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Online now: Comparisons in microglial responses to ischemic–hypoxic #braininjury in neonatal and adult mice analyzed by transcriptome integration and deconvolution #technologies. doi.org/10.4103/ATN.... #Microglia #Neuroinflammation #Transcriptomics #SingleCell #StrokeResearch #MedSky #neuroskyence

Mahmoud et al. show that dual antiplatelet therapy (clopidogrel + aspirin) significantly reduces stroke recurrence and improves functional outcomes in older patients with mild-to-moderate ischemic stroke, but increases bleeding risk compared to aspirin alone. doi.org/10.4103/AGIN... #neuroskyence

Scolari & Granero show that #metalloantibiotics—transition metal complexes with antibiotics—offer a promising strategy to combat #osteomyelitis and enhance #bone regeneration by overcoming drug resistance and enabling local, sustained therapy. doi.org/10.4103/REGE... #Biomaterials #3DPrinting

Wu et al. review the dual role of nitric oxide in stroke—neuroprotective or neurotoxic depending on timing and dose—highlighting critical #therapeutic windows and the need for subtype-specific delivery strategies. doi.org/10.4103/mgr.... #StrokeResearch #NitricOxide #MedSky #neuroskyence

Online now:Dark white matter is a subcortical MRI marker in seizures and systemic disorders: A narrative review. doi.org/10.1016/j.ne... #DarkWhiteMatter #Neuroimaging #Epilepsy #MRI #Seizures #MOGAD #Neurology #Biomarker #MedicalResearch #BrainMRI #StatusEpilepticus #MedSky #neuroskyence

Chen et al. show that a time-squared augmented Lyapunov functional improves sampled-data #synchronization for chaotic neural networks, reducing conservatism and enhancing control precision. doi.org/10.4103/ATN.... #NeuralNetworks #NeuromorphicComputing #NonlinearDynamics #MedSky #neuroskyence

Correa et al. show that tropicamide, an M4 muscarinic receptor antagonist, reverses catalepsy and motor impairments in a haloperidol-induced mouse model of #Parkinson’s disease. doi.org/10.4103/AGIN... #Neuroscience #Tropicamide #MuscarinicReceptors #AgingResearch #MedSky #neuroskyence

Bokor & Fodor show that autologous retinal transplantation achieves high closure rates in refractory full-thickness macular holes, offering a promising solution for cases where standard surgery fails. doi.org/10.4103/REGE... #Ophthalmology #MacularHole #Vitrectomy #MedSky #neuroskyence

Chen et al. review how the #gasotransmitter hydrogen sulfide (H₂S) acts as a multitarget regulator to protect the brain, heart, kidney, liver, and lung from #ischemia-reperfusion injury by modulating inflammation, oxidative stress, and cell death pathways. doi.org/10.4103/mgr.... #H2S #MedSky

Kumar et al. review how #neurobiomarkers like glutathione, amyloid-β, and PD-L1 are driving new diagnostic and therapeutic strategies for #Alzheimer's, #Parkinson's, and glioblastoma. doi.org/10.1016/j.ne... #Neurology #GeneTherapy #Nanomedicine #BrainResearch #NeuroMarkers #MedSky #neuroskyence

Zhao et al. show that combining machine learning with #miRNA #biomarkers can diagnose epilepsy with up to 95.45% accuracy, offering a promising non-invasive alternative to traditional EEG methods. doi.org/10.4103/ATN.... #EpilepsyResearch #MachineLearning #Neurology #MedTech #MedSky #neuroskyence

Liu et al. review how animal-derived #peptides — from scorpion venom to deer antler velvet—show promise in combating aging-related diseases like tumors, thrombosis, diabetes, and #neuroaging. doi.org/10.4103/AGIN... #AgingResearch #TraditionalChineseMedicine #MedSky #neuroskyence #DrugDiscovery

Zhang et al. show that Sanghuang, a traditional medicinal fungus, may ameliorate #liverinjury and promote #regeneration by targeting multiple pathways including HIF-1α and MAPK signaling. doi.org/10.4103/REGE... #TraditionalChineseMedicine #NetworkPharmacology #MolecularDocking #MedSky #neuroskyence

Hu et al. show that sevoflurane postconditioning alleviates cognitive impairment after hemorrhagic shock and resuscitation by activating the SIRT1/HIF-1α/NLRP3 pathway. doi.org/10.4103/mgr.... #AnestheticGas #Sevoflurane #CognitiveImpairment #Neuroprotection #MedicalResearch #MedSky #neuroskyence

Silva et al. review how #aging impairs hippocampal #neurogenesis through serotonergic system dysfunction, and demonstrate that #aerobicexercise effectively counteracts these effects by modulating 5-HT activity and promoting #brain plasticity. doi.org/10.1016/j.ne... #Neuroscience #neuroskyence

Zhou et al. review how #brainorganoids— including vascularized, tumor, and #neurodegenerative models—are revolutionizing the study of #cerebrovascular diseases, brain tumors, and disorders like #Alzheimer's and #Parkinson's. doi.org/10.4103/ATN.... #Neuroscience #Glioblastoma #StemCells #Biomedical

Chen reviews how gamma oscillations shift with #aging and shows that gamma entrainment— tailored to an individual’s natural frequency—could serve as both an early #biomarker and a non-invasive therapy to preserve cognitive function and delay #neurodegeneration. doi.org/10.4103/AGIN... #Neurology

Shah et al. show that shorter #cardiopulmonary bypass and cross-clamp times—and the need for balloon atrioseptostomy—are associated with developmental delay in neonates after #arterialswitch operation for transposition of the great arteries. doi.org/10.4103/REGE... #Neurodevelopment #MedSky

Sevoflurane #postconditioning alleviates cognitive impairment after hemorrhagic shock by activating the SIRT1/HIF-1α/NLRP3 pathway. doi.org/10.4103/mgr.... #Sevoflurane #CognitiveImpairment #HemorrhagicShock #Neuroprotection #SIRT1 #HIF1α #NLRP3 #MedicalResearch #Anesthesia #MedSky #neuroskyence

New study by Zhang et al. identifies four long non-coding RNAs in blood as promising biomarkers for diagnosing major depression and predicting treatment response. doi.org/10.1016/j.ne... #Depression #Biomarkers #lncRNA #MentalHealth #Neuroscience #Research #Psychiatry #RNA #MDD #MedSky #neuroskyence

Machine learning combined with resting-state EEG enhances diagnostic accuracy for psychiatric disorders, offering a path toward objective biomarkers.
doi.org/10.4103/ATN.... #MachineLearning #EEG #Psychiatry #Biomarkers #MentalHealth #AI #Neuroscience #MedSky #neuroskyence

#AI-powered detection of cellular #Senescence is revolutionizing #Aging research! AUTHORS show that artificial intelligence enables accurate identification and quantification of senescent cells through advanced imaging and #DeepLearning models. doi.org/10.4103/AGIN... #Biomarkers #Longevity #MedSky

New study finds K-wire fixation yields better functional outcomes for olecranon fractures compared to screw-based #TensionBandWiring. doi.org/10.4103/REGE... #OlecranonFracture #KirschnerWire #CancellousScrew #OrthopedicSurgery #TraumaCare #FunctionalRecovery #FractureFixation #SurgicalOutcomes

CT-guided oxygen-ozone injection offers superior long-term pain relief and functional recovery for lumbar disc herniation with spinal stenosis compared to epidural steroids. doi.org/10.4103/mgr.... #OzoneTherapy #MinimallyInvasive #SpinalHealth #PainRelief #MedicalResearch #MedSky #neuroskyence

Study finds cataracts are associated with an increased risk of Parkinson’s disease, suggesting they may serve as a potential non-motor marker. doi.org/10.1016/j.ne... #ParkinsonsDisease #Cataract #Neurodegeneration #Biomarker #UKBiobank #ObservationalStudy

Shu et al. found that downregulation of #microtubule proteins TUBB2A, TUBB3, and TUBB4B contributes to #neuronaldysfunction in #Alzheimer’s disease by impairing microtubule stability and promoting tau pathology. doi.org/10.4103/AGIN... #Tubulin #Neuroscience #Bioinformatics #ADresearch #Aging

New technologies for improving the accuracy of #Neuroimaging: A stochastic Gaussian-masked #denoiser significantly enhances the visualization of subcellular structures and neural dynamics without requiring training data. doi.org/10.4103/ATN.... #Neuroscience #Microscopy #CalciumImaging #Bioimaging

New research using NHANES data finds that higher relative fat mass (RFM) is negatively associated with lumbar bone mineral density in U.S. adults aged 20–59. doi.org/10.4103/REGE... #Osteoporosis #BoneHealth #RFM #NHANES #Obesity #PublicHealth #RegenerativeMedicine

Liu et al. present a bibliometric and scientific mapping analysis of AI-driven nitric oxide clinical applications, highlighting knowledge gaps and translational challenges. doi.org/10.4103/mgr.... #ArtificialIntelligence #NitricOxide #MedicalAI #Bibliometrics #ClinicalResearch

Li et al. reviewed the roles of circular RNAs at synapses and their potential as biomarkers for neurological disorders. doi.org/10.1016/j.ne... #circRNA #Synapse #Biomarkers #Neurodegeneration #Alzheimers #Neuroscience #BrainResearch