Hatem Abouguendia

A glucocorticoid–FAS axis controls immune evasion during metastatic seeding - Nature Glucocorticoid receptor activation is a key driver of resistance of triple-negative breast cancer to both CD8+ T cells and natural killer cells during initial metastatic seeding.

www.nature.com/articles/s41...
The seeds of metastasis harness stress hormones to escape immune surveillance. So proud of this work! @harvardmed.bsky.social @danafarbernews.bsky.social @dfcibreastonc.bsky.social

Sensory neuron production of substance P and TAFA4 promotes disease tolerance during viral infection Neuroimmune interactions shape host responses to infection, but the molecular role of sensory neurons during viral infection remains unclear. Roger et al. show that HSV-1-activated sensory neurons pro...

#EveryCellIsAnImmuneCell! Ugolini, Roger &co show @cp-immunity.bsky.social that herpes simplex virus #HSV1 activates sensory #neurons that produce the neuropeptide SP to limit neutrophil influx, & TAFA4 that drives IL-10 by macrophages, overall fostering disease tolerance!

Aerobic glycolysis promotes NLRP3 inflammasome activation via NLRP3 lactylation Liu et al. reveal that lactate, an aerobic glycolysis product, promotes NLRP3 inflammasome activation and pyroptosis. NLRP3 is identified as a target of lactylation, and K24 and K565 have potential to...

#WeekendRead! #ImmunometabolismPower! #InflammasomePower! Liu, Yin &co show @cp-cellchembiol that lactate downstream of aerobic glycolysis is used to directly lactylates NLRP3 increasing ASC recruitment and inflammasome activation, which exacerbates lethality in sepsis! www.cell.com/cell-chemica...

SIRT4 regulates antiviral and autoimmune responses by promoting cGAS-mediated signaling pathways - EMBO Reports Cyclic guanosine monophosphate (GMP)-AMP synthase (cGAS) is a critical cytosolic DNA sensor, whose activity can be regulated by acetylation. Here, we show that nicotinamide adenine dinucleotide (NAD+)...

'SIRT4 interacts with cGAS and deacetylates cGAS directly, thereby promoting the binding of cGAS with cytosolic DNA and the generation of cGAMP. SIRT4 deficiency impairs DNA virus- or cytosolic DNA-triggered signaling.'
#Immunology #InnateImmunity

Nouvelle publication de l’unité : "Targeting Human Cytomegalovirus as a Novel Approach for Glioblastoma Treatment" - UMR 1092 RESINFIT Anti-Infectieux : supports moléculaires des résistances et innova... Un nouveau papier auquel Claire Gourin, Sébastien Hantz et Alexia Damour (membres de l’UMR Inserm 1092 RESINFIT) ont participé, est accessible en ligne. Il s’intitule « Targeting Human Cytomegalovirus...

📄 Une nouvelle publication de notre laboratoire @umr1092resinfit.bsky.social à découvrir ❗️

👥 T. Flores, E. Delpierre, G. Male, C. Gourin, S. Hantz, A. Damour, S. Hantz

✔️ "Targeting Human Cytomegalovirus as a Novel Approach for Glioblastoma Treatment" | 𝘗𝘢𝘵𝘩𝘰𝘨𝘦𝘯𝘴

➕ www.unilim.fr/resinfit/nou...

Wonderful story! Congratulations..

Two Postdoctoral Researchers at the Faculty of Medicine to Study the Initiation and Modulation of Immune Responses The immunology research group “Leukocyte Traffic and the Immune Response”, led by Professor Marko Salmi, invites applications for two fixed-term postdoctoral researcher positions at the [Faculty of Me...

We are hiring two postdoctoral researchers to study the Initiation and Modulation of Immune Responses! Check out at 👉 ats.talentadore.com/apply/kaksi-...

Professor Cecilia Soderberg-Naucler, one of MediCity’s group leaders, shares her insights in a recent interview with Aurora online.

Cecilia believes that cancer is something other than the genetic disease it is commonly thought to be. She thinks that the root cause of cancer lies in metabolism.

Optimization of the Blocking and Signal Preservation Protocol in High‐Parameter Flow Cytometry High quality input data is the key to successful interpretation of any scientific assay. In flow cytometry, fluorescently-conjugated antibodies allow us to simultaneously measure an incredible range ...

New #flowcytometery protocol drop from Oliver Burton.

This one is on optimising blocking while preserving signal, in particular how to overcome Fc interactions and dye-dye interactions, and preventing tandem break-down.

currentprotocols.onlinelibrary.wiley.com/doi/10.1002/...

What could cause the reactivation of Epstein–Barr virus in individuals with long COVID Published in Emerging Microbes & Infections (Vol. 14, No. 1, 2025)

What could cause the reactivation of Epstein–Barr virus in individuals with long COVID

-Direct virus infection?
-inflammatory mediators?
-metabolic signals?

www.tandfonline.com/...
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Denmark eliminates 25% book tax to combat declining reading skills Denmark is eliminating its 25% book tax after finding reading skills in steep decline. Culture Minister Engel-Schmidt: "The gift of reading is something we should give to younger generations."

Denmark eliminates 25% book tax to combat declining reading
boingboing.net/2025/08/22/d...

CGRP-related neuropeptide adrenomedullin 2 promotes tissue-protective ILC2 responses and limits intestinal inflammation - Nature Immunology Artis and colleagues show that enteric neurons produce CGRP-related ADM2 to promote intestinal tissue-protective functions in ILC2s.

#WeekendRead! #EveryCellIsAnImmuneCell! Artis @jazib.bsky.social &co show @natimmunol.nature.com that enteric neurons produce the neuropeptide ADM2 which acts directly on ILC2s limiting intestinal damage/#IBDs via amphiregulin production!
www.nature.com/articles/s41...

Imidazole propionate is a driver and therapeutic target in atherosclerosis - Nature Imidazole propionate produced by gut microbiota is associated with atherosclerosis in mouse models and in humans, and causes the development of atherosclerosis through activation of the imidazoline-1 ...

A beautiful study highlighting the power of untargeted metabolomics:

Imidazole propionate is a driver and therapeutic target in atherosclerosis www.nature.com/articles/s41...

Aluminum-Adsorbed Vaccines and Chronic Diseases in Childhood: A Nationwide Cohort Study

24 years .... no effect. The aluminium in vaccines has NO negative health effects.

www.acpjournals.org/...
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Sometime, you don’t even need seahorse to know your hypothesis on metabolic rewiring is working..
Warburg effect in action!

CMV co-evolved with human. It is a master regulator of immunity and knows about our biology more than we do.

High-performance genetically-encoded green and red fluorescent biosensors for pyruvate Pyruvate is the end-product of glycolysis and a central metabolite involved in many biochemical pathways. However, a lack of high-performance (i.e., Δ F / F > 10) single fluorescent protein (FP)-base...

New tools! GreenPy and ApplePy are fluorescent biosensors for pyruvate with huge responses (20–40x in vitro) and a range of affinities (10s of μM to mM). These should be game changers for imaging of metabolism! Great work by Shosei Imai @sikmys.bsky.social and team 👏. www.biorxiv.org/content/10.1...

Mitochondria Summer School

Join this event for PhD students and postdocs in the amazing wilderness of Northern Finland! Reg. dl Thu 10th Apr. Spa hotel Rokua with plenty of saunas and pools and other fun. 😎 Network and learn about mitochondria! @mitoworld.bsky.social @richterlab.bsky.social @ki.se @cecad.bsky.social

We are Hiring! Join our multi-disciplinary team as a Postdoc or a Bioinformatician in B-cell Immunology to lead exciting projects on human immunology funded by the Gates Foundation and the NIH (Position fully funded and not dependent on future grants).

We are #Hiring! Please share!
#ImmunoSky 🧪
Join our multi-disciplinary B-cell team @Emory/ATL to lead exciting projects on human immunology funded by the Gates Foundation and the NIH (Position fully funded and not dependent on future grants).

ghosnlab.science/join-us
#BYourCell

Oxidation of retromer complex controls mitochondrial translation - Nature Systematic base-editing and computational screens identify specific cysteine residues on VPS35 in the retromer complex as key sensors that decrease mitochondrial translation in response to reactive ox...

I’m excited to share the latest work from our lab, led by a group of three amazing scientists: Junbing Zhang, Yousuf Ali and Harrison Chong, who describe @nature the discovery of a ROS sensor, VPS35, which links cytosolic H2O2 levels to regulation of mitochondrial translation and

Excited to share our last study. Huge congrats to Sarah Monard, Arnaud Métais, @gclugo.bsky.social, @chrisverollet.bsky.social and all colleagues!
We have found a mysterious cell type inside TB lung lesions that seems neuron-like but isn't quite a nerve cell.
Let's dive in👇

shorturl.at/x4Sb5

NIH Grants Fueled $95 Billion In FY 2024 Economic Activity, Finds New Report National Institutes of Health grants generated almost $95 billion in economic activity nationwide in FY 2024 according to a new report by United for Medical Research.

New report shows that NIH grants fueled $95 billion in economic activity and 407,782 jobs in 2024.

That's not to mention the countless lives that biomedical research has saved.

Show me a better investment than that.
www.forbes.com/sites/michae...

Thank you 🙏

Any recommendations for resources to learn phosphoproteomics analysis?

I ordered an antibody 2 months and half ago .. Today I receive it, just one day before I start my holiday 🌚

Isn’t it disappointing when you see an article that has an experiment you always wanted to do but never did?! Or is it exciting that your hypothesis came true?

Cancer cells ‘poison’ the immune system with tainted mitochondria Immune cells lose their cancer-fighting prowess after taking tumours’ organelles on board.

Really interesting paper 🧪 🤩

Immune evasion through mitochondrial transfer 😮

Ikeda et al find that #mitochondria from cancer cells can #transfer over to T cells - altering their #metabolism & reducing antitumour immunity

www.nature.com/articles/s41...

www.nature.com/articles/d41...

@nature.com

An hour a week, if well planned and strategically directed, lets you #explore, discard and engage with multiple career options, so you can pick the #career you are most interested in. Early markers let you sell yourself as purposeful, even when you hadn't decided on a #goal. Good luck!🤞4/4

📣 This year's #ENII @efis-immunology.bsky.social @eurjimmunol.bsky.social summer school on Advanced Immunology is happening in Alghero, IT - directly reachable via Brussels airport.

Early registration is open & more information can be found here:
www.enii.org

#ImmunoSky

Canids as pollinators? Nectar foraging by Ethiopian wolves may contribute to the pollination of Kniphofia foliosa Click on the article title to read more.

Huh. There are flowers in Ethiopia that native nectar-foraging wolves pollinate! 🦊😋🌻🍊
🧪

"Canids as pollinators? Nectar foraging by Ethiopian wolves may contribute to the pollination of Kniphofia foliosa"
by Lai et al. (2024, Ecology)
esajournals.onlinelibrary.wiley.com/doi/10.1002/...