Siyuan Ding

My first graduate student so it is truly a milestone for our lab! @washumicrobiology.bsky.social

Congratulations to Juhee on a stellar thesis defense! Clear, thoughtful, and thorough. Your work on rotavirus and SARS-CoV-2 reflects incredible perseverance. It's been a privilege watching you grow into an independent scientist. Wishing you all the best in your next chapter!🎓👏

Great collaborations with lots of people including folks from the Sibley, Liu, Shen, and Dermody labs. @washumicrobiology.bsky.social @natcommag.bsky.social

Its function is highly conserved in multiple cell types including primary human intestinal epithelial cells and hepatocytes and many vertebrate species.

I presented part of this data at ASV2023 almost two years ago! Very happy to see it comes to fruition! Truly a heroic effort by Gaopeng.

SAMD9 senses cytosolic double-stranded nucleic acids in epithelial and mesenchymal cells to induce antiviral immunity Nature Communications - Sensing of cytosolic RNA or DNA can lead to innate responses, but little information is available for RNA/DNA dual sensors. Here the authors find SAMD9 as a potential dual...

We identified SAMD9 as a common sensor of cytosolic dsDNA and dsRNA molecules and a key host restriction factor of the infection of multiple dsRNA viruses in vitro and in vivo!
rdcu.be/eiJHa

Innate immune sensing of rotavirus by intestinal epithelial cells leads to diarrhea Hou et al. demonstrate in an infant mouse model that innate immune sensing of enteric viruses induces IFN-λ signaling, which downregulates an apical chloride exchanger that leads to increased intestin...

First post on Bluesky! Excited to share the first paper from our lab in 2025! cell.com/cell-host-mi.... Our study demonstrates that UV-inactivated replication-defective rotaviruses can cause diarrhea in neonatal mice, suggesting the host response also contributes to diarrhea to flush out the virus.