💡Solving decades-long mysteries with cryoEM. 💥Brilliant science + best tech = life-saving medical research. Shaping the future of health through bold new approaches.
#ParkinsonsDisease
Disturbing reading: "Using mainly public funds, the scientific community paid the 5 large publishers $1.06 billion in 4 years. And according to this estimate, the sum covers only the fees to publish open access studies"
english.elpais.com/science-tech...
Professor Melanie Bahlo and Dr Fei Wang, from the WEHI Parkinson’s Disease Research Centre are part of an international team working to find a blood-based biomarker for Parkinson’s, funded by $1.77m from the Michael J. Fox Foundation.
www.wehi.edu.au/news/wehi-sc...
Scientific journals: we don’t want you using generative AI because it makes shit up.
Same journal: here is an AI summary or evaluation of this paper. This might be more useful than the actual abstract or paper that the authors freaking wrote
Same journal: AI cover art which makes no sense? Oooh!
Time to find out what’s the newest insight on the #ubiquitin-proteosome degradation system from our speakers: Shang-Te (Danny) Hsu, Yasushi Saeki, Indrajit Sahu, and Kylie Walters.
While this is our last talk session of Day 2 at #AusUb2025, science goes on at the poster session…
⏳Three days to go until #AusUb2025! What is Grant Dewson most looking forward to in the upcoming Ubiquitin Summit? 🤔 Perhaps the speakers? Perhaps the free coffee ☕️? Or perhaps the very British prospect of cloudy, sunless days at the beach☁️? Watch the video to find out!
⏳Four days to go until #AusUb2025! Check out the video below to hear some conference tips and tricks from our committee chair David Komander (and some potentially controversial interest rankings!?!?).
More interviews to come in the next few days so watch this space 😉
A poster advertising the Australian Ubiquitin Summit in Lorne from the 20th - 23rd of November. The logo of the conference, as well as a note that there is a Targeted Protein Degradation Day are displayed at the top of the poster. The rest of the poster contains a photo of the bay at Lorne, looking out from rock pools into the ocean. Sitting atop this image is a list of the invited speakers (available on the Lorne Ubiquitin website), and below a note that the meeting is being organised in conjunction with the International Symposium on Autophagy, held on the 16th - 20th of November.
📢 All ubiquitin aficionados! 📢
We are gearing up for the first Australian Ubiquitin Summit in three weeks 🤩🗓️
Are you ready for talking ubiquitin by the bay?
🗓️ 20-23 Nov
📍Mantra, Lorne, VIC
Chaired by David Komander (@komanderlab.bsky.social)
#AusUb2025
🔬 Exciting news for the ferroptosis community!
FerrOZtosis 2.0 symposium is happening this 19th September 2025 at The Florey, Melbourne.
📅 Abstract deadline: August 15
📍 Details & registration: lnkd.in/dn7imCzd
lithium ion trapped by beta-amyloid and the way to get around it
Could a metal ion supplement that cost pennies per day protect from Alzheimer's disease?
erictopol.substack.com/p/lithium-an...
🎉 What an honour to be a finalist in the 2025 Australian Museum Eureka Prizes for Scientific Discovery!! With David Komander, @zhongyangan.bsky.social, Alisa Glukhova and @nskirk.bsky.social.
Excited for the awards ceremony on Sept 3rd!
@eurekaprizes.bsky.social
@wehi-research.bsky.social
WEHI has formed a partnership with the Parkinson’s Research Foundation with one clear goal: to intensify the search for drug treatments to stop Parkinson’s.
Read more👇 www.wehi.edu.au/news/new-par...
NYT, Page One:
“Within hours, he had an email from China, offering to move his lab to ‘any city, any university I want,’ he said, with a guarantee of funding for the next 20 years.”
@nytimes.com
I am so excited to take part in the 2025 A Walk in the Park for Fight Parkinson's. The event is taking place on Sunday April 27th and I would love your support. Donate today so all those living with Parkinson's get the support they need to live a full life. www.awalkinthepark.org.au/s/2900/5275/t
Really nice step forward towards off-the-shelf DA cell therapies for Parkinson's.
Human brain cells engineered to evade detection by the immune system have successfully restored muscle control in a rat model of Parkinson’s disease
https://go.nature.com/4lqDT3w
Absolutely appalling!
You may have seen that the incoming NIH director and his buddies started a new journal, The Journal of the Academy of Public Health
(One clue: There is no recognized Academy of Public Health)
www.science.org/content/arti...
Absolute goosebump inducing visual!
sapper rush
Also research masonry to get better defence against infantry and cavalry units
Exciting news from the lab out today in Science - the structure of human PINK1 on a TOM-VDAC complex!
@wehi-research.bsky.social
More than 2 decades ago the PINK1 protein was found to be linked to Parkinson's disease, but its structure and how it was activated was not known. Until @science.org today. A triumph for cryo-EM and structural biology, introducing new targets for drug intervention.
www.science.org/doi/10.1126/...
Thrilled to share the structure of dimerised human PINK1 docked to an endogenous translocase array on the mitochondrial surface, composed of two TOM complexes, bridged by a VDAC2 dimer! Published today in Science www.science.org/doi/10.1126/...
@wehi-research.bsky.social @komanderlab.bsky.social
World-first: researchers have discovered what protein #PINK1 looks like in humans and how it is activated, solving a decades-long mystery in the fight against #Parkinsonsdisease. The team hope to use the knowledge to find a drug to stop #Parkinsons.
www.wehi.edu.au/news/scienti...
A Lancet Editorial: “American chaos: standing up for health and medicine”
“...to care is an act not of weakness, but of strength.”
The Lancet response: bit.ly/4jRb5Av
A new quality control mechanism for mitochondrial import from the Rapé lab! A Cullin E3 ligase binds TOM complexes and senses reductive stress. Really enjoyed writing a spotlight for this!
Spotlight: kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F...
Original article: www.cell.com/molecular-ce...
"The current knowledge of ubiquitin signals through a ubiquitin-centric, structural biology lens." Useful resource for ubiuitin-lovers.
www.cell.com/molecular-ce...
'Ubiquitin Lysine-Linkages' from the review 'Ubiquitin: a structural perspective' in Molecular Cell
New to #ubiquitin? Been with it for a while? Either way this review may be for you 🤩
Excited to share our review article in @molcell.bsky.social, diving deep into everything #ubiquitin
Read here 👉: kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F...
@cellpress.bsky.social
@wehi-research.bsky.social
