In a new study in Science Translational Medicine, utilizes epigenomic mapping with EpiCypher's CUTANA™ CUT&RUN revealing a new combo therapy for aggressive pediatric brain tumors.
🔗Read more: https://www.science.org/doi/10.1126/scitranslmed.adr1557
#Epigenetics #ChromatinBiology #CancerTherapeutics
We are excited to share our latest multiomic data at Keystone Symposia in Banff 🏔️
March 11 | 7:30 PM | # 2016
Multiomic Long-Read Sequencing to Resolve Chromatin States Driving Outcomes in Genomic Engineering
👉 Download here: https://explore.epicypher.com/posters/keystone26/lrs-genomic-engineering
⚡This Wednesday! 🥁We've got two exciting chromatin talks coming up from @almassalha.bsky.social and @carmeloferrai.bsky.social
🐣If you haven't registered for the series, please register and join us: us06web.zoom.us/webinar/regi...
When it comes to high-resolution genomic mapping with low input requirements, CUT&RUN remains a trusted gold standard. To support your research, we are offering a limited-time 15% discount on our popular CUTANA™ CUT&RUN Kit + Library Prep Kit bundle.
Learn more here: https://ow.ly/7TZ350YpH2e
Fiber-seq combines multiple measurements into a single long-read assay, capturing chromatin accessibility and DNA methylation together on individual DNA molecules. Our Fiber-seq 101 blog walks through how the assay works and what it enables: https://www.epicypher.com/resources/blog/fiber-seq-101/
We’re looking forward to the 2nd Genome Regulation Through RNA Conference!
Michael-Christopher Keogh, PhD, will share insights on standards-driven genomic mapping approaches to measure acute transcriptional responses.
🗓 March 5 | 12:00 PM
Who else is attending?
New Webinar Page! 👨🔬✨
Browse our on-demand webinars to see how experts use advanced technologies—like long-read assays and optimized CUT&RUN/CUT&Tag — to drive discoveries in cancer, immunology, drug development, and more.
Start exploring today👉 https://www.epicypher.com/genomics-webinars/
We're headed to the Keystone Symposia in Geneva 🇨🇭
Wed 3/4 at 10:30 AM UTC+1
Bryan Venters, Senior Director of Genomic Technologies, will speak on Fiber-seq, a long-read, single-molecule assay that profiles chromatin accessibility, DNA methylation, and genetic variation in one experiment.
CUT&RUN or CUT&Tag data in hand, now what?
In our new blog, we highlight CUTANA™ Cloud, a streamlined analysis platform built to help biologists interpret chromatin profiling datasets without getting stuck in complex pipelines.
Read more:
https://ow.ly/CjMe50YmoQO
🔥 Advancing your DNA methylation research? 🧬
CUTANA™ meCUT&RUN enriches methylated DNA for efficient genome-wide analysis.
Multiomic CUT&RUN co-profiles DNA methylation and chromatin proteins from the same sample.
Learn More 👉 https://www.epicypher.com/products/dna-methylation-sequencing-assays/
Next week on Fragile Nucleosome:
🧬 Pavan Choppakatla from the Levine lab will share his work on long-distance enhancer-promoter search
🧬 @moorejille.bsky.social will tell us about millions of enhancers in the registry of candidate CREs
Register here and join us!: us06web.zoom.us/webinar/regi...
The replay is live 🎥
Michael-Christopher Keogh, PhD, kicks off the 2026 Fragile Nucleosome seminar series with a deep dive into the histone PTM landscape of the mouse immune system.
If you missed it, now’s your chance to catch up and join the discussion.
Watch here: https://youtu.be/JxlLsmAa2jo
New co-authored study in Genes & Development 📄
Patriotis et al. show that the conserved EZH2 SANT1-binding domain regulates PRC2 activity & genome-wide H3K27 methylation.
https://doi.org/10.1101/gad.353070.125
How do you study chromatin, DNA methylation, and genetic variation on the same DNA molecule? 🧬 Emily Madden, PhD will walk through Fiber-seq, a long-read, single-molecule epigenomic approach enabling genome-wide discovery with locus-level context.
📅 Feb 18 | ⏰ 11:00–11:30 am
This Valentine’s Day, don’t go it alone. 💕
Fiber-seq custom services pair you with an EpiCypher expert for hands-on assay setup, best practices, and bioinformatics support—so you get high-quality data with confidence.
👉 https://www.epicypher.com/services/cutana-fiber-seq-assay-services/
We recently welcomed Dr. Steve Henikoff to EpiCypher for a seminar on “Epigenomic profiling for personalized medicine.”
From chromatin mapping advances to thoughtful team discussions, it was an energizing visit.
Always grateful to learn alongside leaders in #Epigenetics 🔬
It’s International Day of Women and Girls in Science. 🔬
We’re celebrating the women whose research, mentorship, and leadership continue to move science forward and open doors for the next generation.
#WomenInScience
New paper out in ACS Central Science from EpiCypher + the Kelleher lab: “Direct Readout of Multivalent Chromatin Reader-Nucleosome Interactions by Nuc-MS” (Lee et al., 2026). Love seeing intact nucleosomes used to capture multivalent reader behavior, plus the role of dNucs™ and Captify™🧬
Using EpiCypher reagents for DIY CUT&RUN or CUT&Tag? 🧪
Our updated DIY protocols are live with clearer handling guidance, optimized bead ratios, and the CUTANA™ Wash Buffer Enhancer Set to help reduce variability, especially for nuclei inputs. Take a look and tell us how it works in your lab.
Recently, our CSO Michael-Christopher Keogh, PhD shared a talk at New England Biolabs on multi-omic views of chromatin function.
Thanks to NEB for hosting and for the ongoing scientific collaboration. 🧬🔬
#Epigenetics #Chromatin
We've got two exciting chromatin talks coming up on Wednesday next week:
@epijenatics.bsky.social from @jbuenrostro.bsky.social's lab and @ambystoma22.bsky.social!
register and join us: us06web.zoom.us/webinar/regi...
On #WorldCancerDay, we reflect on the impact of cancer and the progress we’re making together.
EpiCypher is proud to support labs decoding chromatin dynamics in cancer—because understanding epigenetics changes the game. 🧬 Let’s keep pushing forward.
Punxsutawney Phil says winter’s sticking around ❄
But so are we—in the lab, at the bench, decoding chromatin one nucleosome at a time. What’s your go-to winter epigenetics workflow? #Epigenetics
Attention: Researchers in genomics, epigenetics, and single-cell biology! Watch our on-demand webinar to explore how Paired-Damage-seq integrates DNA damage mapping with transcriptomics to reveal cell-type-specific genome instability.
Watch now 👉 https://ow.ly/kAUg50Y4Seu
Last Chance To Register!
Learn how Paired-Damage-seq links DNA damage with transcriptomics in our webinar with Epigenome Technologies.
Register Here: 👉 https://app.livestorm.co/epicypher/single-cell-dna-damage-analysis-reveals-selective-genome-vulnerability
See EpiCypher at the Festival of Genomics & Biodata (London), Jan 28 - 29, 2026. Poster: “Fiber-seq connects genetic variation to epigenomic function on single DNA molecules”. Not attending?
Download the poster: https://explore.epicypher.com/posters/LRS-emily/FOG2026 #Epigenomics #Genomics
EpiCypher’s at #KeystoneSymposia this week!
🧬 Poster #2001: Fiber-seq connects genetic variation to epigenomic function on single DNA molecules
📍 Jan 28, 7:30 PM ET | Cary, NC
Missed it in person? Download the full poster:
https://explore.epicypher.com/posters/Keystone-Jan2026/fiber-seq
🥁 #FragileNucleosome is back on Jan 28! We are very excited to host @au-ho-yu.bsky.social and @gcloner.bsky.social as our first speakers of 2026!
📋Please don't forget to register for our 2026 seminar series: us06web.zoom.us/webinar/regi...
How can you profile chromatin accessibility, DNA methylation, and protein footprints in a single assay?
🔗 Read more: https://www.epicypher.com/resources/blog/fiber-seq-101/
#Epigenomics #Chromatin #ATACseq #Multiomics #Fiberseq #EpiCypher
Running into issues with CUT&RUN, CUT&Tag, or Fiber-seq? 🧬 You’re not alone. Our Tech Support Center has in-depth guides, from antibody selection to CUTANA™ Cloud analysis.
Explore the help hub 👉 support.epicypher.com
#Epigenetics #ChromatinMapping
