🚨 PRECOG 2.0 is live! 🚨
I’m thrilled to share a major expansion of PRECOG, now online @narjournal.bsky.social.
PRECOG 2.0 at a glance:
📊 335 cancer datasets
🧬 46,000+ total patients
🩺 ~55 distinct malignancies
📖 Read the Paper: lnkd.in/gyiXSmCM
🌐 Explore the Data: lnkd.in/gZDsDEyG
Now online in Cancer Discovery @aacrjournals.bsky.social: DNMT3A R882H Is Not Required for Disease Maintenance in Primary Human AML, but Is Associated with Increased LSC Frequency - by Thomas Köhnke, Daiki Karigane, Ravi Majeti, et al. doi.org/10.1158/2159... @stanfordmedicine.bsky.social
New #majetilab publication!
Asiri identifies 3 human MPP subsets from adult bone marrow and evaluates their engraftment + differentiation potential. Bonus: a single-cell multi-omics resource.
Check it out here ➡️ bit.ly/4mFSBEa
@stanforddeptmed.bsky.social @cp-cellreports.bsky.social
All clinical and expression data, along with cell type proportion associations with outcomes, are publicly available at precog.stanford.edu.
We integrated our existing pediatric data along with a newly curated ICI PRECOG resource into the PRECOG website, in addition to giving the site a UI overhaul.
Additionally, the recent advent of immune checkpoint inhibitor (ICI) therapies in cancer nominates novel biomarkers of clinical response, and prompted us to update PRECOG for the immunotherapy age.
Complimentary work from our group and others has provided similar expression-based biomarkers of outcomes in pediatric cancers (Pediatric PRECOG). However, this resource was never integrated into our online tool, limiting its accessibility and usefulness.
www.mdpi.com/2072-6694/13...
PRECOG has been a valuable resource for highlighting clinically relevant biomarkers across adult cancers. Additionally, it was one of the first comprehensive reports on the prognostic importance of the immune system in cancer.
www.nature.com/articles/nm....
Excited to share that, a decade after its initial release, PRECOG has an update!
www.biorxiv.org/content/10.1...
Looking forward to celebrating 80 years of federally funded science, technology and innovation @standupforscience.bsky.social SF, March 7, Civic Center, 1-3 pm 🧪 🧫 🧬
Happy to share a preprint from the Angelo lab many years in the making. Read on for a saga of multiplexed imaging, immunometabolism, and TB granulomas with some fun side quests into the realms of geographical information sciences and transcriptomics… (1/20) doi.org/10.1101/2025...
AI provides a universal framework that leverages data and compute at scale to uncover higher-order patterns
Today, @arcinstitute.org in collaboration with Nvidia releases Evo 2—a fully open source biological foundation model trained on genomes spanning the entire tree of life.
Excited to post my first #skySplain about our recent work published yesterday in Nature Genetics! www.nature.com/articles/s41.... One of the first authors of this study - Annika Vannan – actually wrote this breakdown, but she's not yet over here on bluesky and asked me to post!
I’m super excited to share what I’ve been working on for the last (many) years: a spatial + genomic + transcriptomic characterization of how the breast cancer microenvironment evolves through immunotherapy! (1/x) 🧪🧬 🖥️ #AcademicSky #MLSky #ImmunoSky www.biorxiv.org/content/10.1...
