C.M.Hammell@CSHL

A developmental timer coordinates organism-wide microRNA transcription

MYRF-1/LIN-42 timing complex controls temporal patterning!

www.biorxiv.org/content/10.6...

The latest work from the Hammell lab is out! Super-convergence of all the projects in our lab with some excellent collaborations with the Ercan (NYU) and the Joshua-Tor (CSHL) labs!

Bluesky-torial to come!

www.biorxiv.org/content/10.6...

Cohesin organizes 3D DNA contacts surrounding active enhancers in C. elegans - PubMed In mammals, cohesin and CTCF organize the 3D genome into topologically associating domains (TADs) to regulate communication between <i>cis</i>-regulatory elements. Many organisms, including <i>S. cere...

our latest work summary: cohesin is preferentially loaded at/near active enhancers and loop extrudes in both directions, forming loops that create the dna contacts that appear as the newly defined "fountains" in hic maps pubmed.ncbi.nlm.nih.gov/40210441/

Ha. Idiots!

Kickass worm-friend @rnareylab.bsky.social wrote a piece for @sciencehomecoming.bsky.social and you should read it and send it to your red-state friends and fam. Hurting research hurts all of us. #invertsolidarity 🧪 www.heraldbanner.com/opinion/colu...

www.nopatientleftbehind.org/defending-th...

Opinion | American Science is Under Attack The Trump administration hobbles research and endangers the public health.

www.nytimes.com/2025/02/14/o...

Alumna of the Postbaccalaureate Research Education Program (PREP) at UMass Chan in the lab

The Postbaccalaureate Research Education Program at UMass Chan prepares students with a bachelor’s or master’s degree for doctoral study in the biomedical sciences through a yearlong, mentored research project. Apply by Feb. 28: direc.to/mqhT

#MolecularGenetics #CellBiology #PublicHealth

What an amazing discovery from Scott Kennedy's lab! A new splicing system that recognizes transposons and removes them from mRNAs! t.co/3p3wyxkYXX

www.embopress.org/doi/epdf/10.....
Please check out Xuhang's exciting article in MSB!

👇🏻👇🏻

Your Action Is Needed!

Congress needs to hear from scientists. Call your representatives to oppose funding freezes and restrictions on research. Find contact info at govtrack.us and make your voice heard today! #SciencePolicy

www.ascb.org/science-poli...

It’s been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendritic cell sarcoma (IDCS). I’m reaching out to identify clinicians/patients who have encountered pediatric IDCS or other (non-LCH) dendritic or histiocytic sarcomas cases.

Trump Administration Cuts Put Medical Progress at Risk, Researchers Say Grants from the National Institutes of Health come with additional money for overhead. A planned $4 billion cut would leave colleges with large budget gaps.

NY Times:

www.nytimes.com/2025/02/07/u...

FBI Uncovers Al-Qaeda Plot To Just Sit Back And Enjoy Collapse Of United States WASHINGTON—Putting the nation on alert against what it has described as a “highly credible terrorist threat,” the FBI announced today that it has uncovered a plot by members of al-Qaeda to sit back an...

FBI Uncovers Al-Qaeda Plot To Just Sit Back And Enjoy Collapse Of United States

Very cool paper!!!

Indeed! Cool paper!

Itziar Pinilla-Macua, Sachin Surve and Alexander Sorkin find that that signalling through the EGFR-VAV2-Rac1 pathway persists in endosomes and is required for EGFR-driven cell migration.
#OpenAccess
Highlight: journals.biologists.com/jcs/article/...
Article: journals.biologists.com/jcs/article/...

So cool!

All of these podcasts are fantastic. Try them out!

Genetic coupling of enhancer activity and connectivity in gene expression control - Nature Communications Here, the authors study the effects of expression quantitative trait loci on enhancer activity and promoter contacts in primary monocytes isolated from male individuals, suggesting an inherent genetic...

Our new paper is finally out, showing that the same enhancer sequences - and likely the same transcription factors recruited to them - affect the activity of distal enhancers and their looping over to target gene promoters.

www.nature.com/articles/s41...

Dr Phil joins Chicago immigration raid as border czar says more arrests coming TV personality embeds in one of several raids in US cities in what Tom Homan says are only ‘beginning stages’

“Dr Phil joins Chicago immigration raid…” ….headline says it all.

Great meeting! Register now!

Spotlight: Edward Courvan and Roy Parker @colorado.edu discuss new work from Escayola, Zhang, @karlaneugebauer.bsky.social and colleagues (https://buff.ly/4fPlwBt) that carefully profiles Cajal Body components and finds an unexpected role for 60S ribosomal proteins. https://buff.ly/40rjnaD

It's still true that no philosopher has had a bigger impact on science than Popper, who argued that we should make risky and bold predictions to test our ideas. Do the killer experiment, he would say; the one that has a chance to kill your hypothesis.

Nuclear sorting of short RNA polymerase II transcripts The majority of initiating RNA polymerase II (RNAPII) terminates early, generating an abundance of short RNAs that require sorting into productive or destructive pathways. Here, Garland and Jensen explore early quality-control mechanisms that govern the fate of short RNAs, preventing the accumulation of non-functional transcripts and ensuring proper RNA processing.

www.cell.com/molecular-ce...

Trump Sees the U.S. as a ‘Disaster.’ The Numbers Tell a Different Story. President Biden is bequeathing his successor a nation that by many measures is in good shape, even if voters remain unconvinced.

Same in America: www.nytimes.com/2025/01/05/u...

Noncanonical role of ALAS1 as a heme-independent inhibitor of small RNA–mediated silencing microRNAs (miRNAs) and small interfering RNAs (siRNAs) are 21- to 22-nucleotide RNAs that guide Argonaute-class effectors to targets for repression. In this work, we uncover 5-aminolevulinic acid synt...

ALAS1 acts as an inhibitor of the miRNA pathway in the cytoplasm. Normally ALAS1 acts in mitos in heme synthesis. Great work from @lucksmith.bsky.social

www.science.org/doi/10.1126/...