Scheiffele Lab

Molecular programs specifying properties and plasticity of parvalbumin interneuron innervation Parvalbumin-positive (PV) interneurons, a class of fast-spiking GABAergic interneurons, govern gain-control and the timing of neuronal signal propagat…

@scheiffelelab.bsky.social and I discussed the unique properties of synapses onto parvalbumin interneurons, the current knowledge & future aspects of the molecular mechanisms regulating these synaptic inputs: www.sciencedirect.com/science/arti...

Postdoc position: Synaptic specificity in cortical and thalamocortical circuits - VIB Overview The VIB-KU Leuven Center for Brain & Disease Research is part of the VIB Life Sciences Institute and is embedded within the KU Leuven, which ranks among the world’s top 50 universities. At ou...

Great Lab and a great project!

How Canadians Are Directing Their Ire at the U.S. Over Trump’s Tariffs Canadians are shunning American products and abandoning trips to the United States to protest the economic punishment President Trump has threatened to impose with tariffs.

Same here -

Transcriptomic neuron types vary topographically in function and morphology - Nature Transcriptomic profiling of neurons from the zebrafish optic tectum identified more than 60 cell types; functional imaging revealed that response tuning, morphology and connectivity of specific cell t...

Interesting integration of transcriptomic and imaging data from zebrafish optic tectum cells!

Science must step away from nationally managed infrastructure Scientific data and independence are at risk. We need to work with community-driven services and university libraries to create new multi-country organizations that are resilient to political…

Important article on the urgent question how to upkeep key information platforms for science

Novel environment exposure drives temporally defined and region-specific chromatin accessibility and gene expression changes in the hippocampus Curiosity-driven interactions with novel cues in our environment represent a common behavioral trait across the animal kingdom. Exposure to a novel environment (NE) reshapes the brain by promoting str...

Super-interesting new preprint from the Greenberg lab on a systematic analysis of plasticity-associated gene regulation!

Group Leader - Molecular Mechanisms of Environmental Adaptation We are seeking to recruit a highly motivated scientist to establish and lead an independent research laboratory at the EMBL Epigenetics and Neurobiology Unit in Rome. EMBL provides a unique environmen...

Exciting job opportunity in Europe!

Congratulations!!!

Nuclear Speckle Dynamics are Controlled by Polyphosphate Inhibition of CLK Proteins https://www.biorxiv.org/content/10.1101/2025.01.15.633116v1

Synaptic signatures and disease vulnerabilities of layer 5 pyramidal neurons - PubMed Cortical layer 5 (L5) intratelencephalic (IT) and pyramidal tract (PT) neurons are embedded in distinct information processing pathways. Their morphology, connectivity, electrophysiological properties...

Beautiful example of spatial proteomic dissection
of synapse diversity from De Wit Lab!

If you have been affected by the fires in LA, or are concerned about your ability to keep precious Drosophila strains going during the latest funding crisis, we will host your strains as a backup. Please email me.

Please amplify. If you are also able to host fly strains, add your name as well.

A great read!

pubmed.ncbi.nlm.nih.gov/39121543/

Associate or Senior Editor, Nature Neuroscience Job Title: Associate or Senior Editor, Nature Neuroscience Location: New York, Jersey City, Philadelphia, Washington D.C., Berlin or Shanghai Application Deadline: January 6, 2025 About Springer Natur...

Nature Neuroscience is hiring a computational/systems/cognitive editor! Come join our team! Happy to answer any questions.

springernature.wd3.myworkdayjobs.com/SpringerNatu...

Nothing is better than working with amazing talented people! Congrats Zeynep - so well deserved!

snoRNA-facilitated protein secretion revealed by transcriptome-wide snoRNA target identification Transcriptome-wide mapping of snoRNA targets reveals mRNA-snoRNA-7SL RNA ternary interactions, which facilitate nascent protein translocation to the ER and subsequent secretion.

…and another cool approach to uncover RNA-RNA interactions !
www.cell.com/cell/fulltex...

Inhibition of RNA splicing triggers CHMP7 nuclear entry, impacting TDP-43 function and leading to the onset of ALS cellular phenotypes Al-Azzam et al. reveal that SmD1, a member of the SMN complex, regulates CHMP7 translocation. Reduced SmD1 expression in sporadic ALS leads to CHMP7 nuclear translocation, while overexpression prevent...

Cool method!
www.cell.com/neuron/fullt...

The lives of cells, recorded - Nature Reviews Genetics Recent advances in genome engineering are enabling the recording of cellular histories into genomes, with single-cell and spatial omics technologies enabling their reconstruction into cellular lineage...

"The lives of cells, recorded"--our new review on genomic recording systems and how they can reveal the dynamics of multicellular development. A pleasure to work on this with amazing colleagues from the Allen Discovery Center for Cell Lineage Tracing.
www.nature.com/articles/s41...

EMBL Jobs We offer a wide range of challenging scientific and non-scientific positions at all of our European locations and encourage applications from international candidates at all career levels.

Want a job in an exciting, science-driven environment? Genome Biology Unit Group leader call at EMBL Heidelberg:
www.embl.org/jobs/positio...

Looking forward to AXON2025 - mark your calendars

Nonsynaptic encoding of behavior by neuropeptides A basic tenet of neuroscience is that animal behavior is generated by neural circuits that operate through synaptic transmission. On top of this synap…

Interesting read!

www.sciencedirect.com/science/arti...

Quantitative Comparison of Monomeric StayGold Variants Using Protein Nanocages in Living Cells To standardize comparison of fluorescent proteins and independently determine which monomeric StayGold variant is best for live microscopy, we analyzed fluorescent protein tagged I3-01 peptides that s...

Gold nugget?
www.biorxiv.org/content/10.1...

Biozentrum PhD Fellowships Program The Biozentrum encourages talented, ambitious and highly motivated young scientists from all over the world to apply for the prestigious and sought after fellowships offered by the Biozentrum Basel In...

Apply for our PhD program - great rotation system and great labs!
www.biozentrum.unibas.ch/phd/internat...

onlinelibrary.wiley.com/doi/10.1111/...