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Traver Hart

@traver

Assoc Prof, MD Anderson. Functional genomics, CRISPR/Cas12a genetic interactions & synthetic lethality, history, politics, snark.

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Latest posts by Traver Hart @traver

hard to believe, innit

10.03.2026 15:59 ๐Ÿ‘ 0 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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โ™ฅ๏ธ from my lab โ™ฅ๏ธ

10.03.2026 15:26 ๐Ÿ‘ 2 ๐Ÿ” 0 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 0

Yeah, this is a big concern. It should be fundamentally challenging how we define a bioinformatics PhD, but disruption in availability of these tools in the future would be a huge problem.

08.03.2026 14:29 ๐Ÿ‘ 0 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0

We are also considering postdoc candidates with deep perspectives on transcription factor / chromatin biology, and would like to tackle such topics using high-throughput synthetic biology approaches.

08.03.2026 02:20 ๐Ÿ‘ 3 ๐Ÿ” 1 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0

shit.

bsky.app/profile/maks...

07.03.2026 00:58 ๐Ÿ‘ 0 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0

Imagine thinking you might have an air defense system, then having these lumbering senior citizens plodding uncontested through your airspace.

05.03.2026 16:39 ๐Ÿ‘ 0 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0

The US has dangled this carrot in front of the Kurds for literally a hundred years. Wilson was pilloried for naivete when he suggested that the post WWI empires be carved up on the basis of self determination.

05.03.2026 15:27 ๐Ÿ‘ 1 ๐Ÿ” 0 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 0

this has a nonzero chance of working out if IRI regime falls. zero otherwise.

28.02.2026 17:21 ๐Ÿ‘ 1 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0

first order effect: US air defense assets, especially high end SAMs, being used to defend middle east assets

second order: less avail for Ukraine. more effective Russian ballistic missile strikes. cruise missiles, drones not so much.

third order: China laughing as US stockpiles depleted.

28.02.2026 17:19 ๐Ÿ‘ 1 ๐Ÿ” 0 ๐Ÿ’ฌ 2 ๐Ÿ“Œ 0

Can confirm: this tool is very impressive. I'm fully bought into our AI-enhanced future. We will look back on the previous epoch as if we were living in black and white.

Unfortunately the planet will be metaphorically black and white, with nothing but sun-blasted stone and shrunken seas. Oh well.

15.02.2026 17:01 ๐Ÿ‘ 0 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0

Rosalind's companion piece to our genetic interactions manuscript. GRAPE, to analyze synthetic lethality screens, and Synulator, to generate simulated synthetic lethal gold standards because none exist today.

www.biorxiv.org/content/10.6...

10.02.2026 04:16 ๐Ÿ‘ 7 ๐Ÿ” 2 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 1

Rosalind's companion piece to our genetic interactions manuscript. GRAPE, to analyze synthetic lethality screens, and Synulator, to generate simulated synthetic lethal gold standards because none exist today.

www.biorxiv.org/content/10.6...

10.02.2026 04:16 ๐Ÿ‘ 7 ๐Ÿ” 2 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 1

"pending" has, in the past, been a good indicator that you're in the pipeline. obviously past performance is no longer a guarantee of future results, but hang in there.

21.01.2026 23:11 ๐Ÿ‘ 1 ๐Ÿ” 0 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 0

"victory"

21.01.2026 23:09 ๐Ÿ‘ 1 ๐Ÿ” 0 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 0

Playing Baldur's Gate 3 just so my computer will heat up my office.

18.01.2026 22:24 ๐Ÿ‘ 0 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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#FreeIran

10.01.2026 00:05 ๐Ÿ‘ 223 ๐Ÿ” 54 ๐Ÿ’ฌ 3 ๐Ÿ“Œ 1
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Not if I stop taking students.

07.01.2026 02:10 ๐Ÿ‘ 3 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0

One lesson that has become crystal clear over the last few years is how difficult, maybe impossible, it is to have meaningful discourse when both sides are the bad guy. Maybe it's always been this way.

04.01.2026 17:20 ๐Ÿ‘ 3 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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Functional modules predict cancer-relevant genetic interactions in mammalian cells Genetic interactions can reveal gene function and identify cancer-relevant synthetic lethals, but systematic mapping in human cells is constrained by inefficient reagents, vast combinatorial search sp...

Merry Christmas, genetic interaction nerds:

www.biorxiv.org/content/10.6...

21.12.2025 20:42 ๐Ÿ‘ 21 ๐Ÿ” 9 ๐Ÿ’ฌ 2 ๐Ÿ“Œ 0

Thanks for your hospitality! It was a wonderful trip to visit your group and to see Milan. Looking forward to our follow ups

21.11.2025 09:03 ๐Ÿ‘ 0 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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Delighted to host Traver Hart (MD Anderson Cancer Center), who delivered an engaging seminar on synthetic lethality at #HumanTechnopole. He showed how bridging #CRISPR and predictive modeling can advance design and interpretation of genetic interaction screens and inform new therapeutic strategies.

19.11.2025 16:58 ๐Ÿ‘ 7 ๐Ÿ” 3 ๐Ÿ’ฌ 2 ๐Ÿ“Œ 0

Adaptive behavior of predatory publisher "editors" - I was just invited to review one or more of a list of five articles, each submitted to different journals. I haven't seen that before.

09.10.2025 15:14 ๐Ÿ‘ 4 ๐Ÿ” 0 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 0

ouch that's absolutely worst case. what a disaster this has been.

09.09.2025 18:25 ๐Ÿ‘ 1 ๐Ÿ” 0 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 0

3%. Still waited 90 days after council meeting.

09.09.2025 18:07 ๐Ÿ‘ 1 ๐Ÿ” 0 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 0

NCI R01 NOA received. Long, long exhale.

09.09.2025 17:53 ๐Ÿ‘ 31 ๐Ÿ” 0 ๐Ÿ’ฌ 5 ๐Ÿ“Œ 1
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Life goals updated. Source: www.reddit.com/r/OldSchoolR...

05.09.2025 19:18 ๐Ÿ‘ 9 ๐Ÿ” 0 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 0

I can withdraw from social media now. I have learned everything worth learning.

05.09.2025 04:17 ๐Ÿ‘ 6 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0

Ruin a movie by making it about Gary

The Cook, The Thief, His Wife, and Gary

04.09.2025 12:37 ๐Ÿ‘ 5 ๐Ÿ” 0 ๐Ÿ’ฌ 2 ๐Ÿ“Œ 0

I could not agree more strongly with this. ๐Ÿ’ฏ

01.09.2025 21:23 ๐Ÿ‘ 1 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0

Ironically, it's not even in the Midwest.

01.09.2025 16:26 ๐Ÿ‘ 1 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0