Stanley E. Strawbridge

Very similar gig at 123 Pleasant Street in Morgantown, WV, by Mustard Plug back in 2008/9ish. Much Skanking.

⏰ Deadline Approaching! ⏰
📅 15 January 2026

Under two weeks to apply for our fully funded PhD project “Engineering an in vitro human embryo implantation platform to study pathologies arising in early pregnancy” at @sheffielduni.bsky.social. #development #endometrium #materialsscience

The Company of Biologists Travelling Fellowships programme: a commitment to support the next generation of scientists ABSTRACT. Between 2008 and 2025, four of The Company of Biologists' journals – Development, Journal of Cell Science (JCS), Journal of Experimental Biology (JEB) and Disease Models & Mechanisms (DMM) –...

I strongly encourage ECRs to apply for opportunities like the Travelling Fellowships from the ever supportive @biologists.bsky.social

They are a fantastic for learning new skills, building collaborative networks, and honing scientific writing.

doi.org/10.1242/dev....

⏰ Deadline in two weeks! ⏰

Work at the interface of biology + computation to build a virtual human embryo to predict developmental success and failure.

Happy to answer questions!

🚨 Come join us @sheffielduni.bsky.social for a PhD on the evolution and development of feathers and flight! 🐣🔬

This project is supervised by @matt-towers.bsky.social & @alexgfletcher.bsky.social, and I'm excited to be involved as a project advisor. Please share!

www.findaphd.com/phds/project... 🧪

🚨 PhD Projects 🚨

We are advertising two UKRI funded PhD projects at the @sheffielduni.bsky.social. #stemcells #development #embryology #reproductivephysiology #mathmaticalmodelling #quantitativebiology

Do you make shipments?! I’d love this for the lab!

Finally, a career highlight, we made it into @cellysally.bsky.social 's #PaperThemeTune s:

bsky.app/profile/cell...

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Also, check out the behind-the-scenes interview on my path in science, a eureka moment, and what I do when I choose to leave the lab:

🎙️ doi.org/10.1242/dev....

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and thank you to funders:

@wellcometrust.bsky.social @biologists.bsky.social @ukri.org

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Thanks to co-authors & host institutions:

@scicambridge.bsky.social @pdncambridge.bsky.social @cam.ac.uk @drn-sheffield.bsky.social @sheffielduni.bsky.social @uoe-igc.bsky.social @edinburgh-uni.bsky.social @mskcancercenter.bsky.social @uniheidelberg.bsky.social @univparissaclay.bsky.social

[5/8]

To test this, we built a quantitative model of fate specification in the embryo. It predicts a two-step mechanism:

1️⃣ Physical exclusion
2️⃣ FGF4-driven fate bias

And it even works at the level of individual embryos!

[4/8]

Even ESCs lacking FGF4 can push host cells into the trophectoderm, just by outcompeting them for space. But with FGF4, they also bias host cells away from contributing to the embryo.

➡️ Crowding first, then signalling.

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When injected into 8-cell embryos, ESCs displace host cells from the future embryo into extra-embryonic tissues. This happens via physical crowding and, if the donor cells produce FGF4, also via molecular signalling.

[2/8]

🚨 New paper out in Development! 🚨

We show that donor embryonic stem cells (ESCs) reshape the developing mouse embryo, not just by what they signal, but where they push.

📄 doi.org/10.1242/dev....

[1/8]

I’ve been using my CoB insulated lunch bag for work ever since Biologist @ 100 in Liverpool! 🤓

10/10 Thanks to:
#MRC
@wellcometrust.bsky.social
#SãoPauloResearchFoundation
#JapanSocietyforthePromotionofScience #JSPS
#UEHARAMemorialFoundation

9/10 @drn-sheffield.bsky.social @sheffielduni.bsky.social @uoe-igc.bsky.social @edinburgh-uni.bsky.social @uniofaberdeen.bsky.social @uspoficial.bsky.social ‪@lsiexeter.bsky.social @exeter.ac.uk

8/10 Thank you to all the excellent people involved! (That I can find)
@lbates.bsky.social @tazami.bsky.social

Thanks to: @scicambridge.bsky.social @pdncambridge.bsky.social @babrahaminst.bsky.social @cambiochem.bsky.social @cam.ac.uk ...

7/10 Somatic versatility
Capacitated cultures then generate neuroectoderm, paraxial mesoderm & definitive endoderm with textbook marker profiles—ready for downstream lineage studies.

6/10 Forward Progression
10-day XAV capacitation guides naïve domes → primed flats—an in-vitro window on the pre- to post-implantation transition.

5/10 Extra-embryonic power
PD03 + A83 + Y → GATA3⁺ trophoblast cysts.
LIF + ACTIVIN + CHIR → hypoblast/ExEn. Use them for blastoids or placenta work.

4/10 Hallmark naïve identity
Lines keep the classic naïve signature, form domes in t2iLGöXYaa, and map to E5/6 epiblast by bulk RNA-seq.

3/10 Mosaicism in a dish
Two triplet sets showcase natural variation:
• 161.2A/C share a Chr2q deletion, 161.2B does not.
• 255.1B/C carry Chr5 trisomy, 255.1A does not.
Study how karyotype skews lineage choice—no embryos needed.

2/10 Multiple clones per embryo
Instead of one line per blastocyst, we expanded every dome-shaped colony. Result: single embryos now come with paired, triplet or quadruplet lines—perfect for side-by-side comparisons.

1/10🧵 New preprint! 🚀
We built a resource of 20 clonal human naïve pluripotent stem cell lines from 10 blastocysts. Explore embryo-to-embryo and clone-to-clone variation in one place.
👉doi.org/10.1101/2025.06.02.657331

Today’s speaker in our DRN external seminar series is Dr Thorsten Boroviak (PDN, University of Cambridge) @pdncambridge.bsky.social , who will talk on early embryonic development in primates.

Host: Anestis Tsakiridis @tsakiridis.bsky.social

All welcome!

Thanks to Anne Wiblin and the team at abcam for the invitation to share and discuss my research today! #stemcells #development

It was fantastic to have @lbates.bsky.social visit last week! Thank you for sharing your exciting work!

Exacerbated sonic hedgehog signalling promotes a transition from chemical pre-patterning of chicken reticulate scales to mechanical skin folding | Open Biology Many examples of self-organized embryonic patterning can be attributed to chemically mediated systems comprising interacting morphogens. However, mechanical patterning also contributes to the emergenc...

Check out our new research in @royalsocietypublishing.org's Open Biology! We experimentally induce a transition from chemical to mechanical patterning in the chicken embryo 🐣🔬 @lanevol.bsky.social 🧪

royalsocietypublishing.org/doi/10.1098/...