Non Lee

Michigan resident dies from rabies after contracting virus from organ transplant, health officials say A Michigan resident died of rabies after receiving a transplanted organ in Ohio, county health officials say.

A Michigan resident has died of rabies after receiving a transplanted organ in Ohio, the Toledo-Lucas County (Ohio) Health Department reported Wednesday.

Metabolic profiling and antibacterial activity of tree wood extracts obtained under variable extraction conditions - Metabolomics Introduction Tree bacterial diseases are a threat in forestry due to their increasing incidence and severity. Understanding tree defence mechanisms requires evaluating metabolic changes arising during...

Metabolic profiling and antibacterial activity of tree wood extracts obtained under variable extraction conditions #Metabolomics #MassSpec link.springer.com/article/10.1...

In 1956, L. Ferenczy published a paper documenting that plant seeds from various plant species, including those from Cannabis sativa, exhibited antibacterial activity, especially against Gram-positive bacteria [64]. Wasim et al. [65] documented that both ethanolic and petroleum ether extracts of Cannabis sativa leaves showed anti-microbial activity against Bacillus subtilis, Staphylococcus aureus, Micrococcus flavus, Bordetella bronchiseptica, Proteus vulgaris, Aspergillus niger, and Candida albicans. Ali et al. [66] observed that the oil of the seeds of Cannabis sativa exerted pronounced anti-bacterial activity against Bacillus subtilis and Staphylococcus aureus, with moderate activity against Escherichia coli and Pseudomonas aeruginosa, without any activity against Aspergillus niger and Candida albicans.

Nissen et al. [34] observed that essential oils of Cannabis sativa L., prepared from 50–70% of seed maturity, showed anti-bacterial activity against the Gram-positive bacteria Enterococcus faecium and Streptococcus salivarius at less than 1% (v/v) but were unable to inhibit the growth of the yeast Saccharomyces cerevisiae. Zengin et al. [68] found that essential oils distilled from leaves, inflorescences, and thinner stems of the hemp plant showed anti-oxidative properties and had significant anti-bacterial activity against clinical Helicobacter pylori strains (MIC = 16–64 μg/mL), with lower activity against clinical Staphylococcus aureus isolates (MIC = 8 mg/mL) and no significant activity against Candida spp. and Malassezia spp. The minimum bacterial biofilm inhibitory concentration (MBIC) of the hemp essential oil against Helicobacter pyroli was similar to the MIC [68]. The hemp essential oil showed cytotoxicity against human breast cancer, cholangiocarcinoma, and colon carcinoma ce

It sure is interesting how many parallels there are being Seizures and [The Asag], like you can banish the demon with the same plant stuff that can help seizures. (This also fights S. Aureus)
www.mdpi.com/2227-9059/10...

Evaluation of antibacterial activity of ethanolic extracts of Ruta chalepensis, Hippocratea excelsa, Litsea glaucescens and Waltheria americana against methicillin-resistant Staphylococcus aureus https://www.biorxiv.org/content/10.1101/2024.09.27.615392v1 Antimicrobial resistance is still a problem today, with increasingly limited therapeutic options. St

Evaluation of antibacterial activity of ethanolic extracts of Ruta chalepensis, Hippocratea excelsa, Litsea glaucescens and Waltheria americana against methicillin-resistant Staphylococcus aureus https://www.biorxiv.org/content/10.1101/2024.09.27.615392v1

New research powered by MicrobesNG—highlights from our global research community! 🌍🔬

Candida parapsilosis can cause serious infections in immunocompromised patients.

New Scientific Reports study looks at impacts of fluconazole resistance in hospital isolates using phenotypic & genomic analyses.

Cell-autonomous innate immunity by proteasome-derived defence peptides Nature - Proteasomal degradation of cellular proteins generate defence peptides constitutively and in response to bacterial infection. Such peptides might provide a source of natural antibiotics...

rdcu.be/ecwJ9

One of the coolest studies of last year would not be funded by the current NIH policy. By studying people undergoing gender affirming testosterone treatment, they discovered how sex hormones shape the #immune response, with important consequences for everyone!
www.nature.com/articles/s41...

Evolution of Small Molecule Inhibitors of Mycobacterium tuberculosis Menaquinone Biosynthesis A dire need exists for novel drugs to treat Mycobacterium tuberculosis infection. In an effort to build on our early efforts targeting the MenG enzyme within the menaquinone biosynthetic pathway, we have pursued the optimization of diaryl amide JSF-2911 to address its poor metabolic stability and modest in vitro potency. A hit evolution campaign focused on modification of the amine substructure within this hit compound, resulting in a range of analogues that have been profiled extensively. Among these derivatives, JSF-4536 and JSF-4898 demonstrated significantly improved biological profiles, notably offering submicromolar MIC values versus M. tuberculosis and promising values characterizing the mouse liver microsome stability, aqueous solubility, and mouse pharmacokinetic profile. JSF-4898 enhanced the efficacy of rifampicin in a subacute model of M. tuberculosis infection in mice. The findings suggest a rationale for the further optimization of MenG inhibitors to provide a novel therapeutic strategy to address M. tuberculosis infection.

We are excited to announce publication of our work on M. tuberculosis MenG inhibitors in J. Med. Chem.. Many thanks to our lab members who contributed in collaboration with the Sarathy, Zimmerman, Nelson, and Alland labs. Please check it out at: pubs.acs.org/doi/10.1021/...

oh cool I’ve been meaning to learn anxiety

☁️Final paper in the MccStudy special collection, led by the #EHMLab at LSHTM, looks into the impact of #AirPollution mixtures on the toxicity of fine particulate matter (PM2.5)

Read more👉 bit.ly/3R3LiZY

Explore the collection on @Environmental Epidemiology

👉 bit.ly/4iD9fTi

Rise of vaccine distrust - why more of us are questioning jabs Confidence in all types of vaccination has taken a hit. The question is why, and what can be done about it?

Rise of vaccine distrust - why more of us are questioning jabs

In BBC News Heidi Larson highlights concerns over data suggesting biggest falls in #vaccine confidence among younger groups, & more widely since #COVID-19 pandemic. #PublicHealth

👉 www.bbc.co.uk/news/article...

Preview: Gasping for air: HIF2α in asthma
www.cell.com/immunity/ful...
@poholeklab.bsky.social
on
www.cell.com/immunity/ful...

Fungal symbiont transmitted by free-living mice promotes type 2 immunity - Nature Kazachstania pintolopesii is a highly prevalent fungal symbiont that can trigger type 2 immunity and influence the composition of the gut mycobiome, as well as immune and disease phenotypes.

Super interesting new study from the Iliev group on a natural fungal commensal of mice - really important for folks studying #microbiome in mouse models
www.nature.com/articles/s41...

Receptor rearrangement, naive T cells, selection, clonal expansion, effector T cells, apoptosis, contraction, memory T cells, reactivation.

Difficult terms if you are not familiar with them. But important to familiarise with the meaning to understand some immunology.
1/8

REVIEW: Next-generation combination approaches for immune checkpoint therapy
www.nature.com/articles/s41...
@pamsharmamdphd.bsky.social

Regional variations in serum IL-35 levels and association with systemic lupus erythematosus: a systematic review and meta-analysis - Scientific Reports Scientific Reports - Regional variations in serum IL-35 levels and association with systemic lupus erythematosus: a systematic review and meta-analysis

Our recent work demonstrated variations in circulating IL-35 levels in the serum of systemic lupus erythematosus (SLE) patients, comparing those in China with those from other regions.
Read more here!
#SLE
#ScientificReport
#Autoimmune

I would like to join, may I be added?

Could you please add me? Thanks

Thanks for making the community!

Symptomatic Entamoeba dispar Infections Among Men Who Have Sex With Men, New York City, 2018 Abstract. Entamoeba histolytica is considered the primary species causing the parasitic gastrointestinal infection amebiasis. A cluster of amebiasis infect

Symptomatic Entamoeba dispar Infections Among Men Who Have Sex With Men, New York City, 2018

🤔🤔🤔 #IDsky

academic.oup.com/ofid/advance...

Regional variations in serum IL-35 levels and association with systemic lupus erythematosus: a systematic review and meta-analysis - Scientific Reports Scientific Reports - Regional variations in serum IL-35 levels and association with systemic lupus erythematosus: a systematic review and meta-analysis

Our recent work demonstrated variations in circulating IL-35 levels in the serum of systemic lupus erythematosus (SLE) patients, comparing those in China with those from other regions.
Read more here!
#SLE
#ScientificReport
#Autoimmune

Characterization of a GpsB-associated regulator of PBP1a reveals the organization of the cell wall remodeling complex of Streptococcus pneumoniae https://www.biorxiv.org/content/10.1101/2024.11.09.622756v1 Class A PBPs (aPBPs) play a key role in the biosynthesis and remodeling of peptidoglycan, the main c

Characterization of a GpsB-associated regulator of PBP1a reveals the organization of the cell wall remodeling complex of Streptococcus pneumoniae https://www.biorxiv.org/content/10.1101/2024.11.09.622756v1

Monocytes and their doppelgängers: An immunological crossroads Monocyte research reveals “doppelgänger” populations that resemble classical monocytes but differ in origin, function, or migration.

Immune cell subsetting! 🤯
#immunosky
www.science.org/doi/10.1126/...

Assistant Professor (Research and Education) Microbiology - School of Biosciences - 103676 - Grade 8 You will contribute to a range of research, teaching and administration. In addition you will be expected to demonstrate academic citizenship, developing and maintaining generous, mutually respectful ...

We have an assistant professor post in molecular microbiology available in the School of Biosciences/Institute of Microbiology and Infection at the University of Birmingham - come join us!
edzz.fa.em3.oraclecloud.com/hcmUI/Candid...

So much progress translating our understanding of cytokine signalling into 🩺therapies.

Mostly in #rheumatology, but maybe in #IDSky too one day... 🧪🦠

www.thelancet.com/jo...

Comparative safety of different antibiotic regimens for the treatment of outpatient community-acquired pneumonia among otherwise healthy adults AbstractBackground. Evidence is limited about the comparative safety of antibiotic regimens for treatment of community-acquired pneumonia (CAP). We compare

This is a bit odd. Sure some antibiotics have more adverse effects, but you've got to trade that off against their efficacy (Beta lactam better) and also the severity of AE (C diff bad, but most GI effects are transient)
#IDSky 🩺 🧪 🦠

academic.oup.com/cid/advance-...

Zidovudine in synergistic combination with nitrofurantoin or omadacycline: in vitro and in murine urinary tract or lung infection evaluation against multidrug-resistant Klebsiella pneumoniae | Antimic... With antibiotic resistance rapidly spreading, multidrug-resistant (MDR) Gram-negative bacteria (GNB) have become a major public health concern, threatening our ability to effectively treat bacterial i...

Zidovidina (AZT) para Klebsiella? #pneumonia #urossepse #ITU #sepse #invitro #infectologia #Klebsiella #Enterobacterales journals.asm.org/doi/10.1128/...

Bacterial capsules: Occurrence, mechanism, and function - npj Biofilms and Microbiomes npj Biofilms and Microbiomes - Bacterial capsules: Occurrence, mechanism, and function

A nice review on #capsules, their synthesis and functions

IMHO, it has the added value that it expands beyond the traditional, most studied capsules (colanic acid, Strep pneumo, #Klebsiella).

www.nature.com/articles/s41...

Klebsiella pneumoniae é um dos 3 agentes mais prevalentes em #IRAs. Estima-se que seja agente etiológico de 20-30% das pneumonias nosocomiais na Região das Américas. OMS aponta surgimento de cepa hipervirulenta hvKp. www.who.int/emergencies/... #infectiousdesease #sepse #klebsiella #infectologia