Renal and Urology News

Drs Uzzo, Chung, and Croll’s Takeaways From ASCO GU 2026 Drs Chung, Croll, and Uzzo share 6 of the most compelling study findings from the ASCO GU Cancers Symposium on February 26-28, 2026.

Drs. Rainjade Chung, Benjamin Croll, and Robert Uzzo share 6 of the most compelling study findings from the ASCO GU Cancers Symposium.

Read our latest editorial: www.renalandurologynews.com/features/asc... #NationalKidneyMonth #WorldKidneyDay

Low Baseline PSA Levels at Midlife Tied With Low Prostate Cancer Risk Over 20 Years Prostate cancer is on the rise globally, warranting more efficient screening methods.

A single PSA test at midlife may identify men with a low risk of prostate cancer for up to 20 years, supporting longer screening intervals.
www.renalandurologynews.com/news/prostat...

Phosphorus management has long been a cornerstone of care for patients with chronic kidney disease and end-stage kidney disease.

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Electronic Artificial Sphincter Device for Stress Urinary Incontinence Shows Early Promise The first human study of an electronic artificial urinary sphincter suggests it is a feasible treatment for men with stress urinary incontinence.

The electronic device was successfully implanted and activated in 6 men with SUI who experienced reduction in pad usage over 1 year.
www.renalandurologynews.com/news/stress-...

PLND May Offer No Survival Benefit in Prostate Cancer Treated With Surgery Plus Radiation Studies on whether pelvic lymph node dissection (PLND) provides a survival benefit in men with prostate cancer having surgery plus radiation have yielded conflicting results.

In patients undergoing RP with adjuvant radiation, PLND showed no survival benefit, regardless of prostate cancer risk group or number of lymph nodes removed.
www.renalandurologynews.com/news/plnd-su...

Sirolimus Lowers Cutaneous Squamous Cell Carcinoma Risk After Kidney Transplant A study supports targeted conversion of kidney transplant recipients with a history of cutaneous squamous cell carcinoma (cSCC) to sirolimus.

Switching to sirolimus significantly reduces the risk of subsequent cSCC in high-risk kidney transplant recipients with history of the skin cancer.
www.renalandurologynews.com/news/sirolim...

Metastasis-Directed Tx Shows ‘Robust’ Progression Benefit in Oligometastatic Prostate Cancer Metastasis-directed therapy for oligometastatic prostate cancer was associated with improved outcomes in a systematic review and meta-analysis.

This meta-analysis of 7 trials provides the highest level of evidence to date supporting MDT for selected patients with oligometastatic prostate cancer.
www.renalandurologynews.com/news/prostat... #prostatecancer

High-Deductible Health Plans Linked With Worse Cancer Survival Even patients with livable incomes and college educations might be at risk for poor cancer survival if they rely on high-deductible health plans, a study suggests.

Although cancer survivors with high-deductible health plans technically have insurance coverage, they have increased risks for poor survival.
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Active Surveillance Noninferior for High-Grade T1 Bladder Cancer, No Residual Tumor Careful monitoring is a new safe option for patients with high-grade T1 bladder cancer with negative results on a second transurethral resection, according to a trial.

Active surveillance is noninferior to BCG induction therapy for invasive relapse-free survival in patients with high-grade T1 bladder cancer with no residual tumor on second TURBT.
www.renalandurologynews.com/news/bladder... #bladdercancer

Faster Sodium Correction of Hyponatremia May Lower Mortality and Neurologic Risks Slower rates of sodium correction in hyponatremia may have gone too far in their attempts to prevent osmotic demyelination syndrome.

Treatment guidelines for severe hyponatremia should be reexamined to allow for faster sodium correction.
www.renalandurologynews.com/news/faster-...

Multiparametric MRI Anticipates Post-Nephrectomy Kidney Decline Loss of functional kidney tissue after nephrectomy for kidney cancer contributes to the onset of chronic kidney disease (CKD).

Preoperative MRI, specifically 9-b-value DWI and T1-mapping, helps predict if a patient will develop stage 3 CKD after partial or radical nephrectomy for kidney cancer.
www.renalandurologynews.com/news/ckd-mri... #kidneydisease

Bipolar Enucleation vs B-TURP Yields Better Outcomes for BPH in Large Prostates A randomized controlled trial compared the efficacy and safety of bipolar enucleation vs bipolar TURP in men with large prostates and benign prostatic hyperplasia (BPH).

Bipolar enucleation significantly reduced IPSS in men with large prostates and obstructed bladder necks, but the procedure led to a high rate of retrograde ejaculation.
www.renalandurologynews.com/news/benign-...

Autovaccine Reawakens the Immune System in the ‘Cold’ Prostate Cancer Microenvironment Investigators tested a new neoadjuvant immunotherapy to fight prostate cancer using a virus-mimicking drug to activate the immune system.

An early clinical trial is suggesting that directly injecting an immune-activating compound into prostate tumors before surgery is safe and may help the innate and adaptive immune system recognize and attack cancer cells.

Read our latest feature: www.renalandurologynews.com/features/aut...

BPH Retreatment Rates Lowest After Simple Prostatectomy, HoLEP, ThuLEP Retreatment after benign prostatic hyperplasia (BPH) procedures appear lowest for men undergoing simple prostatectomy, HoLEP, or ThuLEP, compared with TURP.

In a real-world study, minimally invasive surgical treatments such as Rezūm and PUL were associated with higher rates of retreatment and medication reinitiation compared with TURP. Findings may inform expectations regarding treatment durability.
www.renalandurologynews.com/news/benign-...

Robotic Transperineal Fusion Biopsy and RP Pathology Have High Concordance Robotic-assisted transperineal fusion biopsy led to relatively low rates of prostate cancer upgrading and downgrading in a single-center study.

Pathologic concordance between prostate biopsy and radical prostatectomy improves with use of a novel robotic-assisted transperineal fusion biopsy platform. Optimization of risk stratification at prostate biopsy has implications for focal therapy use.
www.renalandurologynews.com/news/prostat...

Artificial Urinary Sphincter Has High Continence Rate With Acceptable Complications Artificial urinary sphincter implantation is an effective option with an acceptable complication rate for moderate to severe stress urinary incontinence.

Most men with post-procedural stress urinary incontinence in a prospective study achieved at least halving of pad use within 12 months.
www.renalandurologynews.com/news/artific...

Targeted Perilesional Biopsy Noninferior to Combined Targeted, Systematic Prostate Biopsy Optimal prostate biopsy should capture all clinically relevant prostate cancers with the least biopsy cores.

In a randomized trial of men with a single suspicious lesion on MRI, targeted perilesional biopsy matched standard targeted and systematic biopsy for detecting clinically significant prostate cancer -- with fewer complications.
www.renalandurologynews.com/news/prostat... #prostatecancer

AUA Releases 2026 Kidney Stone Surgery Guideline More than 370,000 insured patients in the United States underwent surgery for ureteral and kidney stones in 2019, highlighting the importance of the 2026 AUA guideline.

The American Urological Association (AUA) has issued a new guideline on the surgical management of kidney and ureteral stones in a 3-part series published in The Journal of Urology.

Read our latest feature: www.renalandurologynews.com/features/aua...

Enzalutamide With or Without Leuprolide Shows Efficacy in High-Risk Prostate Cancer BCR Secondary endpoint data from the EMBARK trial support use of enzalutamide treatments in patients with high-risk biochemically recurrent prostate cancer.

Based on EMBARK data, both enzalutamide monotherapy and combination therapy (with leuprolide) reduced the likelihood of distant metastasis in patients with high-risk biochemically recurrent prostate cancer.
www.renalandurologynews.com/news/high-ri... #prostatecancer

Model Predicts Prostate Cancer Mortality at the Point of PSA Screening Investigators designed and externally validated a prostate cancer death prediction model for risk stratification of men at the point of PSA screening.

The PLCO model may improve prediction of prostate cancer death at the point of screening. The Stockholm3 test may improve screening itself.
www.renalandurologynews.com/news/prostat... #prostatecancer

Ethical Dilemmas in End-of-Life Care Quality communication about end-of-life care ensures that medical treatments or interventions align with patients’ values and preferences.

Discomfort with death relates to a number of challenging situations and resulting ethical dilemmas, some of which may originate from unspoken or inadequately articulated goals of care.

Read our latest feature: www.renalandurologynews.com/features/end...

FANS With URS Noninferior to Mini PCNL for Larger Kidney Stones Using a flexible and navigable suction ureteral access sheath (FANS) rather than mini-percutaneous nephrolithotomy (PCNL) for 2-3 cm kidney stones has been controversial.

In a randomized trial, FANS f-URS and mini-PCNL had comparable immediate stone clearance rates.
www.renalandurologynews.com/news/kidney-... #kidneystones

Cribriform Prostate Cancer Has Higher Risk of Metastasis, Might Benefit From RT There is increasing recognition of cribriform morphology as a predictor of poor prostate cancer outcomes.

Cribriform carcinoma and/or intraductal carcinoma on prostate histopathology was associated with higher rates of metastasis.
www.renalandurologynews.com/news/cribrif... #prostatecancer

Preventing Recurrent Kidney Stones Requires Personalized Diet, Lifestyle Recs Beyond broad recommendations for recurrent kidney stone prevention, clinicians and renal dietitians can create personalized plans.

While patients with multiple risk factors for kidney stones may receive broad, generalized advice, preventing recurrence requires precision and an individualized plan.

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#kidneystones

Chronic Kidney Disease a Risk Factor for Severe West Nile Neuroinvasive Disease West Nile virus is the leading mosquito-borne infection in the United States. Neuroinvasive disease affects less than 1% but it can be fatal.

Patients with CKD are among those at increased risk for West Nile neuroinvasive disease and have nearly twice the risk of dying from the disease.
www.renalandurologynews.com/news/chronic... #kidneydisease

Persistent Hematuria Predicts Poor Lupus Nephritis Prognosis Rather than a secondary finding, hematuria might be a prognostic biomarker in lupus nephritis.

Persistent hematuria in patients diagnosed with lupus nephritis independently predicts adverse outcomes.
www.renalandurologynews.com/news/hematur... #lupus

Combining RARP With ADT Prolongs Survival in Oligometastatic Prostate Cancer - Renal and Urology News The standard-of-care for oligometastatic prostate cancer centers on systemic therapy including ADT.

Multimodal treatment including radical prostatectomy might lead to improved survival in patients with oligometastatic prostate cancer treated with ADT.
www.renalandurologynews.com/reports/pros... #SUO2025 #prostatecancer

PSA Decline May Be Greater With Apalutamide vs Abiraterone for mCSPC - Renal and Urology News Investigators compared PSA90 response between new users of apalutamide vs abiraterone for mCSPC using a large US cohort.

Among real-world US patients with mCSPC, apalutamide users achieved PSA90 response approximately 5 months earlier than abiraterone users, with more achieving deeper PSA decline.
www.renalandurologynews.com/reports/psa-... #SUO2025 #prostatecancer

Non-Muscle Invasive Bladder Cancer That Metastasizes Has Poor Survival - Renal and Urology News Metastatic NMIBC is underexplored with prognosis unclear.

Overall survival is no better for patients diagnosed with NMIBC who progress directly to metastasis.
www.renalandurologynews.com/reports/non-... #SUO2025 #bladdercancer

Should Cytoreductive Nephrectomy be Revitalized in Metastatic RCC? - Renal and Urology News In 2024, only 5% of real-world patients with mRCC in a large database underwent cytoreductive nephrectomy.

Cytoreductive nephrectomy merits further consideration in appropriately risk-stratified, surgically fit patients with mRCC.
www.renalandurologynews.com/reports/cyto... #SUO2025 #kidneycancer