Joaquin Pellegrini

Type I interferon signaling promotes early innate control of Borrelia burgdorferi infection https://www.biorxiv.org/content/10.64898/2026.02.13.705697v1

Such a fun collaboration with @mel-foulon.bsky.social from the TS lab 🤝-👀 We combined dual RNA-Seq 🧬 and advanced imaging 🔬 to uncover how intracellular compartmentalization drives niche-specific metabolic phenotypes in mycobacteria!!
Fantastic team effort ✨
#Tbsky #microsky

Membrane-associated effluxosomes coordinate multi-metal resistance in Mycobacterium tuberculosis - The EMBO Journal Bacterial pathogens must withstand metal-induced stress during infection, yet the mechanisms by which they sense and respond to toxic metal ions remain incompletely understood. Here, we uncover a prev...

🎉 𝐄𝐱𝐜𝐢𝐭𝐞𝐝 𝐭𝐨 𝐬𝐡𝐚𝐫𝐞 𝐨𝐮𝐫 𝐧𝐞𝐰 𝐩𝐮𝐛𝐥𝐢𝐜𝐚𝐭𝐢𝐨𝐧 𝐢𝐧 𝐓𝐡𝐞 𝐄𝐌𝐁𝐎 𝐉𝐨𝐮𝐫𝐧𝐚𝐥!

After 8 months of revision, our work is now online: shorturl.at/WHmFq

We uncover a previously unrecognized way that 𝑀𝑦𝑐𝑜𝑏𝑎𝑐𝑡𝑒𝑟𝑖𝑢𝑚 𝑡𝑢𝑏𝑒𝑟𝑐𝑢𝑙𝑜𝑠𝑖𝑠 survives toxic metal stress during infection.
...

🚨 Postdoc Opportunity – Pathogen-Host Interaction 🚨 (2.5y)

🦠 Join our team to uncover the molecular mechanisms of Y. pestis infection in fleas within a @anrs-mie.bsky.social PEPR-funded project!

🔬 Profile: PhD in microbiology

#Postdoc #Microbiology #YersiniaPestis #ResearchJobs

💡Our webinars are back!
Don’t miss our session on macrophage metabolism this September 18th at 1:00 PM CET.

Stoyan Ivanov (Research Director; C3M, Nice) and Malvina Seradj (Postdoc; Institute of Cancer Research, London).

🔗 Register here: tinyurl.com/2feve67c

Over the last months I've been preparing important presentations. No matter the outcome, I'm very pleased to find many people willing to help and collaborate 🙏🙏 This is the way to build a strong scientific community

Neutrophils from tuberculosis patients are polarized toward pro-inflammatory and anti-inflammatory phenotypes according to the disease severity Abstract. Neutrophils are the first line of defense against pathogens, combating them by using several antimicrobial mechanisms. These cells display a rema

New in The Journal of Immunology !📢

Neutrophils from tuberculosis patients are polarized toward pro-inflammatory and anti-inflammatory phenotypes according to the disease severity

👉

academic.oup.com/jimmunol/adv...

pDCs and antibacterial response? Check out this paper ⬇️
Congratulations @joaquinpellegrini.bsky.social and all the authors involved! @ciml.bsky.social

Thanks for highlighting our work!

In a study led by Jean-Pierre Gorvel and Sylvie Mémet, CIML researchers found that SLAMF receptors shape human plasmacytoid dendritic cell responses to intracellular bacteria. Congrats to 1st author Joaquin Pellegrini and collaborators.
www.jci.org/articles/vie...
@jclinical-invest.bsky.social

Proud to share our work! 🧫😍
A special one!

Using Salmonella and Brucella, this study provides the first demonstration of an antibacterial response in pDCs orchestrated by SLAMF7 and SLAMF8, driving cytokine responses and favoring bacterial survival via mtROS control.

www.jci.org/articles/vie...

154 million lives and counting: 5 charts reveal the power of vaccines

www.nature.com/articles/d41...

🚨 Groundbreaking study reveals how hypoxia shapes immune cell organization in #Tuberculosis granulomas, promoting Mtb persistence. Targeting these metabolic niches could revolutionize TB treatment strategies. A technical tour de force and a major scientific advance!
📖 shorturl.at/WkTgq

Join us today!

📢 The next FCYI webinar on Intestinal Immunology is happening on 🗓️ Thursday, Feb 6th at 5 PM on Zoom 👩‍💻

Speakers:

🎙️ Julien Mambu (Postdoctoral researcher, CIML, Marseille)
🎙️ Valentin Thevin (Postdoctoral researcher, Department for Biomedical Research, Bern)

➤ Register here: tinyurl.com/2ma5d7tv

The French Club of Young Immunologists is now in BlueSky!

Under the aegis of the French Society for Immunology, it aims to bring together young scientists of French nationality or working in France in the field of immunology 💉🇨🇵🧫

@fcyimmuno.bsky.social
Follow the new account!

Besides imaging with Lysotracker, you might want to evaluate their function using DQ-BSA (degradation in lysosomes results in the release of fluorescent fragments) in the presence or not of Baf A1. TFEB and related target genes are use to follow lysosome biogenesis

Registration is live!! May 30th deadline for #EMBOTissueImmunity in Basel🇨🇭 (home to Eurocup 2025, Eurovision 2025, Art Basel, world renowned architecture and muuuuuch more!) Be our guest for groundbreaking #immunology discussion, swimming & fun along the Rhine.
meetings.embo.org/event/25-bar...

Can you ask AI to play a cumbia? 🤔🤔🤔🧫🧫📈📈

Brucella abortus impairs T lymphocyte responsiveness by mobilizing IL-1RA-secreting omental neutrophils - Nature Communications In this study, authors identify the omentum, a tertiary lymphoid organ part of the fat tissue, as a reservoir for Brucella abortus, which promotes bacterial persistence and causes CD4+ and CD8+ T cell...

In a study led by Sylvie Mémet and Jean-Pierre Gorvel, CIML researchers identified a new pathway by which Brucella abortus escapes host immune responses in the visceral fat. Congrats to 1st authors Joaquin Pellegrini, Gabriela González and all collaborators. Check the study: @naturecomms.bsky.social

My favorite is n°5 (song and science)

They're back!

Join us for the next FCYI immuno webinar. Excellent talks for granted!

Brucella abortus impairs T lymphocyte responsiveness by mobilizing IL-1RA-secreting omental neutrophils - Nature Communications In this study, authors identify the omentum, a tertiary lymphoid organ part of the fat tissue, as a reservoir for Brucella abortus, which promotes bacterial persistence and causes CD4+ and CD8+ T cell...

The omentum, a reservoir for B. abortus, promotes bacterial persistence and causes CD4+ and CD8+ T cell immunosuppression by IL-1RA secreted by PD-L1+Sca-1+ neutrophils
nature.com/articles/s41...
@naturecomms.bsky.social @joaquinpellegrini.bsky.social

Brucella abortus impairs T lymphocyte responsiveness by mobilizing IL-1RA-secreting omental neutrophils - Nature Communications In this study, authors identify the omentum, a tertiary lymphoid organ part of the fat tissue, as a reservoir for Brucella abortus, which promotes bacterial persistence and causes CD4+ and CD8+ T cell...

I'm very glad to share our last work, now online:

The omentum, a new reservoir for B. abortus, promotes bacterial persistence and causes CD4+ and CD8+ T cell immunosuppression by IL-1RA secreted by PD-L1+Sca-1+ neutrophils.

www.nature.com/articles/s41... @ciml.bsky.social

Good lyrics Rafa!

Pertussis is awful even if you’re not at high risk, but it literally kills and disables babies. The vaccines are not perfect, but keeping up to date and getting boosted in pregnancy is critical.

Insights: Nikhil Jiwrajka & @montserrat-anguera.bsky.social discuss study of plasmacytoid dendritic cells from #SystemicSclerosis patients by Du et al. (https://buff.ly/3Cf8uQ8) that suggests the X chromosome plays a key role in the sex bias of this autoimmune disease. https://buff.ly/4jnpjc2

Happy to share our latest @biorxiv-plants.bsky.social led by @manuelgonzalezfuen.bsky.social “Effector-triggered processing body formation attenuates host translation via ER stress responses and autophagy upon bacterial infection” #proteostasis #plantimmunity 🧵(1/16)
www.biorxiv.org/content/10.1...

Representing the @FCYImmuno at the 27th congress of the French Cytometry Association (AFC🇨🇵) in Marseille. Excellent talks this morning during the Young Scientists session.

Undernutrition is a key driver of TB accounting for 1/5 cases, but relationship is poorly understood. New sys review of this based on 42 studies (>26 million people) by Matt Saunders et al:
papers.ssrn.com/sol3/papers....

@reinhouben.bsky.social
@raclark18.bsky.social
@lshtm-tbmod.bsky.social