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Melanie McReynolds

@drohsopretty

Who needs social media? I have followers in real life. Assistant Professor and HHMI Hanna Gray Faculty Fellow at Penn State. Aging, Metabolism, and Faith-Based Science. Mississippi born and raised.

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18.11.2024
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Latest posts by Melanie McReynolds @drohsopretty

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A metabolic safety valve for reductive stress - Nature Metabolism The glycerol-3-phosphate shuttle links redox balance to lipid synthesis, making the relief of reductive stress costly. Pan et al. rewire this circuit with a bifunctional enzyme that uncouples NAD⁺ reg...

Excited to share our lab’s latest contribution where we highlight a new development for a bifunctional enzyme that mitigates redox imbalance and lipotoxicity for the potential use as a treatment for metabolic disorders.

www.nature.com/articles/s42...

16.02.2026 12:34 👍 1 🔁 0 💬 0 📌 0
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Huge congratulations to Dr. Abrar Alsaadi on successfully defending her dissertation!

My first PhD graduate—an incredible milestone for her, for me, and for the McReynolds Lab. So proud of the scientist and leader she has become.
Onwards and upwards.!

10.02.2026 13:06 👍 2 🔁 0 💬 0 📌 0
Melanie McReynolds and her former Ph.D. mentor, Wendy Hanna–Rose, examine a specimen using a light microscope in McReynolds’s lab at Penn State in 2025.

Melanie McReynolds and her former Ph.D. mentor, Wendy Hanna–Rose, examine a specimen using a light microscope in McReynolds’s lab at Penn State in 2025.

Driven by an experience familiar to many — watching parents age — HHMI Hanna Gray Fellow Melanie McReynolds wants to answer a fundamental question: How can we age healthier? The key may lie in better understanding NAD+ & how its levels decline as we grow older. Via @asbmb.bsky.social: bit.ly/45tDuHB

18.01.2026 16:26 👍 12 🔁 5 💬 0 📌 0
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Huge congratulations to our ABRCMS 2025 award winners! 🏆✨

• Isaiah Diggs – Outstanding Poster Presentation
• Lily Williams – Outstanding Poster Presentation

So proud of the excellence, dedication, and growth these two have shown since joining my lab as freshmen. They shined on the national stage!

25.11.2025 17:31 👍 54 🔁 7 💬 1 📌 0
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So proud — like the soccer mom type of proud— of my senior undergrad Isaiah Diggs for winning a poster award at SACNAS!

01.11.2025 21:02 👍 11 🔁 0 💬 0 📌 0
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Here are our undergrad students in BMB 488 having a deep dive discussion of your seminar(s) this morning @harmitmalik.bsky.social ! Thank you, again, for a great visit! It was wonderful reconnecting.

23.10.2025 12:21 👍 1 🔁 0 💬 1 📌 0
Eleven members of the ASBMB Membership Committee smile and pose for a group photo at ASBMB's offices. They are standing in front of a bookcase lined with issues of the Journal of Biological Chemistry.

Eleven members of the ASBMB Membership Committee smile and pose for a group photo at ASBMB's offices. They are standing in front of a bookcase lined with issues of the Journal of Biological Chemistry.

Members of the ASBMB Membership Committee gather around a member who is holding a copy of the first issue of the Journal of Biological Chemistry, which was published in Oct. 1905. They issue of the journal is opened and two members are taking photos on their phones.

Members of the ASBMB Membership Committee gather around a member who is holding a copy of the first issue of the Journal of Biological Chemistry, which was published in Oct. 1905. They issue of the journal is opened and two members are taking photos on their phones.

Today's #TBT post celebrates 120 years of the Journal of Biological Chemistry! The first issue of JBC was published in Oct. 1905. Here's the ASBMB Membership Committee w/a copy of that first issue! It was a fun moment looking back as the membership committee looks to the future.
asbmb.org/membership

09.10.2025 20:06 👍 7 🔁 5 💬 0 📌 3

Thank you to everyone who joined our recent committee meeting! #ASBMBJournals #JbiolChem

📸 Committee members here on #Bluesky: @chifungleephd.bsky.social, @marinaholz.bsky.social & @drohsopretty.bsky.social.

09.10.2025 20:16 👍 6 🔁 5 💬 0 📌 0
Dr. Melanie McReynolds, queen of all things NAD+ in biochem dept at Penn State

Dr. Melanie McReynolds, queen of all things NAD+ in biochem dept at Penn State

Selfie with Dr. Seth Birdenstein, direction of microbiome institute at Penn state

Selfie with Dr. Seth Birdenstein, direction of microbiome institute at Penn state

Selfie with Dr. Seth Bordenatwin showing off some nice swag (socks) that advertise the microbiome center at Penn State

Selfie with Dr. Seth Bordenatwin showing off some nice swag (socks) that advertise the microbiome center at Penn State

Selfie with Dr. Nikki Crowley, director of neuroscience institute at Penn state

Selfie with Dr. Nikki Crowley, director of neuroscience institute at Penn state

Excellent first day at @pennstateuniv.bsky.social for the Marker lectures hanging out with science celebrities @nicoleacrowley.bsky.social @drohsopretty.bsky.social @symbionticism.bsky.social
plus several more folks I was too shy to ask for selfies

15.10.2025 02:19 👍 63 🔁 6 💬 5 📌 1

A great collaboration with the @drohsopretty.bsky.social lab examining the gut-liver axis: the enteroendocrine cells, enterohormones, metabolites, and lipid changes in MASLD and MASH models.

19.09.2025 18:37 👍 2 🔁 1 💬 0 📌 0

Congratulations to you as well!

04.08.2025 01:41 👍 0 🔁 0 💬 1 📌 0
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In a time as this— I am deeply thankful to be blessed with this honor. As a scientist and educator, the NSF CAREER award allows me to integrate the very core of who I am as a scientist and educator.

Forever grateful to past and present members of my lab for helping me accomplish this dream.

30.07.2025 18:19 👍 60 🔁 10 💬 4 📌 0