Did I mention that we made the cover @jci.org?! Artwork from the amazing @quanamadison.bsky.social, who completed our CircaPain.ca study, represents the potential she sees for improving pain relief by restoring circadian rhythmicity.
We're now looking to understand how circadian rhythms affect pain in preclinical models, dissecting the mechanisms involved at the molecular, cellular, and systems levels. Super excited about all the directions this work will take in the years to come!
It wouldn't have been possible without the support of @cpn-rdc.bsky.social who provided the seed funding for this project. Now funded by the Canadian Institutes of Health Research, our www.circapain.ca study seeks to expand these findings across pain conditions.
Collaborators include @qinglingduan.bsky.social, @gabriellepage.bsky.social, Luda Diatchenko, Zihang Lu, and Manon Choinière -- a true team effort across @queensuresearch.bsky.social, @umontreal.ca, and @mcgill.ca.
This work was led by three talented PhD students (Doriana Taccardi, Amanda Zacharias, and Hailey Gowdy) who brought their expertise to elevate this work to new heights. Our patient-partners (Lesley Singer and Jennifer Daly-Cyr) were instrumental in study design and analysis.
We've published our very first clinical study where we found that chronic low back pain rhythmicity contributes to biopsychosocial outcomes, including opioid use, via the neutrophil degranulation pathway t.co/0yFdJemScW
Looking forward to seeing everyone in Toronto soon!
Are you an American or international trainee considering a PhD or postdoc in pain, neuroimmunology, and/or chronobiology? Our federal funding just added eligibility for international applicants at Cdn institutions, and we’d love to have you! Send me an email to connect… ghasemloulab.ca CircaPain.ca
my first post to @bsky.app and first like from @altnih4science.bsky.social! that was cool, even for a canadian :)
"Anyone accessing this web site expressly consents to monitoring of their actions and all communication or data transiting or stored on or related to this web site and is advised that... NIH may provide that evidence to law enforcement officials."
"Unauthorized attempts to upload information, change information, or use of this web site may result in disciplinary action, civil, and/or criminal penalties. Unauthorized users of this web site should have no expectation of privacy regarding any communications or data processed by this web site."
"You are accessing a U.S. Government web site which may contain information that must be protected under the U. S. Privacy Act or other sensitive information and is intended for Government authorized use only."
Especially since I'm not in cancer research, would need the advice of: @altnih4science.bsky.social @cancerresearchuk.org @theaacr.bsky.social @acscan.bsky.social @ascocancer.bsky.social
What the actual fuck is this?!
Was at a great talk, an interesting gene name came up, put it into the #nationalcancerinstitute Genomic Data Commons site and got this. Has this warning always been here? Because some of the warning message comes across as quite Orwellian...
