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Sachin Pundhir

@pundhir

Senior Scientist - Computational biology @UCPH_BRIC, @Rigshospitalet Interest: regulatory genomics in stem cell differentiation and cancer using #DataScience #ML https://scholar.google.com/citations?hl=en&user=KNHvdX8AAAAJ&view_op=list_works&sortby=pubda

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Latest posts by Sachin Pundhir @pundhir

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Are you looking to establish yourself as a scientific group leader? Biotech Research & Innovation Centre (BRIC), University of Copenhagen is recruiting 1-2 junior group leaders to join our research centre in the heart of Copenhagen.
See more at www.bric.ku.dk

Please repost and get in touch

28.12.2025 13:59 ๐Ÿ‘ 12 ๐Ÿ” 12 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 1
Preview
A conserved H3K14ub-driven H3K9me3 for chromatin compartmentalization - Nature G2E3-catalysed H3K14 mono-ubiquitination is crucial for SUV39H compartmentalization and H3K9 trimethylation in pericentromeric heterochromatin, which is essential for proper euchromatin organization a...

www.nature.com/articles/s41...

16.10.2025 15:54 ๐Ÿ‘ 3 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
PADIT-seq reveals multiple overlapping binding sites determined transcription factor occupancy
PADIT-seq reveals multiple overlapping binding sites determined transcription factor occupancy YouTube video by Shubham Khetan

he partnered with The Happy Slate to create a 3-minute animation explaining this work! please check it out :)

youtu.be/KFPZ9Rhjs4Y

03.09.2025 15:34 ๐Ÿ‘ 5 ๐Ÿ” 1 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0

This preprint is now a published peer-reviewed paper! Thanks to all the co-authors involved, to the funders and to @reviewcommons.org and @embopress.org @emboreports.org for a smooth editorial process! Excited to see this in press! www.embopress.org/doi/full/10....

@imperiallifesci.bsky.social

20.08.2025 13:23 ๐Ÿ‘ 43 ๐Ÿ” 21 ๐Ÿ’ฌ 4 ๐Ÿ“Œ 2
H3K4me3 amplifies transcription at intergenic active regulatory elements A biweekly scientific journal publishing high-quality research in molecular biology and genetics, cancer biology, biochemistry, and related fields

New paper on the role of H3K4me3 at enhancers! We (led by Haoming Yu) used dCas9 epigenome editing to add H3K4me3 to intergenic enhancers. This was (1) sufficient to turn up transcription at open, active regions and (2) has no effect on target gene transcription. genesdev.cshlp.org/content/earl...

20.08.2025 01:28 ๐Ÿ‘ 84 ๐Ÿ” 33 ๐Ÿ’ฌ 3 ๐Ÿ“Œ 1