Nischal Ranganath

@absteward.bsky.social

From Chart Biopsy to Liquid Biopsy: Evaluating the Diagnostic Yield and Clinical Impact of Plasma Microbial Cell-Free DNA Next-Generation Sequencing in the Management of Fever of Unknown Origin Microbial cell-free DNA next-generation sequencing (mcfDNA-NGS) had a positive diagnostic impact in 30% of patients with fever of unknown origin (FUO). Pre

@ofidjournal.bsky.social
Take a read of our recent study assessing use of mcfDNA-NGS relative to standard testing in the workup of FUO. Molecular testing offered earlier time to diagnosis and some interesting non-hypothesis driven diagnoses.

academic.oup.com/ofid/article...

Concordance of non-invasive plasma cell-free DNA with invasive diagnostics for diagnosis of invasive fungal disease Mold plasma cell-free DNA (cfDNA) PCR is a promising non-invasive diagnostic modality for early diagnosis of invasive mold disease (IMD) in immunocompromised patients. Although mold cfDNA PCR has been shown to be highly accurate, the value of invasive procedures to collect specimens for conventional fungal diagnostics following plasma cfDNA testing remains unclear.

Concordance of non-invasive plasma cell-free DNA with invasive diagnostics for diagnosis of invasive fungal disease

✅ Just Accepted

Wow,timely!
Spinal implant infections are a serious complications of instrumented spinal fusion surgeries,carrying high morbidity & complex management challenges
🆕️🔥State-of-the-Art Review: Diagnosis and Management of Spinal Implant Infections #idsky #EMIMCC #medsky
academic.oup.com/cid/article/...

🆕️✨️The largest study to date of patients with Bacteroides spp. bacteremia in ISAC Journal, IJAA.

#IDsky

When Can a MRSA Nares Swab Guide Antibiotic Stewardship? This Clinical Insights discusses how the methicillin-resistant Staphylococcus aureus (MRSA) nares swab may be used alongside disease prevalence and clinical factors to determine when MRSA coverage is ...

🆕🔥Clinical Insights #JAMAInternalMed
When Can a MRSA Nares Swab Guide Antibiotic Stewardship?
What the Nose Knows #idsky #medsky #AMSsky #EMIMCC
jamanetwork.com/journals/jam...

I love it🔥
ASymptomatic Bacteriuria #idsky #medsky #utisky #AMSsky

Graphical abstract for the article "State-of-the-Art Review: Ocular Infections"

New in @cidjournal.bsky.social

State-of-the-Art Review: Ocular Infections

Miriam Barshak and multidisciplinary team

#IDSky #OphthoSky #MedSky @nottheogdrv.bsky.social

academic.oup.com/cid/article/...

If you have access listen to #IDweek presentation in the Era of shorted is better. @maricarmalinis.bsky.social #TxID #IDSky

A summary table on published observational studies on treatment duration of bloodstream infections in hematology patients with high-risk neutropenia. References: doi: 10.1007/s10096-024-04885-w doi: 10.1111/tid.14085 doi: 10.1016/j.jinf.2021.10.017 doi: 10.1093/cid/ciad605 doi: 10.1093/ofid/ofaa246

A summary table on published observational studies on treatment duration of graft infections on solid-organ transplant recipients. References: doi: 10.1111/tid.13896 doi: 10.1111/tri.14144 doi: 10.1111/tid.13868 doi: 10.1111/tid.13518

#ShorterIsBetter in immunocompromised hosts?
Short treatments are feasible in early responders without source control issues.

A significant number of observational studies serve as proof-of-concept on the feasibility of short courses in selected patients (see ⚠️)

#AMSsky #IDOnc #TxID #IDsky

ABX durations for secondary peritonitis and acute cholecystitis and cholangitis

🌟 ABX Pearl of the Day: Duration of treatment in intra-abdominal infections (IAI)! 💊

💡 Q: How long should I treat IAI after source control?
🔍 A: While STOP-IT trial calls for 4 days post-source control, there are notable exceptions. See infographic for details 👇
#IDsky #AMSsky #MedSky #Pharmsky

Join us in Hawaii (or via livestream) on Feb. 3-7 for Infectious Diseases Practice Updates 2025! Our outstanding @MayoClinicINFD faculty will cover updates on best practices and new developments in the field. Register here: tinyurl.com/2d7tkz6x

Antibiotic Treatment for 7 versus 14 Days in Patients with Bloodstream Infections | NEJM Bloodstream infections are associated with substantial morbidity and mortality. Early, appropriate antibiotic therapy is important, but the duration of treatment is uncertain. In a multicenter, non...

🆕 Just published in NEJM!

The BALANCE trial definitively establishes 7-day treatments as the standard of care for uncomplicated BSIs, with more than 3,600 randomized patients.

Fantastic work! @drtoddlee.bsky.social
www.nejm.org/doi/full/10.... #AMSsky #IDSky #ShorterIsBetter

Evaluating antimicrobial duration for Gram‐negative bacteremia in patients with neutropenia due to hematologic malignancy or hematopoietic stem cell transplantation In the management of immunocompromised patients with neutropenia and Gram-negative bloodstream infection, short antimicrobial courses (≤10 days) had comparable propensity score-adjusted 90-day outcom...

Congratulations to @nischalr3.bsky.social and his team for their paper being selected as the @thetxidjournal.bsky.social 2024 Bob Rubin Clinical Impact Awardee - this award selects the paper felt to have the biggest impact on clinical care in #TxID!

#IDSky

onlinelibrary.wiley.com/doi/10.1111/...