Edward Fon

N-terminal acetylation reduces α-synuclein pathology in models of Parkinson’s disease The α-synuclein protein, encoded by SNCA gene, is a major constituent of pathological intracellular inclusions such as Lewy bodies found in the brains of patients with Parkinson’s disease and other sy...

Have a look at our new preprint on alpha-Synuclein acetylation.
www.biorxiv.org/content/10.1...

We are looking for talented international PhD students and postdoctoral researchers - www.mcgill.ca/edwardfonlab/

LRRK2 Kinase Mediates Increased GCase Activity in Microglia in Response to Proinflammatory Stimuli Variants in the LRRK2 and GBA1 genes are among the most common risk factors associated with Parkinson's disease (PD). Both patients carrying PD-associated variants in GBA1, encoding lysosomal enzyme g...

Emma MacDougall’s paper showing the interaction between the two PD genes, LRRK2 and GBA1, in human iPSC microglia is now online can01.safelinks.protection.outlook.com?url=https%3A...

Shout out to our collaborators Nicholas Silver and Joel Watts on the paper!

α-Synuclein purification significantly impacts seed amplification assay performance and consistency α-Synuclein seed amplification assays are a promising diagnostic tool for synucleinopathies such as Parkinson disease and multiple system atrophy. Standardized conditions are required to ensure a high...

Zaid Al-Azzawi’s paper showing the importance of the alpha-Synuclein purification method on the consistency of the Seed Amplification Assay (SAA) is now online. www.biorxiv.org/cgi/content/...

Midbrain organoids with an SNCA gene triplication display dopamine-dependent alterations in network activity Human midbrain organoids (hMOs) show promise as a patient-derived model for the study of Parkinson's disease (PD). Yet, much remains unknown about how accurately hMOs recapitulate key features of PD i...

Ghislaine Deyab’s paper showing that midbrain organoids from patients with Parkinson’s disease exhibit hallmarks of network activity abnormalities seen in vivo is now out on biorxiv. www.biorxiv.org/cgi/content/...

Just got around to closing my X account!

The Quebec government has awarded $1.6M to three McGill researchers to support projects advancing genomics, imaging, and manufacturing. These initiatives will foster collaborations and deliver significant benefits to Quebec and beyond.

➡️ mcgill.ca/x/wr8

A person is pictured walking in front of a building with pillars on Harvard University’s campus in Cambridge, Massachusetts. Headline reads: "Colleges Warn Foreign Students to Get to Campus Before Trump Takes Office." Photo credit: Adam Glanzman for The New York Times.

A number of colleges, including Harvard, USC and Cornell, are advising their international students to return to campus before President-elect Donald Trump is inaugurated on Jan. 20. nyti.ms/41qkzft

Mood in Montreal today.

Lab-grown brain cells help uncover new targets for Parkinson’s treatments.

🧠 Researchers at The Neuro have uncovered a new link between the immune system and the development of the disease.

➡️ mcgill.ca/x/wDZ

Great work! Congratulations to Peter McPherson and Team!

Financement de 1,5 million de dollars pour un projet de science ouverte La plateforme de caractérisation des anticorps YCharOS s’attaque à la « crise de la reproductibilité » dans la recherche Le gouvernement du Québec par l’intermédiaire du CQDM vient d’octroyer une…

Le Gouvernement du Québec, par l’intermédiaire du CQDM, octroya une subvention de 1,5 million pour la plateforme YCharOS. Ce projet dirigé par les neuroscientifiques @peter-mcpherson.bsky.social et Carl Laflamme, valide des réactifs d’anticorps pour les protéines humaines.
https://buff.ly/3OjmpXD

Félicitations!

Our new paper on Cathepsin B in Parkinson’s just published rdcu.be/d1sJ2