 17:05 ๐Ÿ‘ 0 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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Conceptualizing Cannabis Harm Reduction: Lessons from BC Conceptualizing cannabis harm reduction through the lens of BCโ€™s compassion clubs and Ted Smithโ€™s enduring advocacy at VCBC.

Cannabis harm reduction didnโ€™t begin with policy. It began with people.
BCโ€™s compassion clubs like VCBC showed that care, dignity, and access come first.
Before legalization, they filled the gaps the system left behind.
We must remember who built the model and whoโ€™s still fighting to defend it.

04.05.2025 06:44 ๐Ÿ‘ 1 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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New Cannabis Compounds Target Neuroblastoma Cells New cannabinoids and cannabis compounds from cannabis flowers demonstrate strong antitumor activity against neuroblastoma.

Scientists have identified #Cannabielsoxa, a new #cannabinoid, along with chlorin-type metabolites among several other known #cannabinoids from #cannabis flowers, showing strong activity against #neuroblastoma cells. Showing promise in fighting neuroblastoma. A breakthrough in #cancer therapy.

27.04.2025 20:07 ๐Ÿ‘ 2 ๐Ÿ” 0 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 0
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Hemp Oil May Replace Antibiotics in Beef Hemp Oil May Replace Antibiotics as an antimicrobial alternative to antibiotics for cattle, offering new solutions in livestock health

Traditionally, antibiotics like tylosin and virginiamycin managed F. necrophorum in cattle. With rising concerns about resistance and gut health, new research shows hemp oilโ€™s cannabinoids, terpenes, and flavonoids could offer a safer, natural alternative.

#HempOil #AnimalHealth #Sustainability

26.04.2025 07:15 ๐Ÿ‘ 1 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0

๐Ÿ™Thank-you kindly for sharingโค๏ธ,
Dev

21.04.2025 05:49 ๐Ÿ‘ 1 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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Cannabinerolโ€™s Promise in Alzheimerโ€™s: Gene Repair Breakthrough Cannabinerolโ€™s Promise in Alzheimerโ€™s: New research reveals its potential to reverse gene splicing errors and protect brain cells

New study: CBNR, a rare #cannabinoid, may correct RNA splicing errors in #Alzheimerโ€™s. Not just symptom management but actually correcting some of the cellular programming gone awry. Findings hypothesize CBNR counteracts Aฮฒโ€™s effects, ultimately returning conditions to those of the control group.

20.04.2025 10:28 ๐Ÿ‘ 1 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0

If addiction to video games is essentially the same as addiction to heroin, then why aren't video games criminalized in the same way?

If it's completely different, then why do the same places offer treatment for both kinds of "addiction"?

13.04.2025 05:18 ๐Ÿ‘ 15 ๐Ÿ” 6 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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From Hemp to High-Tech: The Rise of Smart, Sustainable Paper From Hemp to High-Tech: The Rise of Smart, Sustainable Paper - A breakthrough material with heat, antibacterial, and sensor tech

From Hemp to High-Tech
What if paper could generate heat, detect humidity, & kill bacteria, all while being eco-friendly? A new hemp-based smart paper is changing the game in packaging, purification & beyond. #SmartPaper #Hemp #Sustainability #GreenTech #CleanEnergy #FutureOfPackaging
- is.gd/kqLj4h

14.04.2025 18:38 ๐Ÿ‘ 0 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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Hemp-Based Biocomposites: A Sustainable Alternative to Plastics Hemp-Based Biocomposites: Discover how hemp-based biocomposite films are revolutionizing eco-friendly, biodegradable materials

Discover the future of eco-friendly materials. Hemp-based biocomposites offer a sustainable, biodegradable alternative to plastic; impacting everything from packaging to biomedical use. Hemp, starch, and agar are changing the game...
#Bioplastics #Hemp #SustainableMaterials #EcoFuture
is.gd/50Q9VH

14.04.2025 18:26 ๐Ÿ‘ 1 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0

Holding you in my thoughts, Alison <3 Your strength has moved mountains before... ..you are not alone in this. Sending you all the love and light for answers, healing, and peace. Praying ๐Ÿ™
๐Ÿ€
- Dev, โœŒ๏ธ

07.04.2025 22:45 ๐Ÿ‘ 1 ๐Ÿ” 0 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 0
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Bioengineered Cannabinoids: Corporate Greed vs. Natural Healing As bioengineered cannabinoids emerge, we must ask ourselves: Are we compromising patientsโ€™ needs for the sake of corporate profits?

Scientists engineered algae to produce cannabinoid compounds. No cannabis plant is required. Eco friendly or just eerie? Would you take algae and genes over fields and buds?

Read more?: freedomwares.ca/bioengineere...

#KeepCannabisReal #WholePlantMedicine #CannabisScience #ProtectThePlant

07.04.2025 19:44 ๐Ÿ‘ 7 ๐Ÿ” 3 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
Post image

The #ECS plays a key role in brain function, and research suggests it may be dysregulated in autism. #Cannabis helps some patients by reducing neuroinflammation, improving neurotransmitter balance and easing anxiety, sensory issues and sleep disturbances.

#Autism research: tinyurl.com/2supr4a3

02.04.2025 18:41 ๐Ÿ‘ 2 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
Cannabidiol/tetrahydrocannabinol-enrich extract decreases neuroinfalmmation and improves locomotor outcome following spinal cord injury 

Neuroinflammation is one of the main players in lesion expansion and locomotor deficits after spinal cord injury (SCI), thus treatments to control the inflammatory process emerge as novel therapeutic strategies. In this context, the anti-inflammatory effects of tetrahydrocannabinol (THC) and cannabidiol (CBD), the main phytocannabinoids of Cannabis sativa, are increasingly recognized. The aim of this work was to investigate the effects of a standardized Cannabis sativa extract (CSE), which is mainly composed by THC/CBD in equimolar concentration, on neuroinflammation, secondary damage and locomotor outcome after SCI in rats. After acute SCI, CSE therapy increased the number of non-inflammatory (arginase-1 positive) microglial cells in the epicenter of the lesion and decreased the number of pro-inflammatory ones (arginase-1 negative) in the epicenter and in the rostral and caudal regions of the lesion. CSE also reduced the number of reactive astrocytes in the grey matter of the rostral and caudal regions. These results are consistent with the downregulation of mRNAs of inflammatory mediators (IL-1ฮฒ, TNFฮฑ, IL-6, C3) and the upregulation of anti-inflammatory markers (ARG-1, MRC). In the chronic phase, CSE treatment prevented cyst expansion and also increased the volume of spared grey and white matter. Regarding locomotor outcome, CSE-treated rats showed better locomotor scores (open field test), higher latency to fall (Rotarod test) and lower number of hindlimb foot misplacements (horizontal ladder walking test) than untreated injured rats. These results suggest that this standardized CSE offers a promising perspective for reducing acute neuroinflammation and promoting functional recovery after SCI.

Cannabidiol/tetrahydrocannabinol-enrich extract decreases neuroinfalmmation and improves locomotor outcome following spinal cord injury Neuroinflammation is one of the main players in lesion expansion and locomotor deficits after spinal cord injury (SCI), thus treatments to control the inflammatory process emerge as novel therapeutic strategies. In this context, the anti-inflammatory effects of tetrahydrocannabinol (THC) and cannabidiol (CBD), the main phytocannabinoids of Cannabis sativa, are increasingly recognized. The aim of this work was to investigate the effects of a standardized Cannabis sativa extract (CSE), which is mainly composed by THC/CBD in equimolar concentration, on neuroinflammation, secondary damage and locomotor outcome after SCI in rats. After acute SCI, CSE therapy increased the number of non-inflammatory (arginase-1 positive) microglial cells in the epicenter of the lesion and decreased the number of pro-inflammatory ones (arginase-1 negative) in the epicenter and in the rostral and caudal regions of the lesion. CSE also reduced the number of reactive astrocytes in the grey matter of the rostral and caudal regions. These results are consistent with the downregulation of mRNAs of inflammatory mediators (IL-1ฮฒ, TNFฮฑ, IL-6, C3) and the upregulation of anti-inflammatory markers (ARG-1, MRC). In the chronic phase, CSE treatment prevented cyst expansion and also increased the volume of spared grey and white matter. Regarding locomotor outcome, CSE-treated rats showed better locomotor scores (open field test), higher latency to fall (Rotarod test) and lower number of hindlimb foot misplacements (horizontal ladder walking test) than untreated injured rats. These results suggest that this standardized CSE offers a promising perspective for reducing acute neuroinflammation and promoting functional recovery after SCI.

Cannabidiol/tetrahydrocannabinol-enrich extract decreases neuroinfalmmation and improves locomotor outcome following spinal cord injury - tinyurl.com/zah9ydpz

#SpinalCordInjury(#SCI) #Neuroprotection #Cannabinoids #CannabisTherapy #NeuroScience #FunctionalRecovery #CBDTHCExtract #SCIRecovery

31.03.2025 18:55 ๐Ÿ‘ 0 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
Pilot Study on the Effect of Cannabidiol-Coated Fabric for Pillow Covers Improves the Sleep Quality of Shift Nurses

"Of the 55 participants, 10 were men (18.2%) and 45 were women (81.8%). At baseline, all participants exhibited poor sleep quality (PSQI โ‰ฅ 5). However, after three weeks of using CBD-coated pillow covers, subjective sleep quality significantly improved, with 7.3% of participants achieving PSQI scores <5. Additionally, slight changes in sleep patterns were observed, with increases in both light sleep and deep sleep durations. Light sleep duration increased from a baseline of 196.21 ยฑ 65.28 to 206.57 ยฑ 59.15 min two weeks after intervention (p = 0.337). Similarly, deep sleep duration showed a modest increase from 61.97 ยฑ 21.01 min to 64.35 ยฑ 22.19 min (p = 0.288). Furthermore, a significant reduction in anxiety levels was reported (p < 0.005)."

"Using a CBD-coated pillow cover was found to enhance sleep duration in healthy individuals experiencing poor sleep. Consequently, for adults struggling with sleep difficulties, incorporating a CBD-coated pillow cover may serve as an effective aid in improving sleep quality."
- https://freedomwares.ca/cbd-coated-fabric-for-pillow-covers-improves-shift-nurses-sleep/?fbclid=IwY2xjawJT2WNleHRuA2FlbQIxMAABHZyECYnnWdH6BsKQgCDvCVK7LG1AQe2jLCFOPoJU-qimtLQLhBe2zTkgHw_aem_ooKZGw42DB-C7NYv6ZSXkA

Pilot Study on the Effect of Cannabidiol-Coated Fabric for Pillow Covers Improves the Sleep Quality of Shift Nurses "Of the 55 participants, 10 were men (18.2%) and 45 were women (81.8%). At baseline, all participants exhibited poor sleep quality (PSQI โ‰ฅ 5). However, after three weeks of using CBD-coated pillow covers, subjective sleep quality significantly improved, with 7.3% of participants achieving PSQI scores <5. Additionally, slight changes in sleep patterns were observed, with increases in both light sleep and deep sleep durations. Light sleep duration increased from a baseline of 196.21 ยฑ 65.28 to 206.57 ยฑ 59.15 min two weeks after intervention (p = 0.337). Similarly, deep sleep duration showed a modest increase from 61.97 ยฑ 21.01 min to 64.35 ยฑ 22.19 min (p = 0.288). Furthermore, a significant reduction in anxiety levels was reported (p < 0.005)." "Using a CBD-coated pillow cover was found to enhance sleep duration in healthy individuals experiencing poor sleep. Consequently, for adults struggling with sleep difficulties, incorporating a CBD-coated pillow cover may serve as an effective aid in improving sleep quality." - https://freedomwares.ca/cbd-coated-fabric-for-pillow-covers-improves-shift-nurses-sleep/?fbclid=IwY2xjawJT2WNleHRuA2FlbQIxMAABHZyECYnnWdH6BsKQgCDvCVK7LG1AQe2jLCFOPoJU-qimtLQLhBe2zTkgHw_aem_ooKZGw42DB-C7NYv6ZSXkA

Pilot Study on the Effect of Cannabidiol-Coated Fabric for Pillow Covers Improves the Sleep Quality of Shift Nurses
- tinyurl.com/2tue247e

After 3 weeks using CBD pillow covers, participants experienced improved sleep quality, increased light and deep sleep, and a significant reduction in anxiety

28.03.2025 19:36 ๐Ÿ‘ 0 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
Antimicrobial Effects of Cannabidiol (CBD)-infused Lozenges against Streptococcus mutans in Oral Health

A recent clinical trial has unveiled the potential of CBD-infused lozenges in combating harmful bacteria linked to tooth decay. Researchers explored the effects of CBD on Streptococcus mutans, a key player in cavity formation. Over 15 days, participants in the experimental group consumed one 300 mg CBD lozenge daily, allowing it to dissolve for gradual absorption.

The results? A significant reduction in bacterial levels compared to the control group. This promising finding highlights CBDโ€™s antimicrobial properties and its potential role in improving oral health. 

This study opens doors to innovative CBD-based therapies for dental care, an exciting step forward in oral hygiene science.
- https://freedomwares.ca/antimicrobial-properties-of-cbd-lozenges/?fbclid=IwY2xjawJSyfFleHRuA2FlbQIxMAABHfxtrmxTwSO_cXVYvS3ONw_tdSjCsDgZKRO327_ycfYnC53piuTFaTqt-w_aem_ZDzZhvjACXDxAzYc32JGig
#Cannabidiol(#CBD) #OralHealth #DentalCare #StreptococcusMutans #Antimicrobial #CBDLozenges #DentalResearch #HealthyMouth #CBDHealth

Antimicrobial Effects of Cannabidiol (CBD)-infused Lozenges against Streptococcus mutans in Oral Health A recent clinical trial has unveiled the potential of CBD-infused lozenges in combating harmful bacteria linked to tooth decay. Researchers explored the effects of CBD on Streptococcus mutans, a key player in cavity formation. Over 15 days, participants in the experimental group consumed one 300 mg CBD lozenge daily, allowing it to dissolve for gradual absorption. The results? A significant reduction in bacterial levels compared to the control group. This promising finding highlights CBDโ€™s antimicrobial properties and its potential role in improving oral health. This study opens doors to innovative CBD-based therapies for dental care, an exciting step forward in oral hygiene science. - https://freedomwares.ca/antimicrobial-properties-of-cbd-lozenges/?fbclid=IwY2xjawJSyfFleHRuA2FlbQIxMAABHfxtrmxTwSO_cXVYvS3ONw_tdSjCsDgZKRO327_ycfYnC53piuTFaTqt-w_aem_ZDzZhvjACXDxAzYc32JGig #Cannabidiol(#CBD) #OralHealth #DentalCare #StreptococcusMutans #Antimicrobial #CBDLozenges #DentalResearch #HealthyMouth #CBDHealth

Antimicrobial Effects of CBD-infused Lozenges against Streptococcus mutans in Oral Health

This study opens doors to innovative CBD-based therapies for dental care, an exciting step forward in oral hygiene science.
- tinyurl.com/4wchdt2s

#CBD #DentalCare #StreptococcusMutans #Antimicrobial

28.03.2025 00:21 ๐Ÿ‘ 0 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
Development and Characterization of Cannabidiol Gummy Using 3D Printing

Revolutionizing Geriatric Care with 3D-Printed CBD Gummies 

These customizable CBD gummies, crafted using cutting-edge 3D printing technology, deliver precision dosing, improved elasticity, and optimized release.

Compared to traditional gummies, theyโ€™re designed to be gentler, effective, and more patient-friendly; perfect for addressing the unique needs of older adults with conditions like oropharyngeal dysphagia. 
Could this be the next big thing in personalized medicine? ๐Ÿค” 

#GeriatricCare #Dysphagia #CannabidiolGummy #Cannabidiol(#CBD)

Development and Characterization of Cannabidiol Gummy Using 3D Printing Revolutionizing Geriatric Care with 3D-Printed CBD Gummies These customizable CBD gummies, crafted using cutting-edge 3D printing technology, deliver precision dosing, improved elasticity, and optimized release. Compared to traditional gummies, theyโ€™re designed to be gentler, effective, and more patient-friendly; perfect for addressing the unique needs of older adults with conditions like oropharyngeal dysphagia. Could this be the next big thing in personalized medicine? ๐Ÿค” #GeriatricCare #Dysphagia #CannabidiolGummy #Cannabidiol(#CBD)

Development and Characterization of Cannabidiol Gummy Using 3D Printing

"Overall, 3D printing enables customizable CBD gummies with optimized release and offer a personalized and patient-friendly alternative to traditional oral forms for geriatric care."
- shorturl.at/DFqt2

27.03.2025 20:12 ๐Ÿ‘ 1 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
Editorial: Use of cannabis derivatives in veterinary medicine
Meme saying: "A growing body of evidence highlights the potential of cannabinoids as versatile therapeutic agents in veterinary medicine."

"In human medicine, the use of cannabis-derived products is increasing globally for a variety of indications, such as post-injury and back pain, chronic and neuropathic pain, sleeping disorders, multiple sclerosis, epilepsy and others (Klatzkow et al.). Veterinary medicine is dovetailing this trend with growing interest from clients and veterinarians for treating medical conditions in animals with these molecules."

This study supports the positive use of cannabis derivatives in veterinary medicine across multiple species, including dogs, cats, horses, and potentially even humans. Here are the key ways it helps:
- Pain Management: Cannabis derivatives like CBD show therapeutic potential in managing pain, including conditions like osteoarthritis.
- Epilepsy Treatment: Cannabinoids, particularly CBD, are studied for their efficacy in treating epilepsy in animals.
- Improved Bioavailability: Studies on different CBD formulations in dogs and cats suggest that specific preparations lead to better absorption and higher plasma concentrations.
- Long-Term Benefits: In horses, long-acting CBD formulations are shown to offer prolonged therapeutic effects, which is beneficial for consistent treatment.
- Species-Specific Efficacy: Research highlights that different species (e.g., dogs vs. cats) respond differently to cannabis products, emphasizing the need for tailored treatments.

These findings point to a growing interest and potential in using cannabis medicine across various species for treating chronic pain, epilepsy, and other conditions, although more research is needed for conclusive evidence.

Editorial: Use of cannabis derivatives in veterinary medicine Meme saying: "A growing body of evidence highlights the potential of cannabinoids as versatile therapeutic agents in veterinary medicine." "In human medicine, the use of cannabis-derived products is increasing globally for a variety of indications, such as post-injury and back pain, chronic and neuropathic pain, sleeping disorders, multiple sclerosis, epilepsy and others (Klatzkow et al.). Veterinary medicine is dovetailing this trend with growing interest from clients and veterinarians for treating medical conditions in animals with these molecules." This study supports the positive use of cannabis derivatives in veterinary medicine across multiple species, including dogs, cats, horses, and potentially even humans. Here are the key ways it helps: - Pain Management: Cannabis derivatives like CBD show therapeutic potential in managing pain, including conditions like osteoarthritis. - Epilepsy Treatment: Cannabinoids, particularly CBD, are studied for their efficacy in treating epilepsy in animals. - Improved Bioavailability: Studies on different CBD formulations in dogs and cats suggest that specific preparations lead to better absorption and higher plasma concentrations. - Long-Term Benefits: In horses, long-acting CBD formulations are shown to offer prolonged therapeutic effects, which is beneficial for consistent treatment. - Species-Specific Efficacy: Research highlights that different species (e.g., dogs vs. cats) respond differently to cannabis products, emphasizing the need for tailored treatments. These findings point to a growing interest and potential in using cannabis medicine across various species for treating chronic pain, epilepsy, and other conditions, although more research is needed for conclusive evidence.

Cannabis-derived products are growing globally in human and veterinary medicine for conditions like pain, epilepsy, and sleep disorders. This study supports their positive use in animals, including dogs, cats, and horses, with potential benefits for humans.

Read more: tinyurl.com/yu9dus4h

26.03.2025 20:21 ๐Ÿ‘ 2 ๐Ÿ” 1 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
Broiler chickens fed with Cannabis sativa residues show improved meat quality and nutrition without affecting growth. A natural feed additive with potential benefits for poultry farming.

Broiler chickens fed with Cannabis sativa residues show improved meat quality and nutrition without affecting growth. A natural feed additive with potential benefits for poultry farming.

Study finds that adding Cannabis sativa residues to broiler diets enhances meat flavor and nutrition without affecting growth. Higher CR levels increased amino acids and moisture while reducing fat. A promising natural feed additive! - freedomwares.ca/meat-quality...

#Poultry #SustainableFood

18.03.2025 02:23 ๐Ÿ‘ 1 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
A systematic study of molecular targets of cannabidiol in Alzheimerโ€™s disease

Background: Alzheimerโ€™s disease (AD) is a prevalent, incurable, and chronic neurodegenerative condition characterized by the accumulation of amyloid-ฮฒ protein (Aฮฒ), disrupting various bodily systems. Despite the lack of a cure, phenolic compounds like cannabidiol (CBD), a non-psychoactive component of cannabis, have emerged as potential therapeutic agents for AD.

Conclusions: In summary, the study indicates that CBD and its analogs reduce the production of Aฮฒ42. Overall, these findings support the potential of CBD in alleviating the underlying pathology and symptoms associated with AD, underscoring the crucial need for further rigorous scientific investigation to elucidate the therapeutic applications and mechanisms of CBD in AD.

A systematic study of molecular targets of cannabidiol in Alzheimerโ€™s disease Background: Alzheimerโ€™s disease (AD) is a prevalent, incurable, and chronic neurodegenerative condition characterized by the accumulation of amyloid-ฮฒ protein (Aฮฒ), disrupting various bodily systems. Despite the lack of a cure, phenolic compounds like cannabidiol (CBD), a non-psychoactive component of cannabis, have emerged as potential therapeutic agents for AD. Conclusions: In summary, the study indicates that CBD and its analogs reduce the production of Aฮฒ42. Overall, these findings support the potential of CBD in alleviating the underlying pathology and symptoms associated with AD, underscoring the crucial need for further rigorous scientific investigation to elucidate the therapeutic applications and mechanisms of CBD in AD.

A systematic study of molecular targets of cannabidiol in Alzheimerโ€™s disease - tinyurl.com/42w2kkck

#CBD & #Alzheimerโ€™s: Alzheimerโ€™s is a chronic, incurable disease linked to amyloid-ฮฒ buildup. Research suggests CBD, a non-psychoactive cannabis compound, may offer #neuroprotective benefits.

17.03.2025 02:26 ๐Ÿ‘ 2 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0

BlueSky may have deleted a post on me a bit ago. Is this common here? Does BlueSky censor cannabis related truths? I was told they would not. Fairly new to this network, still learning but still uncertain about it too...

20.02.2025 02:48 ๐Ÿ‘ 0 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
#Motherhood and medicinal #cannabis

"Mothers reported medicinal cannabis (MC) as an important facilitator of their ability to positively parent their children, enabling them to manage their own health needs (i.e., anxiety, endometriosis and arthritis). High costs of legal products hindered access to MC. Participants expressed unique risks that mothers face accessing the unregulated market for MC like being deemed a โ€˜bad motherโ€™ and losing custody of children. Stigma was countered with narratives of empowerment through proactive MC conversations with children and agency by self-medicating with MC despite the judgement they may face for being a parent that uses cannabis."

"Mothers felt managing their health with MC allowed them to be more present parents and better tolerate the stressors of motherhood. In-depth exploration of discussing MC with children and anticipating these conversations was a novel finding. Most mothers tried to destigmatise MC in conversations by classifying it in the same category as other medications and discussing its therapeutic benefits. Few were cautious about having these conversations too early."

#Motherhood and medicinal #cannabis "Mothers reported medicinal cannabis (MC) as an important facilitator of their ability to positively parent their children, enabling them to manage their own health needs (i.e., anxiety, endometriosis and arthritis). High costs of legal products hindered access to MC. Participants expressed unique risks that mothers face accessing the unregulated market for MC like being deemed a โ€˜bad motherโ€™ and losing custody of children. Stigma was countered with narratives of empowerment through proactive MC conversations with children and agency by self-medicating with MC despite the judgement they may face for being a parent that uses cannabis." "Mothers felt managing their health with MC allowed them to be more present parents and better tolerate the stressors of motherhood. In-depth exploration of discussing MC with children and anticipating these conversations was a novel finding. Most mothers tried to destigmatise MC in conversations by classifying it in the same category as other medications and discussing its therapeutic benefits. Few were cautious about having these conversations too early."

#Motherhood and medicinal #cannabis

"Mothers reported medicinal cannabis as an important facilitator of their ability to positively parent their children, enabling them to manage their own health needs (i.e., #anxiety, #endometriosis and #arthritis)."

Read more: tinyurl.com/559s7zxa

20.02.2025 02:43 ๐Ÿ‘ 1 ๐Ÿ” 1 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 0
Amyotrophic Lateral Sclerosis, the Endocannabinoid System, and Exogenous Cannabinoids: Current State and Clinical Implications
Online ahead of print.

"A unifying mechanistic cause for amyotrophic lateral sclerosis (ALS) remains uncertain. Multiple pathophysiological processes appear to occur simultaneously. Cannabinoids, including delta-9-tetrahydrocannabinol (THC), cannabidiol (CBD), cannabigerol (CBG), and others found in cannabis, and cannabis extracts (CEs), appear to have activity in these pathogenic pathways, which have led to increasing interest in cannabinoids as therapeutic agents for ALS. The use of cannabinoids as a treatment strategy is substantiated by preclinical evidence suggesting a role for the endocannabinoid system (ECS) in ALS and other neurodegenerative disorders."

"Preclinical data indicate that cannabis and CEs have powerful antioxidative, anti-inflammatory, and neuroprotective effects in the SOD1G93A mouse model of ALS. The use of CEs in SOD1G93A murine models has been shown to prolong neuronal cell survival, which leads to delayed onset of the disease state, and slows progression of the disease."

"Although research in humans remains limited, a few studies suggest that cannabis and CBD, in humans, provide benefits for both motor symptoms, including rigidity, cramps, and fasciculations, and non-motor symptoms including sleep quality, pain, emotional state, quality of life, and depression."

#AmyotrophicLateralSclerosis ( #ALS )
#EndocannabinoidSystem ( #ECS )
#ExogenousCannabinoids
#MotorNeuronDisease
#Neuroinflammation
#Neuromuscular
#Cannabinoids
#SleepQuality
#Pain
#EmotionalState
#QualityOfLife ( #QoL )
#More

Amyotrophic Lateral Sclerosis, the Endocannabinoid System, and Exogenous Cannabinoids: Current State and Clinical Implications Online ahead of print. "A unifying mechanistic cause for amyotrophic lateral sclerosis (ALS) remains uncertain. Multiple pathophysiological processes appear to occur simultaneously. Cannabinoids, including delta-9-tetrahydrocannabinol (THC), cannabidiol (CBD), cannabigerol (CBG), and others found in cannabis, and cannabis extracts (CEs), appear to have activity in these pathogenic pathways, which have led to increasing interest in cannabinoids as therapeutic agents for ALS. The use of cannabinoids as a treatment strategy is substantiated by preclinical evidence suggesting a role for the endocannabinoid system (ECS) in ALS and other neurodegenerative disorders." "Preclinical data indicate that cannabis and CEs have powerful antioxidative, anti-inflammatory, and neuroprotective effects in the SOD1G93A mouse model of ALS. The use of CEs in SOD1G93A murine models has been shown to prolong neuronal cell survival, which leads to delayed onset of the disease state, and slows progression of the disease." "Although research in humans remains limited, a few studies suggest that cannabis and CBD, in humans, provide benefits for both motor symptoms, including rigidity, cramps, and fasciculations, and non-motor symptoms including sleep quality, pain, emotional state, quality of life, and depression." #AmyotrophicLateralSclerosis ( #ALS ) #EndocannabinoidSystem ( #ECS ) #ExogenousCannabinoids #MotorNeuronDisease #Neuroinflammation #Neuromuscular #Cannabinoids #SleepQuality #Pain #EmotionalState #QualityOfLife ( #QoL ) #More

Amyotrophic Lateral Sclerosis, the Endocannabinoid System, and Exogenous Cannabinoids: Current State and Clinical Implications - tinyurl.com/4z4pzv7v

#AmyotrophicLateralSclerosis ( #ALS )
#EndocannabinoidSystem ( #ECS )
#NeuronalCellSurvival
#Cannabinoids
#QualityOfLife ( #QoL )

13.02.2025 20:01 ๐Ÿ‘ 0 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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Cannabidiol attenuates lipid metabolism and induces CB1 receptor-mediated ER stress associated apoptosis in ovarian cancer cells - Freedom Wares Our findings may provide a theoretical mechanism for anti-ovarian cancer using cannabidiol (CBD).

"Taken collectively, these data indicate that CBD may disrupt lipid metabolism, and lead to ER stress-related apoptosis in ovarian cancers. Our findings may provide a theoretical mechanism for anti-ovarian cancer using CBD." - tinyurl.com/yph69pce
#OvarianCancer #Cannabidiol ( #CBD)

08.02.2025 07:26 ๐Ÿ‘ 1 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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An asylum in Sungai Buloh used ganja to treat leprosy. It actually worked With Malaysia's tough stance on drugs nowadays, it's hard to believe that once upon a time, illegal substances such as cannabis and opium were widely consumed by the local populace. During the colonia...
01.02.2025 16:27 ๐Ÿ‘ 7 ๐Ÿ” 1 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0

Don't forget to make a few phone calls and send a few emails in support! We need community outrage against the raids to stop them from going on!

getyourdrugstested.com/help/

03.02.2025 04:32 ๐Ÿ‘ 4 ๐Ÿ” 3 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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How do restrictions on opioid prescribing, harm reduction, and treatment coverage policies relate to opioid overdose deaths in the United States in 2013โ€“2020? An application of a new state opioid poli... Identifying the most effective state laws and provisions to reduce opioid overdose deaths remains critical.Using expert ratings of opioid laws, we devโ€ฆ

"More robust state harm reduction policy scores were associated with reduced overdose risk, adjusting for other policy domains."

24.01.2025 17:26 ๐Ÿ‘ 1 ๐Ÿ” 1 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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โ€œSmoking weed it gets you over the humpโ€: Cannabis co-use as a facilitator of decreased opioid use among people who inject drugs in Los Angeles, California - Freedom Wares People who inject drugs described that cannabis co-use assisted in developing patterns of reduced opioid use in a number of ways...

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"Low barrier access to cannabis due to legalization facilitated co-using to decrease opioid use."

"Additional research from Vancouver, Canada reported a 16% increase in cessation of opioid injection linked to daily cannabis use."
freedomwares.ca/smoking-weed...

03.02.2025 20:35 ๐Ÿ‘ 0 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0