@potoyan
We are a curiosity-driven theoretical/computational biophysics lab at Iowa State University. Interested in biomolecular condensates, allostery, gene regulatory networks, chromatin, the origin of life, and RNA functions
Our RNA condensate work is finally out! Using simulations, we uncover the origin of the lower critical solution temperature (LCST) behaviour underlying thermo, iono-sensing functions in pure RNA condensates. www.pnas.org/doi/10.1073/...
A new paper shows how LCD sequence patterns encode condensate dynamics and material properties.
🔹 Periodic repeats → Elasticity-dominated
🔹 Disordered sequences → Viscosity-dominated
🔹 Minimum sticker spacing is crucial for fluidity, preventing transitions to glassy states.
doi.org/10.1371/jour...
In collaboration with @priya-r-banerjee.bsky.social we dive a little deeper into the microscopic interactions and sequence patterns that are shaping condensate activation energies pubs.acs.org/doi/10.1021/... For more context see also our prior work www.science.org/doi/10.1126/...