Lecuit Lab

Please note this interesting symposium, organised by the Louis Jeantet Foundation in Geneva, which can also be followed remotely.
#LouisJeantetSymposium

We are hiring a postdoc in bacterial genomics and evolution.
research.pasteur.fr/wp-content/u...

thanks Mart!

"Chairs of Excellence in Biology/Health": two new Institut Pasteur laureates The Institut Pasteur is delighted that two of the winners of the new "Chairs of Excellence in Biology/Health" call for proposals round launched by the French National Research Agency (ANR) are its own...

🏆 Congratulations to Simonetta Gribaldo @sgribaldo.bsky.social and Marc Lecuit @biupasteur.bsky.social !
Our two researchers have been awarded prestigious ANR Chairs of Excellence in Biology/Health for their innovative projects.

Chikungunya virus and other emerging arthritogenic alphaviruses Nature Reviews Microbiology, Published online: 07 May 2025; doi:10.1038/s41579-025-01177-8In this Review, Weaver and colleagues discuss the transmission cycles of arthritogenic alphaviruses, their vectors, epidemiology, transmission dynamics, evolution, pathophysiology and immune responses. They also outline strategies and countermeasures to anticipate and mitigate the impact of arthritogenic alphaviruses on human health.

New online! Chikungunya virus and other emerging arthritogenic alphaviruses

Chikungunya virus and other emerging arthritogenic alphaviruses - Nature Reviews Microbiology In this Review, Weaver and colleagues discuss the transmission cycles of arthritogenic alphaviruses, their vectors, epidemiology, transmission dynamics, evolution, pathophysiology and immune responses...

Chikungunya virus and other emerging arthritogenic alphaviruses

www.nature.com/articles/s41...

Funded postdoctoral position in the Lecuit lab at Institut Pasteur - Research

We are hiring!
Interested in infection biology, immunology, microbiology?
Funded postdoctoral position in our lab at Institut Pasteur research.pasteur.fr/en/team/biol...
@inserm.fr

Contact us at postdoc.biu@pasteur.fr
research.pasteur.fr/en/job/funde...

Bravo
@alqurefa et al!
A great study to which the Southeast Asia Encephalitis Consortium is honored to have contributed.
www.thelancet.com/journals/lan...

📢NOMINATIONS for the 2026 #LouisJeantetPrize and #CollenJeantetPrize are open. Support great #EuropeanResearch and submit your nomination by February 21, 2025.
🙏Please share!
jeantet.ch/en/nominatio...

well done Lukas! bravo.

6/6 Thanks to everybody involved, including Enzo Gadin, Arthur Frouin, Olivier Disson, Lei Huang, Charlotte Gaultier, Afonso Vieira, @clairemaudet.bsky.social, @epcrocha.bsky.social, Hugues Aschard, @pasteur.fr, @inserm.bsky.social

Differential stress responsiveness determines intraspecies virulence heterogeneity and host adaptation in Listeria monocytogenes - Nature Microbiology Differences in virulence across the Listeria monocytogenes species are determined by the fine-tuning of SigB pathway responsiveness and reflect host adaptation.

1/6 Excited to share our new findings published today in
@naturemicrobiol.bsky.social, explaining what drives virulence heterogeneity in Listeria monocytogenes!
@lukashafner.bsky.social
@biupasteur.bsky.social
www.nature.com/articles/s41...

Differential stress responsiveness determines virulence heterogeneity in Listeria monocytogenes YouTube video by Lukas Hafner

2/6 Previously, bacterial virulence was thought to reflect the content of core virulence genes as well as the presence of accessory virulence genes, which account for virulence heterogeneity.
www.youtube.com/watch?v=liJm...

Differential stress responsiveness determines virulence heterogeneity in Listeria monocytogenes YouTube video by Lukas Hafner

www.youtube.com/watch?v=liJm...

Differential stress responsiveness determines intraspecies virulence heterogeneity and host adaptation in Listeria monocytogenes - Nature Microbiology Differences in virulence across the Listeria monocytogenes species are determined by the fine-tuning of SigB pathway responsiveness and reflect host adaptation.

copying form X to bluesky does not always work... sorry!
www.nature.com/articles/s41...

Differential stress responsiveness determines intraspecies virulence heterogeneity and host adaptation in Listeria monocytogenes - Nature Microbiology Differences in virulence across the Listeria monocytogenes species are determined by the fine-tuning of SigB pathway responsiveness and reflect host adaptation.

www.nature.com/articles/s41...

The Listeria National Reference Center and WHO Collaborating Center, and many more!

Bacterial inhibition of Fas-mediated killing promotes neuroinvasion and persistence - Nature Studies in a mouse model of neurolisteriosis show that the effector protein InlB produced by Listeria monocytogenes protects infected monocytes in the host from T cell-mediated cell death, and thereby...

5/6 It also sheds light on the mechanism by which certain Listeria monocytogenes clonal complexes are more virulent, host associated, and clinically associated than others, as we also reported www.nature.com/articles/s41...

Uncovering Listeria monocytogenes hypervirulence by harnessing its biodiversity - Nature Genetics Marc Lecuit, Sylvain Brisse and colleagues combine Listeria monocytogenes population genomic data with human epidemiological and clinical data to study human listeriosis. They report new putative viru...

4/6 This unique overarching mechanism, which is unexpected, explains the overall virulence heterogeneity of Listeria monocytogenes species - from isolates to lineages, as we had reported www.nature.com/articles/ng....

3/6 Here, we have identified a new mechanism that explains virulence heterogeneity, not by gene content but by the differential regulation of core virulence genes, driven by differential stress response.

👏👏👏Congratulations to Lukas & all co-authors