Kaden Southard

Congrats Fitzy this is so awesome!

Comprehensive transcription factor perturbations recapitulate fibroblast transcriptional states - Nature Genetics CRISPR activation of 1,836 human transcription factors recapitulates fibroblast transcriptional states observed in vivo and identifies regulators that can revert inflammatory states.

💫PUBLISHED @natgenet.nature.com

📰Comprehensive transcription factor perturbations recapitulate fibroblast transcriptional states.

By Kaden M. Southard, @normanlab.bsky.social and colleagues!

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www.nature.com/articles/s41...

A photo of a newly renovated science lab with metal cabinets and tile floors. Select pieces of equipment such as test tube racks and chairs are visible.

Excited to announce the opening of the @fitzsimmonslab.bsky.social at @michiganstateu.bsky.social dept. of biochemistry & molecular biology! (1/3)

Our paper is now out in final form at Nature Genetics! For those who missed the preprint, we used large-scale Perturb-seq targeting transcription factors to push primary fibroblasts into diverse transcriptional states, including those observed in cell atlas studies.

Comprehensive transcription factor perturbations recapitulate fibroblast transcriptional states Nature Genetics - CRISPR activation of 1,836 human transcription factors recapitulates fibroblast transcriptional states observed in vivo and identifies regulators that can revert inflammatory states.

rdcu.be/ezw15