For Pokémon’s 30th anniversary, Nature spoke to scientists from around the world about how their work has been shaped by playing Pokémon games, watching animated TV series and films and trading cards in school playgrounds. 🧪
Long-lived resident tissue macrophages govern intraocular pressure homeostasis by regulating extracellular matrix turnover, contributing to resistance-generating tissues that are dysfunctional in glaucoma @cp-immunity.bsky.social
www.cell.com/immunity/ful... @dukeeyecenter.bsky.social
C1q activates the mitochondrial enzyme SARM1, driving NAD⁺ cleavage into cADPR, which precipitates metabolic collapse and PANoptosis of homeostatic macrophages, amplifing autoimmune tissue inflammation @ImmunityCP @Stanford
www.cell.com/immunity/ful...
Fun to see this on the cover of Cytoskeleton!
Microtubule and actin filaments captured by @sareenfiaz in the Aiken Lab 🔬
#Cytoskeleton #CellBiology #Microscopy #LabLife
Ramphal, Waisman et al. @mainzuniversity.bsky.social reveal that NIK drives neuroantigen-specific T cell priming by regulating antigen presentation and IL-23 production, identifying NIK as a key orchestrator of #myeloid-driven CNS #autoimmunity. rupress.org/jem/article/...
#Neuroinflammation
Spatial transcriptomics (ST) should be conductive to anyone who has done microscopy in their lives, but it's not! Resolution vs coverage tradeoffs, static workflows, heavy data analysis still plague it...
IT'S TIME TO CHANGE THIS!!
INTRODUCING NaVis
www.biorxiv.org/content/10.6...
Do you know what every university’s library needs? A kids room (aka “family study room”) like this 👇
3 adults and 7 kids (!!!), and- believe it or not- but we actually worked for a few hours, while kids were having a blast creating pure chaos all around 😏
Thanks @towsonu.bsky.social!
#GLIA2025 Spotlight: Francesco Limone (NYU ITNS @sciencelemon92.bsky.social) studies how reactive astrocytes impact neuron survival using mouse astrocyte–human neuron co-cultures. Insights into neuron-astrocyte crosstalk may reveal targets to protect neurons in neurodegeneration!
High-dose nusinersen for spinal muscular atrophy: a phase 3 randomized trial www.nature.com/articles/s41...
“The question is whether we will act while AI governance frameworks are still forming or will normalize preventable deaths, discrimination, and erosion of public trust”. Every scientist should read this piece by @alondra.bsky.social arguing for an ELSI for AI. This work is essential.
Our Paper is out! We studied cortical microglia and regenerating oligodendrocyte (OL) interactions. In short: demyelination induces transiently reactive microglia and depletion of these reactive microglia increase recovering OL number onlinelibrary.wiley.com/doi/10.1002/...
Review @cp-trendsimmuno.bsky.social
Microglia in systemic neuroimmune communication: functions beyond phagocytosis
www.cell.com/trends/immun...
Thrilled to share our new paper on reactive microglial plasticity! Using long-term fate mapping and epigenetic profiling, we uncover the remarkable plasticity of reactive microglia across the lifespan and the enhancers and associated TFs that govern state transitions.
Parent and pediatrician here.
All vaccines are still available & recommended. Talk to your pediatrician for more info.
Know this: Even as our government shifts its recommendation language, I would never forgo the RSV, hepatitis A & B, or meningitis vaccines for my own kids.
Short sighted and vindictive- a self-inflicted wound.
www.theguardian.com/us-news/2025...
Out today! Taking the diagnostic challenges from clinic into the lab bench to learn from our rare disease patients
Thanks to David Yule and his team for partnering with us in this project
www.neurology.org/doi/10.1212/...
My quote of the day
Ignorance more frequently begets confidence than does knowledge: it is those who know little, and not those who know much, who so positively assert that this or that problem will never be solved by science.
Charles Darwin
Brown and Rhode Island are my home- where I met my husband and friends for life and became a scientist. So much that is good in my life comes from there. It doesn’t have to be this way.
Caspase-8 expression in CD8+ T cells promotes pathogen restriction in the brain during Toxoplasma gondii infection www.science.org/doi/10.1126/...
Spinal motor neurons in dazzling detail. ✨
Each green dot is a spinal motor neuron - crucial but rare cells making up just 1% of neurons in the spinal cord. In diseases like ALS, they are selectively damaged, making them of special interest to neuroscientists.
#neuroskyence #FluorescenceFriday
Super excited to share this new story led by @jedziabis.bsky.social where she defines a critical role for microglial innate immune signaling in PV cell and perineuronal net (PNN) development in hippocampus, and consequences for plasticity and behavior in adulthood www.biorxiv.org/content/10.6...
my five year old had RSV when he was six months old and when we brought him to the pediatrician they were like yeah go directly to the hospital we’re calling ahead
scariest few days of our lives
from the bottom of my heart: all these people can go to hell
We need better ways of capturing the reality of research funding - Colin’s thread shows one desperate situation where a thriving lab has been strangled, but won’t show up in counts of officially terminated projects
Confocal image of Pdgfra+ oligodendrocyte precursor cells in yellow near pdgfra-stained blood vessels. Olig2 marks the OPC nuceli in magenta, and dapi (blue) labels all nuclei
#fluorescencefriday OPCs hanging out near blood vessels in the brainstem
🟡 Pdgfra
🟣 Olig2
🔵 DAPI
Thrilled to share our new publication on the regulatory code of injury responsive enhancers in the CNS!
www.nature.com/articles/s41...
@ellorens.bsky.social
@ki.se
@natneuro.nature.com
I was featured on The Scientist as a part of their 'Postdoc Portraits' series where I spoke about my scientific career path and ongoing work on oligodendrocyte dysfunction in neurodegeneration. Check it out! www.the-scientist.com/postdoc-port...
Microglial CLEC7A restrains amyloid beta plaque pathology in a mouse model of Alzheimer's disease alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
@alzdemjournals.bsky.social
Macrophages mediate mesoscale brain mechanical homeostasis
advanced.onlinelibrary.wiley.com/doi/10.1002/...
Deciphering cell-type-and temporally specific matrisome expression signatures in human cortical development and neurodevelopmental disorders via scRNA-seq meta-analysis
www.nature.com/articles/s41...
Our work out in @devbiol.bsky.social, PDGFra is needed for 🧠 perivascular fibroblast development... ⬇️ perivascular fibroblast = ⬇️ perivascular macrophage...cross-talk? 👀
Led by Hannah Jones @hejcell.bsky.social w/ Kelsey Abrams, Sophia Kim, excited for more projects w/ @fantauzzolab.bsky.social!
