Dr. Nicola Smyllie's Avatar

Dr. Nicola Smyllie

@nsmyllie

Investigator scientist at MRC Laboratory of Molecular Biology Neurobiologist researching the circadian clock of the suprachiasmatic nucleus STEM Ambassador Passion for Science Public Engagement All views are my own

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04.02.2025
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Latest posts by Dr. Nicola Smyllie @nsmyllie

Person on ladder adjusting clock hands against a sky transitioning from day to night.

Person on ladder adjusting clock hands against a sky transitioning from day to night.

New #LMBResearch led by @drbatmo.bsky.social in John O’Neill’s group (@cellbiol-mrclmb.bsky.social) has identified the molecular switch decides day or night.

Click here to read how the mTOR pathway controls when mammals are active and the role it’s played in evolution: mrclmb.ac.uk/news-events/...

27.02.2026 09:59 👍 8 🔁 5 💬 0 📌 2
Preview
A cellular basis for the mammalian nocturnal-diurnal switch Early mammals were nocturnal while dinosaurs dominated the daytime. Mammalian transition to daytime activity accelerated after the Cretaceous-Paleogene extinction, but the underlying mechanisms remain...

Since I moved to @mrclmb.bsky.social I’ve been trying to answer this: Why are some mammals active at night and others in the day? Today our answer is out @science.org www.science.org/doi/10.1126/....
If you’re interested in circadian biology, evolution or how timing shapes physiology, take a look

27.02.2026 11:29 👍 68 🔁 23 💬 7 📌 2
Research Associate in Circadian Mechanisms in Cardiometabolic Disease:Oxford Road Due to the nature of the funding, KTP Associates who have already completed a KTP are not eligible to apply.

4yr MRC-funded postdoc position investigating circadian mechanisms in cardiometabolic disease, currently available @manchester.ac.uk

www.jobs.manchester.ac.uk/Job/JobDetai...

Come and join our brilliant Centre for Biological Timing team!

@bioclocksuk.bsky.social #chronobiology #circadian #postdoc

10.11.2025 12:51 👍 4 🔁 7 💬 0 📌 0
Microsoft Forms

Share you #chronobiology research at the upcoming #ClockClub in Nottingham on the 9th of January 2026. Only a few more days until the 14th Nov abstract submission deadline!
Send your abstract here: forms.office.com/e/cQDefteB7S

11.11.2025 10:42 👍 2 🔁 3 💬 0 📌 0
Join the LMB's PhD programme!
Applications now open for October 2026
Deadline 2nd December 2025

Join the LMB's PhD programme! Applications now open for October 2026 Deadline 2nd December 2025

Considering the LMB for your PhD?
We’ve got over 25 projects available, covering a wide array of topics. Check them out here: www2.mrc-lmb.cam.ac.uk/students/int...
Apply by 2nd DEC for Autumn 2026 admission.

10.11.2025 14:03 👍 7 🔁 9 💬 0 📌 1
M4S collage with past winners and in action pictures

M4S collage with past winners and in action pictures

The M4S Competition has expanded its reach to Birmingham and Manchester, underscoring the programme's success in sparking scientific curiosity among primary students across the UK
#LMBNews
www2.mrc-lmb.cam.ac.uk/m4s-expansio...
@mcrcnews.bsky.social @uom-dcs.bsky.social @unibirmingham.bsky.social

27.10.2025 14:20 👍 4 🔁 3 💬 0 📌 0
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MRC Laboratory of Molecular Biology - Beauty is in the detail - Peterborough STEM Festival Have a go at coding with Peterborough CoderDojo!

Join us at @pborostemfest.bsky.social on Oct 18 to test your detective skills in an interactive game, matching what you see under a microscope with different areas of LMB’s science #PSF2025

📍 ARU Peterborough
🕚 11:00 – 16:00 (Quiet time 9.30-11)

www.peterboroughstemfestival.co.uk/exhibitors/m...

13.10.2025 10:46 👍 5 🔁 2 💬 0 📌 0
Images of children and young people taking part in Public Engagement activities

Images of children and young people taking part in Public Engagement activities

Want to help inspire future generations of scientists? Are you passionate about #SciComm? We have a Public Engagement and Communications Officer (Maternity Cover) position in the LMB engagement & comms team:

www.reed.co.uk/jobs/public-...

Closes 21 SEP
#SciCommJobs

04.09.2025 08:59 👍 7 🔁 6 💬 0 📌 0
Michael Hastings in a light pink shirt stands with arms crossed in front of scientific research posters filled with charts and graphs.

Michael Hastings in a light pink shirt stands with arms crossed in front of scientific research posters filled with charts and graphs.

We’re looking for a #postdoc to join Michael Hastings’ group, studying diet-induced neuroinflammation in the hypothalamus and its modulation by circadian clock mechanisms, in collaboration with John O'Neill's group.
www.nature.com/naturecareer...
Closes 08 SEP
#ScienceJobs #PostdocJobs

20.08.2025 10:38 👍 2 🔁 4 💬 0 📌 0
Post image

☀️ Summer is a great time to observe biological rhythms in action. Look at the insect life around you - do they come out at a particular time of day?

🐝 If so, you've found their 'temporal niche'!

🔗 Learn more through our factsheets here: www.bioclocks.uk/factsheets

#SciComm #Ecology 🧪

11.08.2025 10:14 👍 5 🔁 4 💬 0 📌 0
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Could bridging science and the arts be the key to better policies? To be successful, policymakers need to consider diverse perspectives. Here’s how we’re reimagining policy process.

To be successful, policymakers need to consider diverse perspectives

go.nature.com/3H7XR3X

30.07.2025 10:18 👍 22 🔁 9 💬 1 📌 1
We're Hiring!
Science Photographer/Videographer
VisLab, MRC LMB
Bring science to life through stunning visuals.
Apply Today

We're Hiring! Science Photographer/Videographer VisLab, MRC LMB Bring science to life through stunning visuals. Apply Today

Are you creative? Curious? Science-savvy?
We have a unique opportunity to join the LMB’s VisLab as a Photographer / Videographer where you’ll help communicate ground-breaking research with dynamic visuals.
Apply now: mrc.tal.net/vx/mobile-0/...
#CambridgeJobs #PhotographyJobs #ScienceCommunication

22.07.2025 08:18 👍 2 🔁 2 💬 0 📌 0
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Is the next step of your career at the LMB?
Come and find us at the @cambridgebiocampus.bsky.social Campus Jobs and Career Fair this Saturday 21st June at the Cambridge Academy for Science and Technology!
More details here: cambridge-biomedical.com/event/cbc-jo...

17.06.2025 15:18 👍 1 🔁 3 💬 0 📌 0
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What does the evidence say about beating #jetlag? It depends which way you’re going!

Check out our full factsheet on Jetlag here: www.bioclocks.uk/factsheets

#chronobiology #scicomm 🧪

16.06.2025 15:49 👍 9 🔁 6 💬 0 📌 0
Preview
CRYing for balance: a repressor lingers through peak circadian transcription | The EMBO Journal EMBO Press is an editorially independent publishing platform for the development of EMBO scientific publications.

Thanks to Michael Brunner for writing this #news&views article for @embojournal.org about our recent research on #circadian clock protein dynamics in the SCN: www.embopress.org/doi/full/10....

10.06.2025 14:12 👍 2 🔁 1 💬 0 📌 0
Why I Work with Mice in Research - An Animal Technician's Point of View
Why I Work with Mice in Research - An Animal Technician's Point of View YouTube video by MRC Laboratory of Molecular Biology

The LMB is committed to being open & honest about why & how we use animals in our research.
Our Biological Services Group provide excellent care to our colonies of rodents – our fantastic animal technicians explain why they work with mice in this video: youtu.be/V7CHmPGjvSo
#BOARD25 @eara.eu

03.06.2025 08:30 👍 10 🔁 6 💬 0 📌 2

A nice summary about my latest paper, and I got to use this image that I had fun putting together (no AI in sight!)

25.04.2025 11:03 👍 3 🔁 1 💬 0 📌 0
Artistic representation of the complex dynamics exhibited by “clock proteins” within the brain.

Artistic representation of the complex dynamics exhibited by “clock proteins” within the brain.

Uncovering the hidden complexity behind the brain’s master clock.
New research led by @nsmyllie.bsky.social, in Michael Hastings’s group, reveals that body clock proteins PER2 & CRY1 act more independently than previously thought:
www2.mrc-lmb.cam.ac.uk/uncovering-t...
#LMBResearch 🧪 🕙 🧠

25.04.2025 10:44 👍 16 🔁 4 💬 0 📌 1
Preview
A cellular basis for the mammalian nocturnal-diurnal switch Early mammals were nocturnal until the Cretaceous-Paleogene extinction enabled diurnal niche expansion. Diurnality evolved multiple times independently, but the mechanisms driving this shift remain un...

If anyone is interested, I've updated our take on a cellular basis of the mammalian nocturnal-diurnal switch @biorxivpreprint.bsky.social

We've refined the paper (for the better, hopefully!) - my fave updates are the results from a collab with Zoonomia (Fig 3)

www.biorxiv.org/content/10.1...

24.04.2025 10:29 👍 5 🔁 1 💬 0 📌 0

Very pleased to see my latest paper out in @embojournal.org Go check it out!

24.04.2025 09:13 👍 3 🔁 1 💬 0 📌 0
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Quantitative measures of clock protein dynamics in the mouse suprachiasmatic nucleus extends the #circadian time-keeping model
Michael Hastings, Nicola Smyllie @nsmyllie.bsky.social et al @mrclmb.bsky.social
www.embopress.org/doi/full/10....

22.04.2025 10:49 👍 6 🔁 2 💬 0 📌 1
Girl and woman looking under a microscope in an outreach activity

Girl and woman looking under a microscope in an outreach activity

LMB scientists showcased their work at the @cambridgefestival.bsky.social with a hands-on activity about the scale of biology and an artistic piece about body clocks.

Read about the event here: www2.mrc-lmb.cam.ac.uk/lmb-highligh...

#LMBNews #CamFest @nsmyllie.bsky.social

04.04.2025 14:35 👍 4 🔁 2 💬 0 📌 1
LMB engagement team group photo

LMB engagement team group photo

LMB @cambridgefestival.bsky.social engagement team ready to go! Join us at CAST today 11-4 to explore the tiny scale of our research, play our mutant matching game & see @nsmyllie.bsky.social Sci-Art collaboration.
More details: www.festival.cam.ac.uk/events/molec...

22.03.2025 11:19 👍 8 🔁 1 💬 0 📌 0
Fluorescent microscopy image

Fluorescent microscopy image

Looking for something to do next weekend? Join us at
@cambridgefestival.bsky.social
We’ll be at CAST from 11AM-4PM on 22nd March
Discover how scientists unlock the mysteries of life by studying its constituent parts at vastly different scales

More details: www.festival.cam.ac.uk/events/molec...

17.03.2025 14:48 👍 4 🔁 4 💬 1 📌 1
A scientist looking under a microscope and an artist painting

A scientist looking under a microscope and an artist painting

We will also display the sci-art collaboration between the contemporary artist Laura Pearson-Clark and Nicola Smyllie @nsmyllie.bsky.social in the LMB's Neurobiology Division

17.03.2025 14:50 👍 0 🔁 2 💬 0 📌 0
Collage showing students in lab based work experience placements

Collage showing students in lab based work experience placements

📣 Last week to apply to our work experience placements
🧪🔬 Aimed at local Y12 students from state schools interested in a science career
🗓️ 28/07 – 1/08
Eligibility and selection criteria apply
Applications by 09/03

Info: www2.mrc-lmb.cam.ac.uk/students/wor...
#STEM #WorkExperience #BiologyCareers

03.03.2025 14:47 👍 0 🔁 1 💬 0 📌 1
Collage showing work experience students working in labs

Collage showing work experience students working in labs

📣 Applications are open for our work experience placements
🧪🔬 Aimed at local Y12 students from state schools interested in a science career

🗓️ 28/07 – 1/08
Eligibility and selection criteria apply
Applications by 09/03

www2.mrc-lmb.cam.ac.uk/students/wor...

#STEM #WorkExperience #BiologyCareers

13.02.2025 15:03 👍 1 🔁 4 💬 0 📌 0
Woman looking into a microscope, wearing blue, protective gloves and a white lab coat.

Woman looking into a microscope, wearing blue, protective gloves and a white lab coat.

This #WomenInScience Day, why not check out our 'Equity in Microscopy' Resource, which highlights women and other underrepresented people in #microscopy and #cytometry

A great resource for conference organisers!

Find out more and add to our database: www.rms.org.uk/community/eq...

11.02.2025 16:22 👍 14 🔁 6 💬 0 📌 0
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We work today and everyday for the right of every women and girls to be who they want to be. From REVERS-ED we are working to achieve this right from education, so educational inequalities won't be a barrier for any #internationaldayofwomenandgirlsinscience

11.02.2025 07:19 👍 8 🔁 7 💬 0 📌 0
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Happy International Day of Women and Girls in Science 🔬👩‍🔬 🎉

A big thank you to the fantastic scientists we get to work with every day as well as our enthusiastic event participants!

Let's continue to break down barriers and advance equality in science 💪

📸 Kinga Lubowiecka/ EMBL

11.02.2025 10:55 👍 17 🔁 9 💬 0 📌 1