Karen Schindler

A persistent intracellular bridge and cell cycle misregulation enable polar body cell divisions and tumor formation in Mos-deficient eggs Mammalian female meiosis is uniquely regulated to produce a developmentally competent egg capable of supporting embryogenesis. During meiosis I, homologous chromosomes segregate, with half extruded in...

Check out our new manuscript on biorxiv on the role of MOS in mammalian oocyte meiosis: www.biorxiv.org/cgi/content/...
With @schindlerlab.bsky.social @giselacairobaza.bsky.social @muhammad-haseeb.bsky.social

My department at Dartmouth Medical School is hiring a tenure-track Assistant Professor. We are looking broadly for a biochemist or cell biologist. Please share this add! apply.interfolio.com/171438
@dartmouthbcb.bsky.social @futurepislack.bsky.social

Dartmouth is hiring! Come be my colleague. Biochemistry and Cell Biology is accepting applications for a tenure-track Assistant Professor position. Join us in New Hampshire for great science, nice people, and beautiful scenery ⛰️ apply.interfolio.com/171438

Happy Sunday everyone! Have a look at the latest #papers on #oocyte and #embryo cell biology! This week we have a collection of useful #protocols to monitor chromatin and transcription in our favourite cells!

biomed.news/bims-cebooc/...

Thanks @biomednews.bsky.social for preselecting!
#cebooc

Attention SSR Annual Meeting attendees:
Don't miss registration for the Lunch and Learn session with Dr. Kelly Diggs to sharpen up your mentoring skills!
#reprorocks #womeninstem

At FIR we love eggs and fertilization- worm or mouse!

Busy FIR days at the @mblscience.bsky.social. At the end of last week FIRbees learned how to collect and inject follicles and oocytes and experienced the beautiful diversity of marine reproductive biology strategies.

Last night the FIRbees at the @mblscience.bsky.social did a hands on activity to learn about how the Retinoic Acid wave controls spermatogenesis and how that impacts tubule staging. Such a cool and powerful activity from Beth Snyder- @rnaisthenewdna.bsky.social!

Section 2 of Frontiers in Reproduction @mblscience.bsky.social has started! FIRbees learned how to prep single cell suspensions from testes with Brian Hermann and sperm capacitation with @marianobuffone.bsky.social. Thanks to @10xGenomics and @Hamilton Thorne for tech support!

Damn it- now I'm crying again!! Right back you!

I'm up at the MBL to kick off Section 2 of Frontiers in Reproduction tonight. Missing Mother's Day with my kiddos, but my amazing husband did interviews with them to send me. This one had me in tears. He gets what we do and he's only 11.

@ceciblengini.bsky.social may have moved on from my lab, but we’re still hard at work to publish all her amazing findings. Here we find that Aurora A phosphorylates Hec1 at Serine 69 in mouse oocytes and this can help ensure chromosome alignment. Check it out!

Not the renewal renewal… there would be more excitement for that! Just a non-competitive renewal. But, given yesterday’s NIH news… none of that matters.

Thank you for your kind words! We have to celebrate all the wins these days!

Taking every bit I can get!

Finally some positive news for the lab this week. Non-competitive renewal NoA arrived (phew) and a paper accepted (yay!)

New step taken towards non-hormonal contraception A new study from Karolinska Institutet shows how a small antibody fragment can block fertilisation by targeting a key protein on the surface of the egg. This discovery brings a non-hormonal contracept...

New step taken towards non-hormonal contraception

news.ki.se/new-step-tak...

Intercellular bridges are essential for transposon repression and meiosis in the male germline - Nature Communications A conserved feature of metazoan meiosis is that it occurs in a syncytium. Here, the authors show that intercellular bridges that connect germ cells in a syncytium are critical for ensuring proper meio...

For my first science post here, I’m proud to advertise our latest work exploring why germ cell connectivity is really important for meiosis 🐁

Done with some awesome colleagues @florpratto.bsky.social

www.nature.com/articles/s41...

Amazing! So proud to live in NJ. Thank you @booker.senate.gov ! We have the best senators.

Thanks Senator @kim.senate.gov for the science round table at Rutgers. We discussed the importance of NIH funding for R&D, workforce training, & helping patients. Politicizing the NIH threatens our global competitiveness and quest for disease cures.

@schindlerlab.bsky.social
@matiset.bsky.social

I did something exciting today with my two amazing genetics dept colleagues @schindlerlab.bsky.social and @matiset.bsky.social. We joined a round table discussion on science, innovation and industry with NJ Senator Andy Kim @kim.senate.gov. We have some new strategies to #standupforscience2025! 💪🧪

Great pro-science rally today in Trenton at #standupforscience2025.

Close to 600 people for the Trenton Stand Up For Science rally. Great chants, NJ schools out in force, and scientists discovering their inner extrovert. Rush Holt led off, me at end.

Scene from Rutgers "Hands Off Our Research" Protest. Professor Monica Driscoll - National Academy of Sciences member - rallies our undergrads, grad students, postdocs, staff, faculty, and community. The resistance is growing!!! @ruaaup-aft.bsky.social @aaup.bsky.social #celegans

Thank you for amplifying. Let’s GO New Haven!

Calling all postdoctoral WinRS! There's 1 more week left to apply for the L'Oreal Women in Science Fellowship! Click on the link in our linktree to apply by Feb. 14th #reprorocks #womeninstem #loreal💪

I’m wondering the same. It was a required part for submission.

Thank you for doing this. It was the push I needed! And felt great.

Oh, I’m so sad to learn this. A huge loss.