1/6 Check out our new study in @currentbiology.bsky.social that examines how our brain accommodates for two opposing demands - efficient and yet accurate learning. 🧵👇
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1/6 Check out our new study in @currentbiology.bsky.social that examines how our brain accommodates for two opposing demands - efficient and yet accurate learning. 🧵👇
Congratulations Shai! Very proud to be a part of this project.
Super excited to share that the “sequel” to my PhD research at the Parnas lab has been published as a featured article in Communications Biology! 🧵👇
www.nature.com/articles/s42...
Excited to share our latest work - expressing the bacterial sodium channel in fly Kenyon cells surprisingly *decreases* their excitability, thanks partly to decreased endogenous sodium channels. This prevents learning and decreases odor-evoked calcium influx doi.org/10.1113/JP28...
Congrats, Eyal! A great way to start.
✨😀Congratulations to postdocs Eyal Rozenfeld and Francesco Limone on being named 2025 Leon Levy Scholars by The New York Academy of Sciences!
@sciencelemon92.bsky.social
@eyalrozenfeld.bsky.social
@moccalin.bsky.social
@liddelowsa.bsky.social
www.nyas.org/press-releas...
1/ Check out our Juila Manoim, Tal Camchy, @eyalrozenfeld.bsky.social, Hadas Lerner, Hao-Hsin Chang, Ran Darshan, and Ya-Hui Chou new study in @currentbiology.bsky.social. www.sciencedirect.com/science/arti...
I started my lab more then 4 years ago, and we have endured some very challenging times ever since.…I am very excited to share the first paper from my lab, published now in @naturemethods.bsky.social
www.nature.com/articles/s41...
Our story about flies on carousels is out in @currentbiology.bsky.social! After formally engaging the fantastic @clarahowcroft.bsky.social and integrating helpful reviewer feedback, we present a more concise story with detailed behavioural quantification and cooler videos! doi.org/10.1016/j.cu...
So happy to see this paper out! Congrats @victoriacorbit.bsky.social and @ahmarilab.bsky.social! Lots of fond memories from running these experiments. The similarity in the behavioral and striatal neural response time course produced by driving M2 inputs was really striking.
The locus coeruleus norepinephrine (LC-NE) system regulates arousal and awakening; however, it remains unclear whether the LC does this in a global or circuit specific manner. We hypothesized that sensory-evoked awakenings are predominantly regulated by specific LC-NE efferent pathways. Anatomical, physiological, and functional modularities of LC-NE pathways involving the mouse basal forebrain (BF) and pontine reticular nucleus (PRN) were tested. We found partial anatomical segregation between the LC->PRN and LC->BF circuits. Extracellular NE dynamics in BF and PRN exhibited distinct sound-evoked activation during sleep, including a fast sound-evoked NE peak specific to PRN. Causal optogenetic interrogation of LC efferent pathways, by retro-ChR2 activation or PdCO silencing of synapses in target regions, revealed a pivotal role for early LC->PRN activity in driving arousal and sound-evoked awakenings. Together, our results uncover a prominent role for early LC-NE PRN activity in connecting sensory and arousal pathways and establish LC heterogeneity in regulating arousal.
An early surge of norepinephrine along brainstem pathways drives sensory-evoked awakening
www.biorxiv.org/content/10.1...
Happy to see this great work (and some PdCO application) out in the wild.
Marlin Lab’s 1st Thesis Defense ✨
Hear the science @2:30pm EST
bit.ly/MarlinLab
Have the cheers @5:00 pm EST JLG✨
Columbia Biology student Beka Stecky will share her discoveries on “What the Nose, Knows” after learning an odor predicts a stressful experience.👃🏽🧬🧪
My thesis defense date is official! And yes I put my cat and Tac2 neurons on my poster 🥰
Antipsychotics is often used to suppress hyper-aggression. Does it really suppress aggression or just cause sedation? Antipsychotics targets dopamine receptors. Our new study revealed that dopamine modulates aggression based on animals' fighting experience.
www.nature.com/articles/s41...
Fly neuro people: has anyone tried the Ting lab’s scFLARE (or variants) for labelling active neurons in Drosophila? Thanks.
🚨Postdoc and Postbac positions available in my group at the NIEHS/NIH!
Interested in investigating the neural mechanisms for social behaviors across development in a supportive environment? Make sure to apply!
Job ads in🧵Feel free to DM/email w/ questions, please RT
We are hiring!
We are looking for two PhD students interested in the regulation of habit formation. Habits are useful to decrease cognitive load, but carry the risk of becoming stereotyped and hard to control - it’s hard to shake a bad habit. The fruit fly Drosophila also forms habits and we […]
New year new work from the lab! We explore whether aggression experience and observation lead to similar changes in future aggression strategy. (They do!) We perform 2-color imaging across the whole social behavior network across time and track changes www.biorxiv.org/content/10.1...
(1/6) Excited to introduce our first generation red acetylcholine sensors! #acetylcholine #GRAB #RedSensors
www.biorxiv.org/content/10.1...
🎄PinkyCaMP- our christmas gift to you! 🎁: We are excited to present PinkyCaMP, the first mScarlet based calcium sensor with:
✨exceptional, brightness
✨phototability
✨and optogenetic compatability.
Check out our new preprint:
www.biorxiv.org/content/10.1...
Apropos of never ending discussions about whether ANNs are "good" models of the nervous system, here is a slide I present to masters students showing a network that is found in motor control circuits *across phyla* (that's pretty ubiquitous!) I ask them to guess what it does...
Why not joining us?
Wanna switch on/off synaptic transmission but not the ideal vector for your🧠🧪🔬, we are happy to help!
Requested recently & available to you:
ChrimsonR(no soma targeting)+PdCO (Cre & non-Cre)
DoxOn/OFF PdCO-EGFP (TREtight)
-> docs.google.com/spreadsheets...
Probably soon @addgene.bsky.social too.
Sex or survival—what’s more important? Excited to share our
@Nature paper on how flies resolve this conflict.
We found a dopamine-based filter that reduces threat perception, helping flies focus on courtship when close to mating.
www.nature.com/articles/s41...
Hi everyone!
I am Daniela, a pre-clinical psychedelic researcher doing a PhD at the Paris Brain Institute under the supervision of Eric Burguière. I am working with the SAPAP3-KO mice and LSD.
I am a great advocate for open science, diversity and science communication!
Nice to meet you all 🥰
Neuroscience students asked us to teach a PRACTICAL course on experimental methods, and it is now on YouTube!
Please like and repost to help us get the word out!
www.youtube.com/playlist?lis...
Lecture 1: Signals and data acquisition
Focusing on hardware, digital/analog I/O, synchronization
🧵
I made the Insect Sensory Neuro starter pack - let me know in the comments if you'd like to be added! (and also I'm sure I missed tons of people - tag them in!)
go.bsky.app/JW7c5LN
Excited to have this paper out (rdcu.be/d0T3Y)! In it, we focused on how flies know what to attend to in a complex environment (like below)?
We uncovered neuronal pathways through which social states (like aggression 🥊) modulate visual processing in #Drosophila. #WomenInSTEM #neuroscience 🧪 1/
