CNPY4 joins the growing list of lipid-binding regulators keeping cellular membranes balanced — exciting times for membrane & lipid biology!
#lipidbiology #cellbiology #biorxiv #sphingolipids
Why it matters 🧠
🧩 Reveals a new lipid-binding regulator in cells
⚙️ Links SAPLIP family proteins to membrane lipid regulation
🧪 Opens questions: how is CNPY4 controlled? disease relevance?
Our work uncovers a new molecular player: CNPY4.
CNPY4, a saposin-like protein, directly binds sphingolipids
Loss or perturbation of CNPY4 disrupts lipid distribution + abundance → reshaping membrane architecture & possibly signaling pathways. This is a new layer of control in lipid homeostasis.
Happy to share our new preprint in collaboration with Natalia Jura's lab! 🧬
CNPY4 is a lipid-binding regulator of sphingolipid homeostasis
👉 biorxiv.org/content/10.1101/2025.10.13.682155v1
Sphingolipids shape membranes & signaling — but how their balance is maintained is still unclear.
🔔SAVE THE DATE!🔔
Leanne Jones and I are super excited to announce the 3rd Intestinal Stem Cell conference is taking place next November in Mexico. Registration now open, ECR grants available and our Keynote, Hans Clevers, is confirmed.
More info➡️ bit.ly/474De1E
YOUR PHONE EXISTS because the government invested in "useless" basic research decades ago!
It's the same with medical research - today's basic science leads to tomorrow's life-saving treatments.
Visit FundResearch.org to tell Congress to keep funding research
#SaveOurCures #PhoneForGood #FundNIH
🎉 INTRODUCING #SaveOurCures🎉
Federal biomedical research represents less than 1% of the federal budget but delivers life-saving treatments for millions of American families.
93% of cancer treatments started with American government-funded research.
🧵:
1/8
Trump Is Shutting Down the War On Cancer www.nytimes.com/2025/09/14/m...
We're very excited to launch a search for a founding director of our new reproductive sciences program at Cedars-Sinai! careers.cshs.org/job/los-ange...
🎖️Congratulations to Carole Ober, PhD, winner of the ASHG 2025 Mentorship Award! Learn more about the award and Dr. Ober's work: https://www.ashg.org/membership/awards/2025-awardees/ #ASHG #HumanGenetic
Final version @science.org "Recent evolution of the developing human intestine affects metabolic and barrier functions". Evolutionary preparation for microbiota, diet, and pathogen exposure is fascinating! Thank you @erc.europa.eu for supporting our vision!
www.science.org/doi/10.1126/...
UCLA professor Bill Lowry: My current basic-research grant from the National Institutes of Health, which is a continuation of the work that led to this discovery on alopecia, was suspended last week. I don’t know what interesting discoveries won’t be made the longer this thing stays suspended. 🧪
The findings, if confirmed in humans, could one day lead to treatments that enable rapid, scarless recovery from skin wounds on other parts of the body."
www.cedars-sinai.org/newsroom/pre...
"Your mouth is a magician. Bite the inside of your cheek, and the wound may vanish without a trace in a couple of days. A new study has discovered one secret of this disappearing act.
Excited to share our new paper by Jessi Cook in collaboration with Michelle Griffin from Mike Longaker's group at Stanford.
www.science.org/stoken/autho...
As nicely described by our communications team:
Join us in Crete in the fall to discuss stem cells! The early bird deadline has been extended to July 15th. This date will be the final deadline for abstracts being considered for short talk selection. www.aegeanconferences.org/src/App/spea...
Looking forward to seeing you there!
Activation of angiotoxin receptor–like signaling and suppression of focal adhesion kinase allow for regenerative healing in the oral mucosa
www.science.org/doi/10.1126/...
@ophirklein.bsky.social
Here Is All the Science at Risk in Trump’s Clash With Harvard www.nytimes.com/interactive/...
Talked to @KateZernike at @nytimes about my journey and the current moment for scientists in the U.S.
“Ardem Patapoutian’s story is not just the American dream, it is the dream of American science.”
Read the article here. No subscription required:
www.nytimes.com/2025/06/03/u...
Sorry to read this and glad you are on the mend!
Europe’s choice is clear.
To put science at the heart of its economy.
To become the home of scientific freedom and collaboration.
And to welcome talent from all over the world.
I’m glad to present the first elements of our Choose Europe Initiative.
→ europa.eu/!TTbWbJ
Urge Congress to Reject the President's Budget Proposal to Cut NIH, NSF www.congressweb.com/ASHG/32?fram...
This is something I keep asking myself: www.nytimes.com/2025/04/11/o...
It was an honor to speak at the Shanthi Sitaraman Symposium at Emory yesterday, and to hear about Shanthi from her colleagues, friends and family. She was a remarkable physician, scientist and teacher.
