Haaris Ahsan Safdari

If you are looking for a PhD with great science, great people, and great views of Hamburg, here is your chance! (In the lab of my wonderful former supervisor).

VitriFlex: An Open-Source, Modular, and Customizable Robotic Platform for Cryo-EM Grid Preparation www.biorxiv.org/content/10.1101/2025.07.24.666634v1 #cryoEM

Preprint from our collaboration with the labs of Gerry Wright and Shura Mankin identifying the first translation inhibitor binding to the E-site of the bacterial ribosome… www.researchsquare.com/article/rs-6...

All was good 👍

Thanks very much 😀

Thanks Daniel @wilsonlab.bsky.social Credit goes to all your support and supervision!

Excited to share that I received the Best Poster Prize at Translation UK 2025 in Edinburgh!
Grateful to the @biochemsoc.bsky.social and Bioscience Reports for supporting young researchers.
#TranslationUK2025 #StructuralBiology #CryoEM

New preprint alert!

Read about Manikomycin, a hidden antibiotic from Streptomyces rimosus that targets the ribosomal E site, revealing a novel MOA against MDR pathogens.
Even old strains have surprises.

🧬💥 doi.org/10.21203/rs....
#Antibiotics #CryoEM #Microbiology

Heading to #TranslationUK2025?

Come find me at Poster P002 – I’ll be showing how kasugamycin, edeine & GE81112 target different steps of 30S initiation complex formation 🧬

Let’s chat ribosomes, antibiotics & translation! @biochemsoc.bsky.social

#BiochemEvent #SciComm

🧬 Spoke at the 2nd Polish RNA Biology Meeting in Poznań!

Presented my PhD work on how kasugamycin, edeine & GE81112 disrupt distinct steps of 30S initiation complex formation using cryo-EM.

Grateful for the engaged crowd & vibrant discussions!

#CryoEM #RNA

We’ve uncovered Asgard chromatin structures formed by a Hodarchaeal histone : closed hypernucleosome conserved in archaea and an open form resembling the H3-H4 eukaryotic octasome. Fantastic work by @harshranawat.bsky.social!
www.biorxiv.org/content/10.1...
#Chromatin #Asgard #Archaea #cryoEM

Hey #TeamTomo,
Ever been in need of a tutorial about the fundamentals of cryo-electron tomography? From preprocessing raw frames to high-res subtomogram averaging?
That's why @florentwaltz.bsky.social and I made this website!

tomoguide.github.io

Follow the thread 1 /🧵
#CryoET #CryoEM 🔬🧪

The electron cryo-microscope adapted for use at liquid nitrogen temperatures within its custom-made black box.

A colder frontier in cryo-EM 🧪🔬

Chris Russo’s group, inc. Joshua Dickerson, adapted #cryoEM to work at liquid helium temperatures (13 kelvins), where every frame captured contains more information than the equivalent using liquid nitrogen (81 kelvins).

Read more: tinyurl.com/mwwcunkc

#LMBResearch

Structure of a Gcn2 dimer in complex with the large 60S ribosomal subunit | PNAS The integrated stress response (ISR) is a central signaling network that enables eukaryotic cells to respond to a variety of different environmenta...

Fresh off the press…our latest study on the Structure of a Gcn2 dimer in complex with the large 60S ribosomal subunit | great collaboration with inada and Zaher labs. Data collected by Bertrand Beckert at the DCI EPFL
www.pnas.org/doi/10.1073/...

Good luck @harrywilliams.bsky.social

Credit: Margot Riggi (@margotriggi.bsky.social), Max-Planck Institute of Biochemistry (@mpibiochem.bsky.social)

Asgard archaea have actin - but what about microtubules? Where do they come from? 🧐 Our new paper www.cell.com/cell/fulltex... by @xujwet.bsky.social & @florianwollweber.bsky.social, in collaboration with the Schleper & Wieczorek labs, describes tiny Asgard microtubules! #TeamTomo #ArchaeaSky 1/6

Image processing for cryo-electron microscopy Cryo electron microscopy (cryo EM) is a major structural biology method for studying macromolecular complexes and cellular structures in their native states. Stable high resolution cryo microscopes, …

We are thrilled to announce the 2025 EMBO practical course in cryo-em image processing, Birkbeck College, London, 9-16 Sept 2025. More info & apply: meetings.embo.org/event/25-cry... Organisers Giulia Zanetti & Helen Saibil. Beautiful image from co-organizer @carolynmoores1.bsky.social lab.

Exciting News! We’re thrilled to announce the first Functional Amyloid Meeting at DESY!

Join us for a deep dive into the latest breakthroughs in functional fibrils, with a spotlight on amyloid molecular and cellular mechanisms and their biomedical applications.

landau-cssb.de/meeting-of-f...

Blocking IF3N delays bacterial translation initiation Bacterial translation initiation factor IF3 is composed of two distinct domains, a well-characterized C-terminal domain (IF3C), which enhances the speed and fidelity of translation initiation, and a l...

www.biorxiv.org/content/10.1...

Blocking IF3N delays bacterial translation initiation www.biorxiv.org/content/10.1101/2025.03.14.643242v1 #cryoEM

The translation inhibitors kasugamycin, edeine and GE81112 target distinct steps during 30S initiation complex formation pubmed.ncbi.nlm.nih.gov/40075065/ #cryoEM

Thanks @emilgustavsson.bsky.social

Congrats to Haaris @haarissafdari.bsky.social for successfully defending his PhD thesis today - 2 days after his second first author paper came out! Good timing!

Fascinating things happening at the IIMCB nowadays! This is one of the first patterns milled with our new TFS Hydra Bio Plasma-FIB, and - most likely - the smallest IIMCB logo ever!

The translation inhibitors kasugamycin, edeine and GE81112 target distinct steps during 30S initiation complex formation - Nature Communications The antibiotics kasugamycin, edeine and GE81112, inhibit translation initiation. Here, the authors present cryo-electron microscopy structures of 30S initiation intermediate complexes with these drugs...

www.nature.com/articles/s41...

Thanks for sharing!

The translation inhibitors kasugamycin, edeine and GE81112 target distinct steps during 30S initiation complex formation - Nature Communications The antibiotics kasugamycin, edeine and GE81112, inhibit translation initiation. Here, the authors present cryo-electron microscopy structures of 30S initiation intermediate complexes with these drugs...

www.nature.com/articles/s41...

Full link: www.nature.com/articles/s41...

The translation inhibitors kasugamycin, edeine and GE81112 target distinct steps during 30S initiation complex formation - Nature Communications The antibiotics kasugamycin, edeine and GE81112, inhibit translation initiation. Here, the authors present cryo-electron microscopy structures of 30S initiation intermediate complexes with these drugs...

Excited to share my first-author paper in Nature Communications! Using cryo-EM, we reveal how kasugamycin, edeine, and GE81112 inhibit bacterial translation initiation by binding the 30S ribosomal subunit in distinct ways.

Read more: www.nature.com/articles/s41...