Patrice D. Cani

Meta-analysis of the uncultured gut microbiome across 11,115 global metagenomes reveals a candidate signature of health Silva et al. perform a global analysis of over 11,000 gut microbiomes and reveal that uncultured bacteria are key markers of gut health. The uncultured genus CAG-170 is strongly linked to low gut dysb...

#NatMicroPicks

A microbial signature of health! 🦠⚕️

A large meta-analysis highlights the importance of previously unknown and uncultured gut bacteria in maintaining human health

#MicroSky

www.cell.com/cell-host-mi...

Hexokinase detachment from mitochondria drives the Warburg effect to support compartmentalized ATP production - Nature Metabolism Hexokinase detachment from the outer mitochondrial membrane is shown to support aerobic glycolysis in cancer cells. Differential localization of the HK1 isoform to the outer mitochondrial membrane, compared to the HK2 isoform, explains the conditional essentiality of HK2 in cancer cells cultured in physiologic media.

RESEARCH
@thebiokimist.bsky.social
@jasonrcantor.bsky.social

Differential localization of hexokinase HK1 explains the conditional essentiality of HK2 in cancer cells in physiol. media🧪

Dysosmobacter welbionis is a recently discovered butyrate producer

@microbesity.bsky.social et al. reveal that the inositol-to-butyrate pathway is conserved across species, reinforcing its ecological and therapeutic relevance

via #GutBMJ-@bmj.com

https://loom.ly/y2y_STg

🦠 Des chercheurs de l'UCLouvain ont découvert que la bactérie Dysosmobacter welbionis convertit le myo-inositol en butyrate, essentiel pour la santé intestinale et métabolique. Une avancée prometteuse pour ceux intolérants aux fibres fermentescibles. #Santé #Microbiote

Il batterio intestinale Dysosmobacter welbionis potrebbe aiutare a prevenire malattie metaboliche come diabete e fegato grasso Uno studio internazionale, a cui ha partecipato anche l’Italia, ha identificato un batterio intestinale che potrebbe aiutare a prevenire malattie metaboliche come diabete, obesità e fegato grasso. La…

🔵 Uno studio internazionale, a cui ha partecipato anche l’Italia, ha identificato un batterio intestinale (Dysosmobacter welbionis) che potrebbe aiutare a prevenire malattie metaboliche come diabete, obesità e fegato grasso
fonteufficiale.it/breaking-new...

Découverte majeure au cœur du microbiote intestinal Des chercheurs de l’UCLouvain et de huit pays européens ont identifié une bactérie intestinale humaine capable de transformer un nutriment végétal en une molécule essentielle au bon fonctionnement de…

#Santé La bactérie Dysosmobacter welbionis est capable de convertir le myo-inositol, un nutriment naturellement présent dans les fruits, céréales complètes, noix et légumineuses, en butyrate. L'étude a utilisé des souris.

Batterio intestinale Dysosmobacter welbionis: alleato contro malattie metaboliche Studio internazionale con partecipazione italiana rileva il ruolo protettivo del batterio per il fegato e il metabolismo Potrebbe essere un batterio intestinale l’inaspettato alleato nella prevenzione e nella gestione delle malattie metaboliche. A rivelarlo è uno studio internazionale pubblicato sulla rivista Gut, che ha visto la partecipazione di ricercatori italiani del Cnr-Ispaam di Portici, dell’Università […]

Batterio intestinale Dysosmobacter welbionis: alleato contro malattie metaboliche

Where are we with targeting gut-brain communication to manage diseases?

This timely review delves into advances in this fascinating area of research
https://www.jci.org/articles/view/196346

Dietary restriction reprograms CD8+ T cell fate to enhance anti-tumour immunity and immunotherapy responses - Nature Metabolism Dietary restriction promotes the expansion of effector T cells via ketone bodies, which enhances anti-tumour immunity and synergizes with immunotherapy in mice.

RESEARCH | BM Oswald, RG Jones @vai.org

Dietary restriction promotes expansion of effector T cells via ketone bodies, enhancing anti-tumour immunity & synergy with immunotherapy in mice 🧪

Shaping the future of cardiometabolic innovation: advances and opportunities - Nature Metabolism Obesity is a global public health concern closely linked to cardiometabolic complications. This Comment provides our views on recent breakthroughs, emerging innovations and future needs of therapeutic interventions to counteract obesity and its associated health risks.

#Throwback 🧪

COMMENT | Shaping the future of cardiometabolic innovation: advances and opportunities

@clemmensenc.bsky.social et al

Residual cardiovascular risk in coronary artery disease: from pathophysiology to established and novel therapies - Nature Reviews Cardiology In this Review, Galli and colleagues discuss the mechanisms and associated biomarkers of traditional and emerging factors responsible for the residual risk of recurrent adverse cardiovascular events i...

New therapeutic approaches, such as low-dose colchicine, PCSK9 inhibitors, antithrombotic therapies, GLP1 receptor agonists and SGLT2 inhibitors, offer new therapeutic avenues for reducing residual risk #CVD #heartdisease www.nature.com/articles/s41...

Development of a novel humanized gut-brain axis model as a tool toward personalized nutrition - Communications Biology Proof-of-concept of a humanised gut-brain axis ex vivo model with physiological coupling of intestinal and blood-brain barrier for mechanistical assessment of butyrate- or fiber-rich diets on the sero...

An ex vivo approaching for interrogating the gut brain axis and blood brain barrier function www.nature.com/articles/s42...

Microbiota utilization of intestinal amino acids modulates cancer progression and anticancer immunity Qiao et al. identify gut microbes and amino acid-metabolizing genes that influence tumor burden. A Bacteroides asparaginase, bo-ansB, modulates host tumor responses to dietary asparagine (Asn) by depl...

#NatMicroPicks

bacterial amino acid metabolism affects cancer progression 🦠🦀🐁

Bacteroides asparaginase lowers intestinal asparagine levels and drives colorectal tumor progression

#MicroSky

www.cell.com/cell-host-mi...

Associations between preservative food additives and type 2 diabetes incidence in the NutriNet-Santé prospective cohort - Nature Communications Exposure to twelve widely used preservative food additives are associated with a higher incidence of type 2 diabetes in the French NutriNet-Santé cohort of 108,723 adults, supporting recommendations to favour fresh and minimally processed foods

A study published in Nature Communications reveals that exposure to certain food preservatives, including potassium sorbate and sodium nitrite, correlates with a higher risk of developing type 2 diabetes. 🧪

Glucagon-like peptide-1 medicines and cancer - Nature Cancer Yabut and Drucker discuss clinical and preclinical evidence about the potential roles of GLP-1 medicines on cancer incidence, development and therapy and speculate about their mechanism on cancer cell...

Beyond #weightloss How might GLP-1 medicines modify rates of #obesity associated #cancer and response to treatment? www.nature.com/articles/s43...

Nature Health launches today! In our inaugural editorial, we outline our vision of 'health beyond medicine' and aim to publish research, reviews and opinion that bridges the 'implementation gap' between health research with policy and practice.
www.nature.com/articles/s44...

Human MASLD is a diurnal disease driven by multisystem insulin resistance and reduced insulin availability at night By studying metabolism across day and night in human participants, Marjot et al. show that MASLD is a nighttime disease driven by poor insulin action and low insulin levels. These daily patterns persist after weight loss, suggesting that nighttime metabolic dysfunction is a key driver of liver fat accumulation.

Online now: Human MASLD is a diurnal disease driven by multisystem insulin resistance and reduced insulin availability at night

Mitochondrial transfer from immune to tumor cells enables lymph node metastasis How cancer cells subvert immunity to colonize the lymph node remains unclear. Terasaki et al. uncover that lymph node metastasis may be driven by an immune-to-cancer mitochondria transfer axis that impairs immune function and augments cancer immune evasion programs through type I interferon signaling.

Online now: Mitochondrial transfer from immune to tumor cells enables lymph node metastasis

Fat sensory cues in early life program central response to food and obesity - Nature Metabolism Non-nutritive sensory components of high-fat diet, such as bacon flavour, are sufficient to impair metabolic health in offspring in mice.

RESEARCH | L Casanueva Reimon, SM Steculorum et al. (CECAD)

Non-nutritive sensory components of high-fat diet, such as bacon flavor, are sufficient to impair metabolic health in mice 🧪

Global glucagon-like peptide-2 receptor activation linked to increased obesity risk in the UK Biobank The glucagon-like peptide-2 receptor (GLP-2R) is recognized as a potential target for the treatment of obesity and type 2 diabetes (T2D). Yet, the impact and mechanism of GLP-2R activation on these me...

Variation in the GLP2R and the risk of chronic metabolic disorders @uk_biobank #genetics www.metabolismjournal.com/article/S002...

A minimally invasive dried blood spot biomarker test for the detection of Alzheimer’s disease pathology - Nature Medicine This multicenter study demonstrates use of dried and capillary blood as a minimally invasive, scalable approach for Alzheimer’s biomarker testing in research, with potential as a widely scalable population-based research approach, especially in resource-limited settings.

A study published in Nature Medicine demonstrates use of dried and capillary blood as a minimally invasive, scalable approach for Alzheimer’s biomarker testing in research, with potential as a widely scalable population-based research approach, especially in resource-limited settings. 🧪

It turns out that high-intensity interval training whether once or 3x weekly over 16 weeks reduces fat mass in adults with overweight and central #obesity #exercise www.nature.com/articles/s41...

Gut molecule shows remarkable anti-diabetes power An international group of scientists led by Professor Marc-Emmanuel Dumas at Imperial College London & CNRS, along with Prof. Patrice Cani (Imperial & University of Louvain, UCLouvain), Dr. Dominique Gauguier (Imperial & INSERM, Paris) and Prof. Peter Liu (University of Ottawa Heart Institute), has identified an unexpected natural compound that helps counter insulin resistance and type 2 diabetes. The compound, trimethylamine (TMA), is a metabolite created by gut microbes from dietary choline. According to a study in Nature Metabolism, TMA can interrupt a key immune pathway and contribute to healthier blood sugar levels.

Gut molecule shows remarkable anti-diabetes power

An international group of scientists led by Professor Marc-Emmanuel Dumas at Imperial College London & CNRS, along with Prof. Patrice Cani (Imperial & University of Louvain, UCLouvain), Dr. Dominique Gauguier (Imperial & INSERM, Paris) and Prof.…

#NewResearch

Gut microbes can produce ethanol and contribute to auto-brewery syndrome. FMT can potentially treat individuals with this syndrome and improve symptoms.

#microsky

www.nature.com/articles/s41...

Novel myo-inositol to butyrate fermentation pathway in the prevalent human gut species Dysosmobacter welbionis, a bacterium associated with improved metabolic and liver health Background Dysosmobacter welbionis is a recently discovered butyrate producer whose presence in stool correlates with improved metabolic health. Whether its abundance is reduced in individuals with me...

Congratulations to @microbesity.bsky.social on the publication of his new study on Dysosmobacter welbionis, and thanks to Patrice for letting me play a small part in it.

Nice start to the new year. :)
#microbiomesky

Thank you Lesley for your help and collaboration ! #ingutwetrust @bugsinyourguts.bsky.social

Microbiote et nutrition pour déjouer les mécanismes du diabète de type 2 Le TMA, produit par les bactéries intestinales à partir de la choline alimentaire, peut améliorer le contrôle de la glycémie. Une piste prometteuse contre le diabète de type 2.

Patrice Cani (WEL Research Institute – UCLouvain) et ses collaborateurs internationaux ont identifié un composé, le TMA, produit par les bactéries intestinales à partir de la choline présente dans certains aliments, capable d’améliorer le contrôle de la glycémie.
welri.org/cms/c_205381...