Dorothea Kossmann

Catalytic pKa Attenuation in a Hydrolytic Metalloenzyme by Genetic Code Expansion Hydrolytic metalloenzymes employ Lewis-acidic metal cofactors to activate water molecules, generating nucleophilic hydroxide species that facilitate catalysis. Their catalytic efficiency across a wide...

Still obsessed with histidine (and its mimics)! Our latest work from Benjamin 🎉 uses genetic code expansion—tuning the primary coordination sphere of a dizinc metallohydrolase—lowering the catalytic pKa and boosting activity up to 5x at acidic pH. Check it out! doi.org/10.1021/acs.biochem.5c00768

CouCy probes are an excellent scaffold for bacterial imaging and a promising tool for detecting phenotypic heterogeneity, which might allow unraveling the physiological state of resistant bacteria. By @dorotheakossmann.bsky.social and co-workers from the @locbp.bsky.social in JACS lnkd.in/eXMA_jWW

A Ratiometric pH Sensor for Gram-Positive and Gram-Negative Bacteria Fluctuating environments can lead to phenotypic heterogeneity within a monoclonal bacterial population, especially in response to antibiotics or the human immune system. Methods are required to analyz...

Congratulations to @dorotheakossmann.bsky.social! Her paper describing a novel sensor for bacterial pH just appeared online. Great collaboration with @ayaiizuka.bsky.social and Nina Khanna within the @nccr-antiresist.bsky.social! @chem.uzh.ch
pubs.acs.org/doi/10.1021/...

I‘m really happy that I had the opportunity to share my research at #ChemBioParis2025 and to have received this oral presentation prize!
Thanks to the #ICBS trainee symposium organisers for such a great start to the conference! @fychembio.fr

@locbp.bsky.social @chem.uzh.ch

A ratiometric pH sensor for Gram-positive and Gram-negative bacteria https://www.biorxiv.org/content/10.1101/2025.09.09.675137v1

Potent Inducers of Paraptosis through Electronic Tuning of Hemicyanine Electrophiles Paraptosis is a distinct form of programmed cell death characterized by cytoplasmic vacuolization, mitochondrial swelling, and endoplasmic reticulum (ER) dilation, offering an alternative to apoptosis...

Congrats to Juan! His discovery of hemicyanines as potent activators of paraptotic cell death has just been published! With great contributions from Jade (initial observations of ER swelling) and Craig (crucial supporting experiments)!
pubs.acs.org/doi/10.1021/...

The new issue of CHIMIA is out now!!!!

In this issue of CHIMIA, 17 recipients of the best oral & the best poster presentation awards at the Fall Meeting 2024 of the @swisschemistry.bsky.social have taken the opportunity to present their award winning research.  

#OPENACCESS #Switzerland #SCS

UZH: PhD position in Chemical Biology In the Laboratory of Chemical and Biological probes (PI: Pablo Rivera Fuentes), we do research at the interface of chemistry and biology, particularly in the fields of redox biology, development of im...

🚨Open PhD positions in chemical biology!🚨

Join us in developing chemigenetic probes for imaging and sensing.

⚗️🧫Experience in chemical synthesis and/or protein engineering?

🗻🇨🇭Love mountains, chocolate, and a safe, diverse, and engaging environment?

Apply (or re-post)!
jobs.uzh.ch/job-vacancie...