Sarah Jäkel

I have a question for the research commumity.
I am looking into buying a vibratome to prepare actute organotypic slices from mouse brains and I am unsure which brand to buy. Currently the choice is between Leica and Precisionary Instruments.
Amy recommendations?

It was a real pleasure to visit Hamburg and get to knowamy new people!

Thank you 😀

Are oligodendrocytes bystanders or drivers of Parkinson’s disease pathology? The major pathological feature of Parkinson ‘s disease (PD), the second most common neurodegenerative disease and most common movement disorder, is the predominant degeneration of dopaminergic neurons...

Did you ever wonder about the role of oligodendrocytes in Parkinson's disease? Check out our new unsolved mysteries article in collaboration with the Burbulla lab! It is quite certain that a lot of work moves in this direction.

journals.plos.org/plosbiology/...

Now you are an expert!

This work was a huge collaborative effort, it is a brilliant resource for many researchers, and I am really glad to see this out!

Thank you! This paper was literally just a by-product of our scientific work, but we and so many other people struggled to get meaningful results, so we thought we want to address this!

Hi Ethan, thanks for starting this, can you pleas add me here?

Impact of fixation duration on messenger RNA detectability in human formalin-fixed paraffin embedded brain tissue Hurler et al. performed RNAScope on post-mortem human brain tissue and found mRNA signal detection to be highly dependent on fixation time. Considering the

The first paper of the Jäkel lab is out!
We have shown that the RNA detection in human FFPE brain tissue significantly changes with fixation time. Chose your tissue well before doing an experiment!

doi.org/10.1093/brai...