Colorado RNA Club (@coloradornaclub)

The RNA Society & the Alliance for mRNA Medicines (AMM) are collaborating on communication & advocacy training for members on Mar. 6, 2-3pm ET (link below).

Please note: US federal law strictly prohibits US federal grantees from use of grant funds for lobbying & political activity.

04.03.2026 08:23 👍 3 🔁 2 💬 1 📌 0

Next week’s Slice of RNA features Johnathon Schafer, Remi Hoerr, and Katie Vaeth! Join us on Tuesday, March 10th, 1-3PM at @colorado.edu.
Please RSVP for pizza and carpool: docs.google.com/forms/d/e/1F...
Supported by @rnasociety.bsky.social, Lexogen and RNA Bioscience Anschutz.

03.03.2026 18:48 👍 3 🔁 1 💬 0 📌 0

We thank Mary Allen and @loverna.bsky.social for their engaging talks and the RNA community for the great discussion today at the Colorado–London RNA Joint Meeting. Thanks to @rnasociety.bsky.social for sponsoring this event. We look forward to more exciting talks and scientific exchange next year!

25.02.2026 18:30 👍 4 🔁 0 💬 0 📌 0

Join us on Wednesday!

23.02.2026 14:35 👍 1 🔁 1 💬 0 📌 0

Call for Abstracts
NEW-RNA Technologies in Biotech and Industry:
Innovations and Applications
www2.rnasociety.org/conferences/...

18.02.2026 00:55 👍 4 🔁 3 💬 0 📌 1

We’re excited to kick off 2026 with a joint meeting with the London RNA Club, featuring Mary Ann Allen and
@loverna.bsky.social!

🗓 Wednesday, February 25, 2026
⏰ 10:00 AM MST
📍 Zoom: please RSVP here for link: docs.google.com/forms/d/e/1F...

Supported by @rnasociety.bsky.social

03.02.2026 19:26 👍 6 🔁 4 💬 0 📌 2

Single-cell RNA sequencing reveals a quiescence-senescence continuum and distinct senotypes following chemotherapy | Nature Communications Quiescence (reversible cell-cycle arrest) and senescence (irreversible arrest) are challenging to distinguish due to a lack of specific biomarkers, yet both arise simultaneously after chemotherapy. While senescence suppresses tumors by limiting proliferation and recruiting the immune system, quiescent cancer cells evade future therapies and may resume proliferation. Here, we pair time-lapse imaging of cell-cycle dynamics with single-cell RNA sequencing after etoposide treatment to differentiate these states, linking heterogeneous cell-cycle phenotypes to the transcriptomic landscape. We identify diverse senescent types (senotypes) and link them to two arrest pathways — a gradual path arising after a standard mitosis-to-G0 transition, and an alternative direct path driven by a mitotic slip. Using pseudotime trajectory analysis, we find that senescent phenotypes begin to manifest early and gradually along the first trajectory, even in shallow quiescent cells. These data support a model wherein, following chemotherapy, quiescence and senescence exist on a continuum of cell-cycle withdrawal at a transcriptome-wide level. Quiescent and senescent cells often arise side by side after stress, yet their molecular relationship remains unclear. Here, the authors combine live-cell imaging and single-cell RNA sequencing to reveal a continuum of cell-cycle withdrawal.

Reduced protein biosynthesis distinguishes senescent from quiescent cells, and SASP expression is highest in cells that underwent mitotic slip (4N DNA content).
Sabrina Spencer is a highly esteemed colleague. @colorado.edu @natcomms.nature.com

doi.org/10.1038/s414... 🧪

2/2

29.12.2025 13:10 👍 3 🔁 2 💬 0 📌 0

Tom Cech to Davos: RNA research is 'still a big deal' The Nobel laureate and CU Boulder professor, recently ranked #1 globally for RNA research, will speak at the World Economic Forum annual meeting in Davos,

Nobel Laureate and Biochemistry Professor Tom Cech will deliver a talk this Wednesday at the World Economic Forum annual meeting in Davos, Switzerland. His message: RNA research is still a big deal. #WEF26

Tune in live ↓
https://bit.ly/4jPzvuN

20.01.2026 20:07 👍 11 🔁 6 💬 1 📌 1

Excited to share that this work is now published in its final form!

link.springer.com/article/10.1...

15.12.2025 14:37 👍 37 🔁 16 💬 2 📌 1

We are delighted to announce our next RNA Society Member Spotlight!
rnasociety.memberclicks.net/dr--neena-gr...

Dr. Grover is a Professor of Chemistry and Biochemistry at Colorado College, a private liberal arts college in Colorado Springs, USA.

11.12.2025 08:57 👍 6 🔁 2 💬 1 📌 0

Save the Date for RNA 2026 in Montreal, Canada!

14.10.2025 15:51 👍 5 🔁 3 💬 0 📌 0

Please nominate or apply for an RNA Society Award by October 20th!
www.rnasociety.org/awards

16.10.2025 09:01 👍 4 🔁 3 💬 0 📌 0

In this innate immunity focus issue, Roy Parker and colleagues discuss how condensation of pattern recognition receptors (PRRs) with foreign nucleic acids is regulated in innate immune activation. http://dlvr.it/TNkyJ0

17.10.2025 19:14 👍 8 🔁 2 💬 0 📌 0

Thinking about a PhD in Biology?
Join us for a virtual event where you can connect with faculty and graduate students from universities across Colorado!
Tuesday, Oct. 21st on Zoom from 1:30-3:00 PM. RSVP using the QR code to get access to a Zoom link.

17.10.2025 21:16 👍 2 🔁 1 💬 0 📌 0

We thank our speakers—Gabriel Galindo, Luisa Vasconcelos, and Dylan Parker—for sharing their exciting research at this week’s Slice of RNA at CU Anschutz!
Stay tuned for upcoming Colorado RNA Club events, and visit our LinkedIn page to stay connected:
www.linkedin.com/company/colo...

17.10.2025 20:52 👍 2 🔁 1 💬 0 📌 0

Colorado RNA Club

Latest posts by Colorado RNA Club @coloradornaclub