Plenty of Room - Newsletter

Yeah it's an interesting comparison! I like DNA as a scaffold, but proteins have amazing functionality!

AI-Designed Protein Nanoassembly: Molecular Lego's Next Frontier! AI-powered protein design creates modular nanostructures, transforming molecular engineering by unlocking protein building blocks that assemble like dynamic Lego components.

Can we play Lego using proteins? Oh yeah! With some help from machine learning 🧪🧬🖥️

Read how here! plentyofroom.beehiiv.com/p/ai-designe...

DNA Trash Cans: Outsmarting Tumor Signals with Origami Tech! DNA origami creates innovative "tumor traps" that capture cancer-signaling molecules, offering a groundbreaking approach to targeting and neutralizing uncontrolled cellular growth.

Can you use DNA traps to fight tumors?

This new work uses DNA origami nanostructures to capture TGF𝛽1, a cytokine involved in tumor growth and immune suppression. The system reduces tumor size and increases survival in mice! 🧪🖥️🧬

Read the whole breakdown here 👉 tinyurl.com/ytz7e7fr

AI-Powered Protein Dynamics: Decoding Hidden Molecular Movements! AI-powered protein dynamics: Machine learning decodes hidden molecular movements, revealing complex protein behavior through innovative computational techniques.

What do emus (yeah, the bird!) and protein dynamics have in common? 🧪

More than you would expect! Don't miss this cool work at the interface of AI and protein structures 😎

Read and subscribe 👉 plentyofroom.beehiiv.com/p/ai-powered...

DNA Plastics: Recyclable, Biodegradable Revolution! DNA and sugar chains create biodegradable, recyclable plastics, offering an innovative solution to global plastic pollution through groundbreaking molecular engineering.

400 million tonnes of plastic are produced each year, with tons of environmental problems.

Can DNA-based plastic be the solution? Super cool work! 🧪🖥️🧬

PS read and subscribe here 👉 plentyofroom.beehiiv.com/p/dna-plasti...

Synbio Breakthrough: Turning Plastic Bottles into Life-Saving Drugs! Synthetic biology transforms plastic waste into life-saving drugs, showcasing innovative chemistry that turns environmental challenges into medical breakthroughs.

Turning plastic waste into paracetamol, using bacteria? 😲 Is there something more sci-fi? 🧪

But yeah, now it's possible!
Read all about it here 👉👉 plentyofroom.beehiiv.com/p/synbio-bre...

AI Joins The Crispr Chat: AI Gene Editing Revolution! AI-powered CRISPR-GPT transforms gene editing, introducing a conversational AI co-pilot that makes genetic modification more accessible and intuitive for researchers.

Is AI joining the CRISPR chat?

CRISPR-GPT is a new AI-collaboration tool created to make the design of gene editing experiments as easy as possible!

Is this the future of science? 🤔🧪
Subscribe to get more like this plentyofroom.beehiiv.com/p/ai-joins-t...

AI-Powered Protein Dynamics: Decoding Hidden Molecular Movements! AI-powered protein dynamics: Machine learning decodes hidden molecular movements, revealing complex protein behavior through innovative computational techniques.

What do emus (yeah, the bird!) and protein dynamics have in common? 🧪

More than you would expect! Don't miss this cool work at the interface of AI and protein structures 😎

Read and subscribe 👉 plentyofroom.beehiiv.com/p/ai-powered...

AI-Designed Transmembrane Proteins: Glowing Cellular Membranes! AI design creates fluorescent transmembrane proteins, revealing cellular interactions through innovative molecular engineering and small molecule probes.

Light up the membrane! 💡🧪🧬🖥️

Transmembrane proteins are membrane gatekeepers, but designing new functional ones is hard.

This paper applies the power of ML to create transmembrane proteins that can bind small molecules and fluoresce 🏮

Read and subscribe! 👉 plentyofroom.beehiiv.com/p/ai-designe...

RFK Jr. in interview with Scripps News: ‘Trusting the experts is not science’ HHS Secretary RFK Jr. sat down with Scripps News for a wide-ranging interview, discussing mRNA vaccine funding policy changes and a recent shooting at the Centers for Disease Control and Prevention.

1. "'Trusting the experts is not a feature of either a science or democracy," Kennedy said."

It's literally a vital feature of both science and of representative democracy.

I've written a fair bit about trust in expertise as a vital mechanism in the collective epistemology of science.

AI-Powered Protein Dynamics: Decoding Hidden Molecular Movements! AI-powered protein dynamics: Machine learning decodes hidden molecular movements, revealing complex protein behavior through innovative computational techniques.

Emus and protein science?
Proteins are dynamic, but it's hard to study their transitions 🧪🖥️🧬

BioEmu uses machine learning to emulate protein dynamics with high precision and speed!

It complements simulations: first test with BioEmu, then continue with MD.

Read and subscribe tinyurl.com/enf5apzc

Is there something cooler than structural biology papers? 🧪🖥️🧬
Looking at RNA structures, of course! 😎
Do we know what these RNA nanocages do? No.
Are they cool? Yes.
Did they try to use them for drug delivery? Also yes.

Subscribe and get more like this at plentyofroom.beehiiv.com/p/rna-nanoca...

AI-Designed Protein Targeting: Taming Disordered Protein Chaos! AI-powered computational design unlocks disordered protein targets, transforming our understanding of flexible molecular structures and potential therapeutic approaches.

Some proteins like to fold in neat shapes, others enjoy chaos. Disordered proteins are considered "undruggable".

But today a new method creates binders using the power of computational methods! 🧪🖥️🧬

Subscribe to get more like this 👉 plentyofroom.beehiiv.com/p/ai-designe...

Yes it would be amazing to see more targeting of less organised proteins!

AI-Designed Protein Targeting: Taming Disordered Protein Chaos! AI-powered computational design unlocks disordered protein targets, transforming our understanding of flexible molecular structures and potential therapeutic approaches.

New issue is here 🎉

Some proteins like to fold in neat shapes, others enjoy chaos. Disordered proteins are considered "undruggable".

But today a new method creates binders using the power of computational methods! 🧪🖥️🧬

Subscribe to get more like this 👉 plentyofroom.beehiiv.com/p/ai-designe...

CRISPR-Based Data Storage: DNA Search Engine Revolution! CRISPR-Cas9 breakthrough: Innovative DNA data storage and retrieval method uses genetic engineering to transform digital information archiving.

Do you want to save your data in DNA? Well, now is coming closer!

This amazing work from University of Washington and Microsoft explore how to use CRISPR-Cas9 to access data in DNA databases. Cool! 🧪🧬🖥️

Read the whole breakdown here 👉 plentyofroom.beehiiv.com/p/crispr-bas...

AI RNA Design: Generating Functional Molecules with Machine Learning! AI RNA design: Advanced machine learning techniques create functional RNA molecules, from CRISPR guides to innovative toehold switches.

Is it possible to leverage AI to create functional RNAs?

Well, from now yes! 🧪
Subscribe to get more like this 👉 plentyofroom.beehiiv.com/p/ai-rna-des... #AI #biotech

Just in case you missed this super cool paper 😎🧪

Yes that's a huge problem!

Synbio Breakthrough: Turning Plastic Bottles into Life-Saving Drugs! Synthetic biology transforms plastic waste into life-saving drugs, showcasing innovative chemistry that turns environmental challenges into medical breakthroughs.

Bacteria turning plastic into drugs? Oh yeah!

Sometimes bacteria aren't enough to solve problems. What about merging biocompatible chemistry and bacteria to turn plastic bottles into paracetamol? 🧪🖥️🧬

Want to get more like this? Just subscribe! 👉 plentyofroom.beehiiv.com/p/synbio-bre...
#chemistry

Gene Editing Advancement: 200x Improvement in DNA Insertion! Gene editing revolution: Researchers develop advanced CRISPR-associated transposons, achieving 200x improvement in DNA insertion for genome modification.

Gene editing is moving from the lab to the clinic, but delivering gene-sized DNA is still a problem.

Today's paper evolved new CRISPR-associated transposons using phage-assisted evolution! 🧪

Subscribe to get more like this 👉 plentyofroom.beehiiv.com/p/gene-editi... #biotech #genomeediting

Computational Protein Design: Regenerative Medicine's Healing Future! Computational protein design revolutionizes regenerative medicine, engineering innovative biomaterials and scaffolds to guide tissue regeneration like sci-fi healing techniques.

What about merging protein design and regenerative medicine? This paper brings computationally designed proteins to guide tissue regeneration! 🧪

Subscribe to get more like this 👉 tinyurl.com/423u2pss #biotech #ML
#Ai

Don't miss this cool work! 🧪

AI Macrocycle Design: Revolutionizing Drug Discovery with Machine Learning! AI-powered protein design creates macrocycles, leveraging machine learning to generate novel drug candidates and transform molecular engineering approaches.

Finding new drugs is hard. Even more for macrocycles, the molecules that could be the new best thing in medicine!

🧪Enter RFpeptides, a machine learning pipeline for macrocycle binders! Great work from @uwproteindesign.bsky.social
Want more like this? 👉 tinyurl.com/2da2k8dy
#biotech #ML #AI 🧬🖥️

Computational Protein Design: Regenerative Medicine's Healing Future! Computational protein design revolutionizes regenerative medicine, engineering innovative biomaterials and scaffolds to guide tissue regeneration like sci-fi healing techniques.

Nothing to read on Sunday? I got you covered!

What about merging protein design and regenerative medicine? This paper brings computationally designed proteins to guide tissue regeneration! 🧪

Subscribe to get more like this 👉 tinyurl.com/423u2pss #biotech #ML
#Ai

Computational Protein Design: Regenerative Medicine's Healing Future! Computational protein design revolutionizes regenerative medicine, engineering innovative biomaterials and scaffolds to guide tissue regeneration like sci-fi healing techniques.

Protein design and regenerative medicine: is this the coolest duo?

Today, the authors used computationally designed proteins to guide tissue regeneration! Amazing work from @uwproteindesign.bsky.social and @upc.edu! 🧪🖥️🧬

Subscribe to get more like this 👉 tinyurl.com/423u2pss #biotech #ML
#Ai

Do you need something to fill the void until the next issue? 😎 Well, last week's is just here! 🧪 plentyofroom.beehiiv.com/p/gene-editi...

Very cool research! 🧪

New-to-nature biocompatible chemistry for plastic waste upcycling - Nature Chemistry Synthetic and biological chemistry are traditionally seen as separate fields. Now, a biocompatible chemical reaction enables an engineered microbe to convert plastic waste into valuable compounds unde...

Bacteria transforming plastics into paracetamol, insane! In all the good ways 🧪
www.nature.com/articles/s41...

AI Protein Sequencing Breakthrough: Decoding Peptides Faster! AI-powered protein sequencing: Instanovo uses advanced machine learning to decipher peptide structures, revolutionizing proteomics and biomedical research.

A big step forward for proteomics, especially in areas where reference data is scarce or unavailable.

It’s fast, powerful, and shows how AI can help wet lab biology in very real ways! 🧪

Read and subscribe to get more like this plentyofroom.beehiiv.com/p/ai-protein...