Flyer for symposium: https://ctrlepiedit.sciencesconf.org/
Very excited to announce the FIRST symposium on epigenome editing! These tools are becoming widely used in mol bio, ag & therapy. It's time to bring leaders together to discuss this rapidly growing and exciting field. And why not in Paris! Please register & share! (1/2) ctrlepiedit.sciencesconf.org
I still put Bugonia in his top 3. I didn't like Marty Supreme at all, it's Uncut Gems but instead of dealing around with diamonds it deals with a dog??
Too low! The Stone/Plemons combo is too good
Bugonia #5 really Max?????????
Also I highly recommend Train Dreams
1/ 🧵 In our new paper, we show that JARID2 and PALI1 mimic H3K27me3 to antagonise PRC2. www.cell.com/molecular-ce...
Fantastic collaboration w/ @dbikard.bsky.social @audeber.bsky.social @rayanchikhi.bsky.social labs led by @jmouradesousa.bsky.social : We assessed the rates of variation of anti-phage systems in P4-like satellites and P2 helper phages. Quick conclusion: Huge variation! We focus on 4 key questions/5
🧵 Thread: What happens when transcription isn’t properly shut off during mitosis? Our new preprint explores just that 👇
www.biorxiv.org/content/10.6...
theonion.com/scientists-p...
🚨Preprint alert🚨 How does chromatin “architecture” form at CTCF sites? Our new preprint with @voslab.org and @andersshansen.bsky.social shows CTCF dimerization promotes nucleosome oligomerization on chromatin. tinyurl.com/CTCF-nucleos...
New paper from my lab out in NAR. We found that young L1 elements are controlled by SETDB1 and H3K9me3 in human neural progenitor cells via a mechanism independent of HUSH and TRIM28/KZNFs.
academic.oup.com/nar/article/...
coffee karyotype
Mus pahari takes center stage! This looks fantastic and is going straight to the top of my to-read pile
New preprint from the lab! We dig into the regulatory roles of TEs in the mouse placenta, with some surprising findings. Led by the awesome @smamante.bsky.social. Particular kudos to him for navigating the many twists and turns of the project.
Very cool. I would have guessed that they’d encode an EZH2 activity promoting gene, not inhibiting, in order to get K27 methylated and hide from the host!
🔔 New paper alert 🔔 www.nature.com/articles/s41...
Some regions in the genome replicate early and some late, but the why and how remain poorly understood. DNA replication and 3D genome organization appear linked, raising the question if one may regulate the other? (1/n)
So cool!!
This is fantastic congrats to all!
Any idea why there are fewer temporal TF changes at the mid neuroblast stage? Does it mean it's the most conserved stage?
Read in Nature: nature.com/articles/s41586-025-09899-8
Stress controls epigenetic inheritance!
A histone ubiquitylation-based regulatory hub links stress/environmental signaling to heterochromatin self-propagation and epigenetic inheritance-reshaping how we think about development, drug resistance, and cancer
👉 nature.com/articles/s41586-025-09899-8
For anybody with an e-reader, I highly recommend these free, standardised e-books
standardebooks.org/blog/public-...
Happy to begin the year with the publication of a Journal Club article - Programmed ‘DNA splicing’ removes transposons from genes.
rdcu.be/eXBym
Hot from the press: Using single-cell chromatin accessibility and gene expression across ~300,000 cells, we show that prostate cancer dissemination involves phenotypic plasticity over clonal selection, with malignant cells converging toward an inflammatory-like state during lymph node spread.
@pravrutharaman.bsky.social got super intrigued about EZHIP/CATACOMB, previously identified as a histone H3K27M mimic of PRC2. You can read about her efforts here: www.biorxiv.org/content/10.6... We hope these analyses will help spur more analyses in this very cool gene! 1/
It's always exciting when the latest edition of JASPAR comes out. Great leadership by @amathelier.bsky.social and pleased to welcome @anshulkundaje.bsky.social to the journey. #Jaspar2026
academic.oup.com/nar/advance-...
Did you venture out beyond Zdbf2??
1/ I’m very excited to share my postdoc work with @kseskv.bsky.social, in collaboration with @oligriffith.bsky.social. We explore embryonic DNA methylation reprogramming in the fat-tailed dunnart, an Australian marsupial 🦘🌏 www.biorxiv.org/content/10.1...
Great now I'm going to have nightmares in Paramecium
A black and yellow background. There is a credit to the CBC for a headline that reads: “Canada loses measles elimination status. Updated 5 minutes ago. Public Health Agency of Canada says outbreak has persisted for over 12 months.” The message below reads: “This was all preventable. The MMRV vaccine remains very safe and effective. And yet, medical misinformation makes it increasingly hard for Canadians to make good decisions to protect their families.” #ScienceUpFirst
Canada has lost its measles elimination status after more than 25 years, despite evidence of efficacy and safety for the vaccines. 👇
scienceupfirst.com/public-healt...
#ScienceUpFirst
🧵1/2
Polycomb Repressive Complexes 1 and 2 are recruited independently to pericentromeric heterochromatin in response to hypomethylation in mouse embryonic stem cells https://www.biorxiv.org/content/10.1101/2025.11.14.688451v1
