Joel M(ultiplex)

For the night is dark and full of RNAses

How often do you or your colleagues actually reference the IFU of a given molecular test? I assume it's tied to utilization?

Screening, sorting, and the feedback cycles that imperil peer review The process of peer review is vital to contemporary science, but is also under enormous strain. This study uses mathematical models to dissect the threats to the long-term viability of peer review, su...

1. Kevin Gross and I have a new paper out today PLOS Biology.

We used economic models based around screening games and the market for unpaid labor to highlight a meltdown cycle threatening peer review.

(Dude suddenly stops pushing his broom across the floor of the Death Star)

Does this look like a big laser to anyone else

You: It can’t happen to me.

The state: we looked into this white guy we killed and we do feel a need to bring up these parking tickets

(1/7) Really pleased to have this published in @natcomms.nature.com

We looked at all public genomes encoding blaIMP (carbapenem #AMR ) 🦠🧫🧬💊. We show 5 IMP variants achieved global endemicity while 2 are regionally endemic.

www.nature.com/articles/s41...

#MicroSky #microbiology #IDSky #EpiSky 🧪

As I work on my syllabi for next semester, I find it really upsetting & depressing that Trump & RFK Jr destroyed so many valuable educational USAID & CDC public health resources that I used to ask my students to read (e.g. there used to be a superb USAID health policy implementation tool, now gone😔)

How credible is the claim "all"?
And what scope are we talking?

I was on an IRB at UW Madison for 6 years, and chair for 2. We would have run this proposal through a shredder, set fire to the detritus, mixed the ashes with concrete, and buried it in a salt mine. It's just outrageous.

Spurious correlation is literally just news now.

Clarity Initiative Clinical Literature Appraisal and Research education in InfecTious diseases

A group of ID clinical researchers passionate about clinical research and evidence appraisal has just launched the CLARITY initiative (clarityinitiative.org), which aims to improve the generation and interpretation of evidence in ID and Microbiology.

Loved your thanksgiving episode. Put a big smile on my face. Keep it up.

'Likely' first case of measles detected in Salt Lake County, but patient refuses to be tested Health officials believe they have detected the first case of measles in Salt Lake County, but they have so far been unable to verify it because the patient is not cooperating.

'Likely' first case of measles detected in Salt Lake County, but patient refuses to be tested https://www.fox13now.com/news/local-news/northern-utah/likely-first-case-of-measles-detected-in-salt-lake-county-but-patient-refusing-to-be-tested 

Listen I'm all for cataloging variation but the number of named oxa variants is out of control.

We have breaking news in Inside Medicine.

We had heard rumors of RIFs to CDC.

But this is the first visual confirmation that it has occurred tonight, and at high levels in the agency.

Here is what we know...and then some well-sourced rumors (but rumors, nonetheless, not confirmed) 🧵...

This plus the new health drop is a fun mix.

Big "I'm from Arizona" energy.

Maybe such a problem should be studied. and then maybe you should consult those studies.

And...crucially...stop listening to those who refuse to do the same.

By saying less and having the humility to acknowledge our limitations and ignorance. Something that is unfortunately antithetical so certain manifestations of "faith'

I understand and am with you

100% He has always been and will remain an asshole lawyer.

Interoperability between drastically different instrument measurements is bad maybe.

Lol that's just BioShock. Not even trying.

RFK Jr: “We're developing a universal vaccine at NIH which is a vaccine that addresses the entire phylum of viruses.” “It's a vaccine that mimics natural immunity and it is effective against any kind of mutation.” “We believe it's gonna be effective against not only coronaviruses but also flu.” “And it's gonna be a much safer and a much more effective vaccine.”

RFK has announced that he is developing a vaccine against all viruses. Yes, every single one. The whole, uh, "phylum"

Reporter: The FDA has a new AI tool that's intended to speed up drug approvals. But several FDA employees say the new AI helper is making up studies that do not exist. One FDA employee telling us, 'Anything that you don't have time to double check is unreliable. It hallucinates confidently'

AAP will continue to publish its own vaccine recommendations after CDC advisers sow distrust The CDC’s Advisory Committee on Immunization Practices plans to form a work group to review child and adolescent immunization schedules despite them undergoing constant review in real time.

The American Academy of Pediatricians bluntly telling us the current CDC can't be trusted, and of course they are absolutely correct

publications.aap.org/aapnews/news...

Absolute bloodbath at FDA, very bad

Came to recommend this book.

Following with keen interest.