Spring is arriving in Boston and Jody Mou linkedin.com/in/jody-mou has some fresh new data to share!
Wednesday, March 11th 2026, 7pm EDT in Room 6055, Longwood Center @danafarber.bsky.social
"Computational Design of a Rapid and Orthogonal Self-Labeling Protein Tag for Live-Cell Imaging"
bpdmc.org
I had a great time nerding out about protein design with @nickpolizzi.bsky.social, and an enormous thanks to @biotechtv.bsky.social and @massbio.bsky.social for hosting us!
www.biotechtv.com/post/chris-b...
Yep, always fun to talk about proteins, especially designing them :) Thanks for having us @biotechtv.bsky.social!
I’m looking to hire a research technician for my lab at Harvard & DFCI, who would primarily work in the wet lab expressing and characterizing designed proteins, starting this summer. A great role for a recent college grad looking for an immersive research experience before grad school.
The research tech job posting is now live at careers.dana-farber.org/job/554/rese...
We've got Jeff Gray (graylab.jhu.edu) coming to present this month!!
Wednesday, February 25th 2026, starting at 7pm EST in Room 181, Building 68, @MIT
"Antibody language models vs. biology; protein docking denoising diffusion models vs. physics"
bpdmc.org
New Title Alert: LASErMPNN- is an all-atom ligand-conditioned protein sequence design and sidechain packing model that accounts for the presence of small molecules, including hydrogens.
Learn more here: buff.ly/cZcOmpC
#SBGridSoftware #SBGrid #StructuralBiology
Would ideally be a 2 yr commitment. I’ll update this thread with an official link to submit an application (coming soon), but in the meantime please feel free to email me with a CV and cover letter!
The tech would focus on protein-ligand binding, getting experience with biophysical methods such as SPR, ITC, fluorescence spectroscopy, NMR, X-ray crystallography, etc. Would also get experience with computational protein-design tools (though the role is primarily focused on experiments).
I’m looking to hire a research technician for my lab at Harvard & DFCI, who would primarily work in the wet lab expressing and characterizing designed proteins, starting this summer. A great role for a recent college grad looking for an immersive research experience before grad school.
Principles of in situ protein sequencing: expansion microscopy-adapted Edman degradation and amino acid recognition https://www.biorxiv.org/content/10.64898/2026.01.29.702630v1
The Cancer Signaling & Microenvironment Program at Fox Chase Cancer Center is looking for tenure track faculty (assist./assoc./full) in computational & experimental protein design. CV & 3-page research statement by Feb 15.
More info here:
www.linkedin.com/feed/update/...
Questions: DM/Email me.
Exciting stuff, Gabriele. Congrats!
Happy New Year! We've got an exciting seminar to kick off 2026
Wednesday, January 21st at 7pm EST
Room 181, Building 68 @mit.edu
speaker: Erik Swanson and Mike Nichols
"mBER: Controllable de novo antibody design with million-scale experimental screening"
bpdmc.org
Large scale prospective evaluation of co-folding across 557 Mac1-ligand complexes and three virtual screens https://www.biorxiv.org/content/10.64898/2025.12.25.696505v1
As someone trained in physics, this project really helped me learn the nuances of denoising diffusion models. The “time” variable acts as an alchemical transformation—e.g. RFDiffusion transforms between protein structure and an ideal gas.
Read the paper here!
www.biorxiv.org/content/10.1...
If you couldn't make it for @yehlincho.bsky.social's rockstar seminar last night, have no fear because you can check out the recording 👇
youtu.be/yCOlC_yj4kc
quick reminder to join us tonight for our final meeting of 2025 - it's going to be a great seminar by @yehlincho.bsky.social that you won't want to miss!
Announcement for the 6th Protein Engineering Canada Conference, to be held June 22nd-24th in Ottawa, Canada. The image shows a protein structure in front of a picture of Parliament Hill and Chateau Laurier in Ottawa.
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Save the date!
The 6th Protein Engineering Canada Conference will be held on June 22-24 in Ottawa, Canada.
Abstract submission and registration are open!
More information here: event.fourwaves.com/pec2026/pages
New preprint! Entropy drives molecular recognition, yet most structure-based drug design ignores it because it is difficult to measure. X-ray crystallography captures ensembles, not single structures. Can we extract thermodynamically meaningful entropy from them?
www.biorxiv.org/content/10.1...
Don't fret if you weren't in the room this week when @ginaelnesr.bsky.social gave her stellar seminar because you can check out the recording 👇
youtu.be/I-utRMS84E8
Congrats, Gabe! Interesting re: arg. Mutating surface lys —> arg also is known to help w crystallization. Wonder if related 🤔
Congrats, Chris!
@benf549.bsky.social made a nice little google colab notebook for running LASErMPNN for protein sequence design conditioned on ligands. Check it out! Feedback welcome. colab.research.google.com/github/poliz...
We can't wait until Wednesday, November 19th 2025 to arrive because we have @ginaelnesr.bsky.social from @possuhuanglab.bsky.social speaking at 7pm EST in Room 6055, Longwood Center, @danafarber.bsky.social
"Learning millisecond protein dynamics from what is missing in NMR spectra"
bpdmc.org
Heartbreaking. So sorry to hear this, Willow
Last week to apply!
thanks everyone who packed the house tonight at @mit.edu for an incredible seminar by @grocklin.bsky.social!
quick reminder to come see @grocklin.bsky.social tonight at @mit.edu!
