We also show serum from exercise trained individuals alters SIRT1 and glycolytic proteins in a genotype-dependent manner, but may require additional cues from exercise to decrease Alzheimer's disease pathologies.

We showed the APOE4 genotype directly impairs glucose metabolism and BMEC barrier function by reducing insulin signaling and SIRT1 protein levels compared to the APOE3 genotype.

I couldn't have asked for better collaborators and teammates from both UMD BIOE and UMD Kinesiology, and I'm so excited for this project to finally be out in the world!

Impacts of APOE-ε4 and exercise training on brain microvascular endothelial cell barrier function and metabolism The APOE-ε4 genotype is the highest genetic risk factor for Alzheimer's disease (AD), and exercise training can reduce the risk of AD. Two early patho…

Incredibly excited to share the crux of my thesis work that was just published in @ebiomedicine.bsky.social! We examined how APOE genotype and exercise training impact BMEC metabolism and function. www.sciencedirect.com/science/arti...