And of course, it's open source 🎉
github.com/MELDProject/...
We hope MELD-PostOp becomes a valuable tool for the epilepsy community. Huge congratulations to Jieun and the whole MELD team!
Results: median Dice of 0.85, sensitivity in 99% of patients, significantly outperforming existing approaches. It generalises to unseen test sites and takes only 17 seconds to run 🏎️💨 4/5
We trained a MELD-PostOp model on 965 postoperative MRI scans from 27 international centres.
Children and adults ✅
Temporal and extra-temporal resections ✅
1.5T and 3T scanners ✅
Real-world heterogeneity ✅✅✅ 3/5
After epilepsy surgery, accurately measuring what was removed is crucial for understanding outcomes. But manual tracing of resection cavities is slow, labour-intensive, and varies between raters, and existing automated methods weren't reliable enough. 2/5
🧵 Excited to share new work from the MELD project!
The fantastic Jieun Seo has created MELD-PostOp, a deep learning tool for automatically segmenting resection cavities on post-surgical epilepsy MRI. 1/5
@sophieadlerwagstyl.bsky.social @mathrip.bsky.social so many wonderful MELD collaborators
Is AI making job recruitment less meritocratic? We're getting some v interesting research studies on this question now, and the news is... not good. @jburnmurdoch.ft.com & I dive in, in the latest edition of our newsletter The AI Shift www.ft.com/content/e5b7...
The power of combining expert review and MELD GRAPH AI software in FCD hunting : Epi case, always reported negative, EEG/semiology non-conclusive, suspicious area found on exp rev confirmed by MELD! @ilae-epilepsy.bsky.social @esnr.bsky.social @konradwagstyl.bsky.social @mathrip.bsky.social
Great to see MELD Graph being put to use by the team at Great Ormond Street @greatormondst.bsky.social
Find out more here : jamanetwork.com/journals/jam...
To give MELD a try: meld-graph.readthedocs.io/en/latest/in...
@mathrip.bsky.social @sophieadlerwagstyl.bsky.social
Still time to apply to do a PhD with us on AI, Epilepsy & Neurodevelopment
Deadline March 30th
Apply here: shorturl.at/Zb4GX
Looking forward to returning to the FIL to catch up with some amazing former colleagues and share our latest MELD work at the Brain meeting
🚀 Fully Funded PhD – AI & Neurodevelopment @ KCL! 🧠💡
Come join us in the IMAGINE lab to develop AI tools for imaging and genetics in neurodevelopmental disorders!
Apply here: shorturl.at/Zb4GX
For more info, get in touch: konrad.wagstyl@kcl.ac.uk
Really exciting to have our new AI tool, MELD Graph, featured on BBC News - Epilepsy AI tool detects brain lesions doctors miss
www.bbc.com/news/article...
🤩 brilliant scientists elegantly achieving clinical impact for epilepsy through neuroimaging & AI ⬇️
Huge congrats @sophieadlerwagstyl.bsky.social @konradwagstyl.bsky.social and team !
DREAM TEAM - truly @konradwagstyl.bsky.social and @sophieadlerwagstyl.bsky.social have had an incredible vision for MELD for many years now.
And of course thank you to @mathrip.bsky.social and @hannahspitzer.bsky.social for all their analysis / coding / writing - the works!
5️⃣Finally, MELD Graph was a huge team effort with @konradwagstyl.bsky.social, @sophieadlerwagstyl.bsky.social, @hannahspitzer.
and our MELD consortium (@drfelicedarco.bsky.social @nathantcohen.bsky.social @metricsemma.bsky.social @kirstiejane.bsky.social @lzjwilliams.bsky.social + many others!)
Heterochronous laminar maturation in the human prefrontal cortex https://www.biorxiv.org/content/10.1101/2025.01.30.635751v1
🚨WE'RE HIRING !!! 🚨
Do you fancy tackling big questions wt unique combinations of clinical, neuroimaging & genomic data ?
We're for a passionate, dynamic & collaborative Data Scientist to join our team !
Job posting: www.nimh.nih.gov/about/career...
Lab info: www.nimh.nih.gov/research/res...
Dr Mathilde Ripart showcasing early work using #AI for multipathology detection in focal epilepsies #AES2024
Interested in joining the MELD Project or trying out the tools for FCD or HS detection? Come chat to us #aes2024 after the presidential symposium or at the posters! @konradwagstyl.bsky.social
Just in time for #AES2024, let's grow this list of epilepsy imagers! go.bsky.app/HnaoTqF
Thrilled to meet up with great friends and colleagues at #AES2024 in LA this week + good excuse to engage more w/ BlueSky! Don’t miss our session on Advanced Neuroimaging for Personalized Epilepsy Surgery—designed for clinicians & researchers, including patient testimony
@amepilepsysoc.bsky.social
🚨📣Job ad 📣🚨
Interested in a post-doc creating machine learning tools for neurodevelopmental disorders? Come work with us at the IMAGINE lab!
www.kcl.ac.uk/jobs/100005-...
imaginelab.github.io
New questions:
1. How are these axes mechanistically linked?
2. Is it an atlas averaging effect - is there more nuance within individuals?
3. What tools & data do we need?
4. If lots of features co-correlate with pathology, which one best links to aetiology or potential therapeutic avenues?
A similar axis seems now to be showing up everywhere: from cellular morphologies and expression markers through to cortical myelination, developmental patterns ( eg @valeriejsydnor.bsky.social shorturl.at/5gShe). It seems to be a fundamental feature of how our brains are organised.
In this new paper: shorturl.at/NbNLN, Zhang et al., combined rsfMRI, bulk and single cell gene expression data and found distinctive cellular fingerprints at the poles of the sensory-association rsfMRI gradient. But....
Had a lot of fun writing this news & views article on Converging Cortical Axes with @bogglerapture.bsky.social
shorturl.at/LsB5p
Automated and Interpretable Detection of Hippocampal Sclerosis in temporal lobe epilepsy: AID-HS https://www.medrxiv.org/content/10.1101/2023.10.13.23296991v1
Hello!
I'm a scientist in London applying machine learning to neuroimaging and genetics to understand epilepsy and other neurodevelopmental disorders #Neuroskyence #AcademicSky
