Quick plug for our new resource, the Drosophila Species Stock Exchange. This is a database and mailing list that documents species currently in culture and the labs holding them. If you want to know more or sign up then please get in touch. See attached for more info and please share!
Excited to be presenting my work at #ASBMB26 on how glucose metabolism interacts with mTor signaling in #Drosophila in the Integrated Metabolism session on March 9 at 2.50 pm in the Cherry Blossom room.
It's my first time attending #ASBMB and we are having a wonderful time here in DC ☺️
Picture of Sarah
Talk slide title with images of testis defects
If you're at #Dros26 and are interested in how cells change shape & move during morphogenesis & how different classic cadherins influence different cell behaviors, check out the talk by @saraheclark.bsky.social in Cell Biology: Cytoskeleton, Organelles, & Trafficking II Sat 9:15 🧪
Me too 😭
Excited to share our work at #DROS26!
I’ll be giving a talk today at 11 AM in the Patterning, Morphogenesis, and Organogenesis session.
Also come check out posters from our lab: Elizabeth (F 2-4 pm), Debbie (S 1:30-3:30 pm)
Best wishes for your talk, Shefali!
Many congratulations to you! 🎉
New preprint out!
In this study, we introduce NanoFLex, a strategy that combines #HaloTag variants with #nanobodies -based immunolabeling to enable rapid, OneStep-IF #lifetime #multiplexing. Possible due to SmartSecondaries fused to #HaloTag from @nanotag.bsky.social: www.biorxiv.org/content/10.6...
ShineGAL4 FLP-out clones
#Drosophila calling. Delighted to share our new collection of ShineGAL4 drivers for CNS, FB, muscles, enterocytes, oenocytes and MTs made by @vgirard.bsky.social, @sebsorge.bsky.social and colleagues @crick.ac.uk. All at Bloomington @bdsc.bsky.social
@dev-journal.bsky.social
tinyurl.com/4jpw9jd6
Excited to have started my new lab in Human Genetics at Pitt Public Health!
We study wound healing in diabetes & aging using adult zebrafish. Check out this movie showing neutrophil dynamics after injury.
Now recruiting research staff, grad students, and postdocs. DM me if interested.
Many congratulations, Leah! Best wishes for the exciting times ahead 🎉
And if you wanted proof ... @dev-journal.bsky.social
I love GFP
Left: This image visualizes the precise retinal mosaic formed by ultraviolet-sensitive cone (red) cells in zebrafish, highlighting the organized cellular landscape that underlies this research. Right: This image highlights the abundant cone population in the adult zebrafish retina, with UV-sensitive cones distributed throughout the tissue. The visualization, achieved using the Tg(sws1:GFP) transgene to label UV cone cell bodies. Creator: Jingjin Xu.
#Photoreceptor cells vary in the morphology of the light-absorbing outer segment, but why? This study in #zebrafish shows that the wavelength sensitivity of the expressed #opsin and the intensity of light exposure determine outer segment morphology @plosbiology.org 🧪 plos.io/4aKJi15
Happy to share scHiCAR, an ultra-high throughout (millions of cells), low cost (5 cents/cell including NGS), and trimodal platform for integrated single-cell level analysis of mRNA, open chromatin, and 5-kb resolution looping with ground-truth data the same individual cell.
Time-calibrated phylogeny of the family Drosophilidae showing major species groups, surrounded by representative adult flies that highlight the remarkable morphological diversity of this model insect group. The composite image was created using Microsoft PowerPoint. Fly photographs were taken by Darren J. Obbard and are published under the Creative Commons Attribution License with permission.
The #fly community aims to achieve a comprehensive genomic study of the Drosophilidae family. @pankajd.bsky.social @bernardkim.bsky.social @petrovadmitri.bsky.social @darrenobbard.bsky.social present a comparative gene annotation for 301 #Drosophilidae species @plosbiology.org 🧪 plos.io/4c3pyrI
New preprint @biorxiv-devbio.bsky.social by Harshath Amal and colleagues from our lab @uni-muenster.de shows how a BMP #morphogen gradient is translated into graded junctional permeability by tuning adhesion and actomyosin contractility in #Drosophila
See tinyurl.com/yhbwd9xh
@sfb1348.bsky.social
Cells come in many shapes and sizes, with diverse physiological functions. But how do #organelles and their interaction networks remodel during #differentiation of stem cells into different cell types? Here’s what we discovered about neuronal differentiation: 1/13
Development builds... But it also breaks!
Planarians split to reproduce. Hydra tears open a mouth. Embryos fracture to make cavities.
Failure? No. Fracture is essential to development.
Our new review on fracture physics and its uses in development:
journals.biologists.com/dev/article/...
Our uncorrected spoof, I mean proof! More forays into lipids and sensors and the intricacies of membrane trafficking. Thanks again to three reviewers for authentically helping us make this a better manuscript. Peer review is essential.
dx.plos.org/10.1371/jour...
Our take on a really interesting new study by the Franz lab at UCL, a version of epithelial polarity where you would not expect it! Read our Spotlight and the original paper!
Excited to share our work on epithelial multilayering - identifying why stem cell stay in the basal layer and how and why differentiating cells move up. Great collab with @manningresearch.bsky.social and Niessen labs! Check out preprint and great summary below www.biorxiv.org/content/10.6...
In @elife.bsky.social: A high-resolution, easy-to-build light-sheet microscope for subcellular imaging doi.org/10.7554/eLif...
Hello epithelial mechanics fans!! I’m Juanma @juanmagararc.bsky.social 👋 I work on cell mechanics (see celldynamicslab.com) and use Flipper-TR FLIM to probe membrane biophysics in cells.
Join me on this tour about Flipper: what it measures, strengths, advice, cool case studies, and cute drawings!
How do compartmentalization & loop extrusion organize eukaryotic genomes beyond classical model organisms?
Hi-C analysis of silkworm chromosomes by Drinnenberg, Muller, Mirny et al reveals new combination of these mechanisms, and a new, secluded “S” compartment
link.springer.com/article/10.1...
The first paper from the lab is now out in Science Advances: Multimodal social context modulates larval behavior in Drosophila
www.science.org/doi/10.1126/...
We find that fly larvae keep their distance to conspecifics in the absence of food, enjoy reading! @cbehav.bsky.social @uni-konstanz.de
Happy to announce that our latest paper is now out! Have you ever wondered how neural tissues control their size? In this paper, we show that cell division orientation is critical in both the cortex and retina. www.science.org/doi/10.1126/...
New paper alert!🤩Super proud that our story led by superstar postdocs @liujinghui.bsky.social and @nerlielisa.bsky.social is finally out! We found how electrical signals are key for promoting organ regenerative growth!!! A thread 🧵https://www.science.org/doi/10.1126/sciadv.aec0687
Lipocalins and Scavenger Receptors affect the luminal matrix that prevents narrow tubes from collapsing - now in press in Development! #aECM #Celegans
journals.biologists.com/dev/article/...
How can embryos use pulsatile contraction to shape tissue development during morphogenesis? I'm @weiyiqian.bsky.social and with this thread I want to introduce the roles of pulsatile actomyosin in animal development and the mechanisms that drive actomyosin to pulse
