Darren Incorvaia

FDA approves leucovorin for ultrarare cerebral folate deficiency subset without clinical trial About five months after U.S. Department of Health and Human Services Secretary Robert F. Kennedy Jr. | About five months after U.S. Health Secretary Robert F. Kennedy Jr. touted leucovorin as “an exci...

After rejecting multiple rare disease therapies that had clinical data, the FDA has approved leucovorin for a super rare kinda-related-to-autism disorder with...no clinical trial whatsoever. In related news, up is now down and down is up

FDA’s Vinay Prasad to depart agency at the end of April Editor's Note: This is a developing story. Please check back for updates. | After a tumultuous tenure marked by recent clashes with the biopharma industry, Vinay Prasad, M.D., will be departing his po...

Yup he’s gone apparently for good this time www.fiercebiotech.com/biotech/fdas...

Remember when Rep. Greg Gianforte, now the GOP governor of the state, body slammed a reporter into a table?

We probably need to shut down the Montana Republican Party entirely until we can figure out where all this violent rage is coming from.

Meet three scientists who said no to Epstein The warning signs included a web search, a mother’s doubts, and inklings of a “sexist attitude”

Many of the scientists Jeffrey Epstein courted were already well-established and well-funded. So why didn’t they all just say no? Science talked with three who did just that.

Here’s how Epstein approached them, and why they refused to have anything to do with him. ⬇️ https://scim.ag/40qbXnv

BLM Announces Plan to Fell Oregon's Last Great Forests One billion board feet per year... 30 days to make your voice heard.

You only have a short time to comment. They are trying to destroy our forests to enrich a few logging company executives and the politicians they’ve paid off.
Leave your comment here:

eplanning.blm.gov/Participate-...

morethanjustparks.substack.com/p/blm-announ...

Ok more than sometimes hostile to but I'm trying to be diplomatic here

Lilly debuts Nvidia supercomputer with fanfare and focus on escaping traditional pharma lifecycle On some level, Eli Lilly’s partnership with computing giant Nvidia feels inevitable. | On some level, Eli Lilly’s partnership with computing giant Nvidia feels inevitable. The first pharma to reach a ...

I am generally skeptical of (and sometimes outright hostile to) all the AI hype, so it was refreshing to hear Eli Lilly’s chief AI officer express reverence for biology's complexity and tell me that AI can’t replace human curiosity 🧪 full story here:

And the full list of finalists is here: nealawards.siia.net/2026-neal-aw...

Panacea potential: How Nobel-winning regulatory T cells could become a 'universal drug' While presenting this year’s Nobel Prize in Physiology or Medicine to three immunologists who

Very pleased that my story about turning award-winning cells into new medicines is a finalist for a Neal Award 💊 check it out!

Longevity guru Peter Attia exits CBS News after Epstein emails surface Communications newly released by the Justice Department reveal chummy communications between the two men.

Breaking news: Peter Attia, a physician and prominent longevity influencer, is stepping down from his role as a CBS News contributor after the Justice Department released hundreds of previously undisclosed emails between him and Jeffrey Epstein.

Little Caesar’s hot and ready 4ever

Ionis scraps early candidate for Alzheimer’s in people with Down syndrome Ionis Pharmaceuticals has pulled the plug on an early investigational treatment for Alzheimer’s disease in people with Down syndrome, marking another setback for a group of patients who are both at | ...

Ionis has pulled the plug on an early investigational treatment for Alzheimer’s in people with Down syndrome, a tough break for a group of patients who are both at higher risk for the condition and not served by current therapies 🧪💊 my story:

Note: Appeals to “precedent” are confusing here, since several non-politicians have lied in honor at the Capitol — including Rev. Billy Graham.

The list below is from the House’s own website on the topic: history.house.gov/Institution/...

4 journalists detained in Cameroon reporting on Trump’s deportations Lawyers say Trump is sending migrants to Cameroon who originated elsewhere. AP freelancers, among others, were detained while reporting on the deportees.

Four journalists, including three working for the Associated Press, were detained in Cameroon while reporting from a facility where migrants deported by the Trump administration are held, according to two lawyers.

Pepper-wrongi

This Weeks Editorial Cartoon: Pepper-wrongi

tweet from @cliftonhowze on twitter Last night at the #DataCenters meeting in Claremore, Darren Blanchard, who has attended most of these meetings around NE Oklahoma & has some pretty impressive FOIA/ORA skills, was arrested after going over his 3 min. allotted speaking time. First arrest I've seen at one of these.

in america, if you go over your 3 minute allotment to speak, men with guns come to take you away.

After leaving WHO, Trump officials propose more expensive replacement to duplicate it HHS proposes spending $2 billion a year to re-create systems the U.S. accessed through the WHO at a fraction of the cost, according to officials briefed on the matter.

Step 1: Withdraw from WHO
Step 2: Spend a much larger amount to recreate WHO benefits
Step 3: ????????
Step 4: Profit

www.washingtonpost.com/health/2026/...

Blood from pediatricians yields potential new medicines for respiratory viruses Constant exposure to diverse diseases is an occupational hazard for all healthcare workers, especially those who work with children. | Constant exposure to diverse diseases is an occupational hazard f...

Kids are notoriously germy, so pediatricians come face to face with a slew of diverse diseases every single day--call it an occupational hazard. It turns out all that exposure makes the docs pump out some powerful antibodies, which might make good new medicines for pesky viruses 🧪💊 my story:

Moderna Reversal

This is no way to run a regulatory agency:

Using our bee-tracking drone, we discovered that honey bees 🐝 have highly precise and individual routes. Now published at @currentbiology.bsky.social : doi.org/10.1016/j.cu...

FDA rejects Disc’s rare disease drug despite commissioner’s voucher The FDA has rejecte | The FDA has rejected a rare blood disease candidate from Disc Medicine, a compound that been granted expedited review through a newly launched priority voucher program.

FDA has been on a rejection spree this week, turning down treatments for two rare diseases where patients currently have very limited options

To me the chatbots pose zero interesting questions about the ‘nature of selfhood’ but dozens about the nature of manipulation. Here the Claude team pretends they are programming the robot for ethical responses but they land on one that is false and disingenuous.

What beauties! 🐝

A bumblebee looking straight at the camera, standing on a leaf with bright light coming from behind. The hair around the head is yellow and black.

In this picture, the bumblebee has turned to the side, giving us a better full view of the largest pair of eyes.

I saw my first bumblebee of the year on the farm today. Even with a relatively warm day, they were understandably sluggish. There are a few small flowers about, so I hope they can find something to eat.

Those eyes. That hair. Iconic.
#oregon #bees #pnw

‘The only thing that saves us is data’: Allogeneic CAR-T biotechs fight for relevance as industry moves on Ever since 6-year-old Emily Whitehead became the first patient to receive CAR-T cell therapy in 2012, when T cells were removed from her body and reprogrammed to attack her leukemia before being re | ...

Since 2012, when the first leukemia patient was treated with engineered versions of her own T cells, scientists have tried to make the therapy more accessible by using donor cells instead. So far, they have failed. Read my deep dive and decide for yourself if 2026 is the year they turn it around!

Moderna hit with FDA refusal-to-file letter for mRNA flu shot, issues sharp rebuke of agency's rationale During the first year of the Trump administration, signs of an anti-mRNA slant within the FDA and HHS became more and more evident. | The FDA specifically took issue with the trial's control arm, whic...

For people who don't follow the FDA closely: this is insane. Like my jaw hit the floor when I saw this. The FDA is flat out refusing to even consider Moderna's application for a new flu vaccine? The federal health apparatus is fully compromised by anti-vax conspiracy. THIS IS NUTS! BAD

FDA rejects Regenxbio's gene therapy in Hunter syndrome, leaving CEO 'concerned' After facing a delayed decision deadline and a clinical hold, Regenxbio’s Hunter syndrome gene therapy has been rejected by the FDA. | After facing a delayed decision deadline and a clinical hold, Reg...

Devastating news for patients and their families. This gene therapy has been on a wild ride--a delay, a clinical hold, and now rejection. Also troubling that the FDA is rejecting the use of a biomarker that is widely accepted by the research community 💊🧪 my story:

Absolutely devastating

New genera, species and occurrences of Goniasteridae (Valvatida, Asteroidea) from New Caledonia | Megataxa

CRAZY diversity of sea stars fr NEW CALEDONIA! I describe 28 NEW SPECIES,3 NEW GENERA! #echinoday #goniasteridae #openaccess. My thanks to colleagues at the @MNHN.fr in Paris! for my many visits in order to complete this research! Will share some of my favorites herein! mapress.com/mt/article/v...