Hua Wang UIUC

We further showed that RENBP inhibition can significantly improve the metabolic labeling efficiency of azido-mannosamine in APCs both in vitro and in vivo. Our study provides a facile approach to improving chemical tagging of APCs for the development of APC-targeted immunotherapies.

We found that murine and human antigen presenting cells (APCs) such as dendritic cells, macrophages, and B cells tend to overexpress RENBP. This could partially explain why azido-mannosamine exhibits low labeling efficiency in APCs.

Happy to share our new research article entitled “RENBP inhibition amplifies metabolic glycan labeling efficiency of antigen-presenting cells in vitro and in vivo”. cancer.illinois.edu/hua-wang-unv...

Happy to share that I have been promoted to Associate Professor with tenure. Grateful for the tremendous support from my students, collaborators, colleagues, and friends in this journey! My lab will keep the good work going and try our best to contribute to the research community.

We show the promise of EV hydrogel for depot cancer vaccine, but can certainly envision diverse applications of this technology in the context of different diseases.

Injectable extracellular vesicle hydrogels with tunable viscoelasticity for depot vaccine - Nature Communications Extracellular vesicles (EVs) play a critical role in mediating intercellular communication, but the poor tissue retention of EVs has limited the efficacy of EV-based therapies. Here, the authors repor...

Happy to share our recent work on Extracellular vesicle hydrogel. Now hopefully researchers in the EV community do not have to worry about the minimal loading efficiency of EV into a pre-formed hydrogel. Instead, one can use EV itself as a building block for hydrogels.
www.nature.com/articles/s41...

Received this beautiful glass brain from Sontag. Thank you for this thoughtful design and the amazing retreat! @Sontag Foundation

Brain cancer treatment research backed via prestigious grant Brain cancer treatment research backed via prestigious grant

Excited and humbled to receive the 2024 Sontag Distinguished Scientist Award. My group and I are grateful for the tremendous support from the Sontag Foundation and @UIUC MatSE and CCIL! We will continue our quest for therapeutic cancer vaccines and immunotherapies!
matse.illinois.edu/news/72039

Cytokine-overexpressing dendritic cells for cancer immunotherapy - Experimental & Molecular Medicine Cancer immunotherapy has transformed cancer treatment, particularly with immune checkpoint blockades and CAR T cell therapy. However, cancer vaccines have been less effective. Researchers investigated...

Happy to share our recent Review article titled "Cytokine-overexpressing dendritic cells for cancer immunotherapy". Hope it is of interest to the broad audience.
www.nature.com/articles/s12...

Cancer cells impair monocyte-mediated T cell stimulation to evade immunity - Nature Inflammatory monocytes are identified as important players in T cell restimulation in the tumour microenvironment.

Sorry for that! Please find it here. Thanks for reading. www.nature.com/articles/s41...

Nice work! Congrats!

The Living Materials & Tissue Engineering community continues to grow on Bluesky. So great to see more colleagues over here AND to met new/rising stars in our community.

Lets keep growing & sharing our work.

And let me know others to add including self-nominations!

go.bsky.app/AeG8FWr

Next-generation combination approaches for immune checkpoint therapy - Nature Immunology In this Review, Sharma and colleagues describe the current landscape of combination therapies and discuss requirements for the development of effective combination strategies.

www.nature.com/articles/s41...

Sharing our latest review article to highlight the importance of appropriately developing combination strategies for immune checkpoint therapy. Grateful for working with 3 brilliant scientists: Sangeeta Goswami, Kristen Pauken & Linghua Wang

Starter packs BIOLOGY General Science community https://go.bsky.app/HVYAMEA Research Institutions in Life Sciences https://go.bsky.app/LxXpcvJ LGBTQIA+ in STEM https://go.bsky.app/BFc4wgf LGBTQIA+ in STEM 2 h...

Thank you so much to whoever put this very comprehensive list of #science Bsky starter packs together. This is just amazing: docs.google.com/document/d/1...

Thanks Matt for initiating this pack. Can you help add me? Thanks.

Thank you Ute! I guess it is too late, but please help add me if there is still a spot. Thanks!

Here's a great opportunity for undergrads to apply for a summer internship at the NIH! Applications are due Jan. 8th. Follow link for more details and to apply:
www.nibib.nih.gov/labs-at-nibi...

🎨 In case anyone need…

The NIH BioArt Source is an awesome library of *free* professionally drawn illustrations for scientific presentations or figures. Downloadable in HD. Thank you NIH for this invaluable tool 🙏!

Check it out 👇
bioart.niaid.nih.gov

PD-1 and CD73 on naive CD4+ T cells synergistically limit responses to self
www.nature.com/articles/s41...

Can you add me, Monica? Thanks!

Can you add me, Daniel? Thanks!

Thanks Natalie. Can you help add me?

Hi John, can you help add me? Thanks!

Thanks for initiating this pack. Can you help add me? Thanks!

Hi Jon, thanks for initiating the starter pack. Can you help add me to the cancer immunotherapy one? Thanks!

Hi Santiago, thanks for initiating the starter pack! Can you add me to the Biomaterials and Immunoengineering ones? Thanks!

Thanks for initiating the starter pack! Can you add me as well? Thanks!

Had a lovely visit at Rice Materials Science and NanoEngineering. Thanks for being a great host @ctringides.bsky.social Awesome faculty, students, and research environment! Also finally met my collaborators at MD Anderson in person, and got to know many new friends there.

Thanks for the warm welcome, Brendan! New to Bluesky. Great to connect here!