Anupam Patgiri

L-Lactate reprograms tumor-associated macrophages to drive pancreatic cancer progression via BCL3 lactylation

www.biorxiv.org/content/10.6...

a group of women 's hands making a heart shape with the words women 's day below it ALT: a group of women 's hands making a heart shape with the words women 's day below it

Most recent advances in small molecule analysis summarized here

biomed.news/bims-metlip/...

biomed.news/bims-metlip/...

A collaboration with @biomednews.bsky.social

Vitamin B2 and B3 nutrigenomics reveals a therapy for NAXD disease A nutrigenomics framework identifies genetic diseases amenable to vitamin B2 and B3 therapies. This approach nominates vitamin B3 as a therapy for NAXD deficiency, a lethal neurodevelopmental disorder...

Last 2 weeks of literature on #Mitochondria in #Health & #Disease! 🤍 💚
biomed.news/bims-mitdis/...
biomed.news/bims-mitdis/...

@biomednews.bsky.social @mitoscientist.bsky.social @gavinmcstay.bsky.social

Vit B2 and B3 nutrigenomics reveals a therapy for NAXD disease
www.cell.com/cell/fulltex...

Good Sunday, all! Don't miss this weekly curated summary of papers in #cancermetabolism and #mitochondrialbiology, it contains wonderful discoveries. Check it here: biomed.news/bims-camemi/... Biomed News #keepreading

"You're only as free as your attention is."-Sam Harris

Efficient amyloid-β degradation in Alzheimer’s disease using SPYTACs SPYTAC is a synthetic peptide-programmed targeted protein degradation platform harnessing LRP1 to drive lysosomal degradation of extracellular amyloid-β in the brain and periphery. In 5×FAD mice, SPYT...

Efficient amyloid-β degradation in Alzheimer’s disease using SPYTACs

www.cell.com/cell/fulltex...

Are obesity drugs causing a severe complication? What the science says Nature - The United Kingdom and Brazil have issued warnings about a possible link between GLP-1 weight-loss drugs and pancreatic inflammation, but the connection is murky.

A rare and potentially fatal illness that might be linked to GLP-1 drugs is now causing alarm

go.nature.com/46to3j2

‘An AlphaFold 4’ – scientists marvel at DeepMind drug spin-off’s exclusive new AI Isomorphic Lab’s proprietary drug-discovery model is a major advance, but scientists developing open-source tools are left guessing how to achieve similar results.

‘An AlphaFold 4’ – scientists marvel at DeepMind drug spin-off’s exclusive new AI
www.nature.com/articles/d41...

Why Study Rare Disease? JAX's Nadia Rosenthal Talks "Rare to Common" Enjoy the videos and music you love, upload original content, and share it all with friends, family, and the world on YouTube.

For Nadia Rosenthal, scientific director at JAX, the lesson is clear: “Rare diseases often give us a clear window into the fundamental workings of biology, and what we see through that window can tell us about much more widespread conditions.” 🧪 🧬 #RareDiseaseDay https://go.jax.org/nadia-yt-social

Good Sunday, all. There is a wonderful curated selection of papers in #cancermetabolism and #mitochondrialbiology here: biomed.news/bims-camemi/... @biomednews.bsky.social #keepreading

The real truth, that dare not speak itself, is that no one is in control. Absolutely no one.

Terence McKenna

a man is sitting on a couch and pointing at something with the word look written on the bottom ALT: a man is sitting on a couch and pointing at something with the word look written on the bottom

#Autophagy and #mTOR papers from last week, don’t miss this selection brought by @biomednews.bsky.social engine!

biomed.news/bims-auttor/...

A Scalable Design for Proximity-Inducing Molecules

www.biorxiv.org/content/10.6...

Decoding cancer across scales with metabolomics - Nature Reviews Cancer In this Review, Rowles and Patti present metabolomics workflows to study cancer across scales. They explore the nutrient demands of cancer cells and how those needs can be fulfilled through metabolic ...

Decoding cancer across scales with metabolomics www.nature.com/articles/s41...

The Key to Longevity May Be Found Inside Our Cells

The Key to Longevity May Be Found Inside Our Cells
Why health influencers are obsessed with mitochondria.
www.nytimes.com/2026/02/19/w...

Design and optimization of amyloid-responsive chimeric antigen receptors (CARs)

One of the most-viewed PNAS articles in the last week is “Engineering chimeric antigen receptor CD4 T cells for Alzheimer’s disease.” Explore the article here: https://ow.ly/jswG50Yi6q0

For more trending articles, visit https://ow.ly/IIK050Yi6q1.

A CRISPR-based mitochondrial gene therapy tool derived by engineering guide RNAs Wang et al. systematically analyzed mitochondria-localized lncRNAs to reveal that RBP-motif recognition drives RNA mitochondrial translocation, leading to the engineering of an RNA mitochondrial targe...

A CRISPR-based mitochondrial gene therapy tool derived by engineering guide RNAs

www.cell.com/cell-reports...

We are hiring a postdoc! The group has a funded opening to join our amazing team on the NCI's Frederick, MD campus.

This is an opportunity to train in cutting-edge chemical & RNA biology methods with a supportive, tight-knit group.

Link to posting below. Please share!

jobrxiv.org/job/national...

Good morning, all! Here is a beautiful selection of papers in #cancermetabolism and #mitochondrialbiology. Don't miss it! biomed.news/bims-camemi/... @biomednews.bsky.social #keepreading

"For everything you do, there will be a last time that you do it."-William B. Irvine

Benchmarking second-generation methods for cell-type deconvolution of transcriptomic data https://www.biorxiv.org/content/10.1101/2024.06.10.598226v1 🧬🖥️🧪
omnideconv #Rstats pkg https://github.com/omnideconv/deconvBench
Nextflow pipeline https://github.com/omnideconv/deconvBench

Inflammation, cell and mitochondria damage biomarkers, and links to cognitive dysfunction in #LongCovid relative to recovered controls
www.nature.com/articles/s41...

MetaboList – January 2026 Glucose metabolism Glucose deprivation drives LIF-dependent lung cancer Fedra Luciano-Mateo, Joaquim Moreno-Caceres, Miguel Hernández-Madrigal, Franziska Püschel, Lidia Collado-Rodriguez, Francesca…

Cancer metabolism, papers from January 2026.
Glycolysis, starvation, nutrient sensing, hypoxia, amino acids, cachexia, diet, lipids, cancer immune metabolism...
MetaboList
metabolist.wordpress.com/2026/02/09/m...

Mitochondrial superoxide regulates nuclear envelope integrity and ageing via redox-mediated lipid metabolism - Nature Metabolism Mitochondrial superoxide production is shown to preserve nuclear envelope integrity by controlling lipid peroxidation, with impact on nuclear and organismal ageing in C. elegans.

A new collection of papers on #Mitochondria in #Health and #Disease! #MitochondrialDisease 📚
biomed.news/bims-mitdis/...

@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social
Mt superoxide regulates nuclear integrity and ageing via lipid metab

www.nature.com/articles/s42...

Good Sunday, all. Here is your weekly selection of papers in #cancermetabolism and #mitochondrialbiology. So many exciting findings!! biomed.news/bims-camemi/... @biomednews.bsky.social

Biomed News #keepreading

"I am a part of all that I have met."-Alfred Tennyson

Not something you see in textbooks very often: tripolar mitosis.

This #WorldCancerDay we're highlighting work from Rockefeller's Kivanc Birsoy. In this Q&A, he shares why he's hopeful that targeting cancer cells' nutrients will yield a new, effective approach to fighting cancer: https://bit.ly/4qRBIse

Both chambers of Congress have now passed the FY26 minibus with NIH provisions. The President will sign.

(1) $48.7 billion for NIH
(2) Full IDC recovery
(3) No more multi-year funding
(4) No NIH reorganization, maintaining the current IC structure.

Thank you!

Christian, could you please add the biomed.news link for the papers?

Good Sunday, mitolovers. Here is the weekly curated issue of papers in #cancermetabolism and #mitochondrialbiology, with truly remarkable papers: lnkd.in/e7HDuVuU @biomednews.bsky.social #keepreading

"Attention is the rarest and purest form of generosity."-Simone Weil

A new collection of papers from #week5 on Mitochondria in Health & Disease! #MitochondrialDisease
biomed.news/bims-mitdis/...

@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social @mitoscientists.bsky.social

Among highlights
www.nature.com/articles/s41...

Large language model guides exploration of the dark metabolome DeepMet may help uncover previously uncharacterized metabolites

Large language model guides exploration of the dark metabolome

cen.acs.org/analytical-c...