Kaia Mattioli

Looking forward to @kaiamattioli.bsky.social's visit to Montreal!

Individualized mRNA vaccines evoke durable T cell immunity in adjuvant TNBC - Nature In a phase 1 trial, personalized mRNA vaccines tailored to individual tumour mutations in triple-negative breast cancer induced robust, long-lasting T cell responses and improved prognosis.

I remain bullish on personalized cancer vaccines. great to see this for TNBC!
www.nature.com/articles/s41...

Matched single-cell chromatin, transcriptome, and surface marker profiling captures in vivo epigenomic reprogramming during basal-to-luminal transition in the mammary gland https://www.biorxiv.org/content/10.64898/2026.02.16.706078v1

💀💀 ugh the good old days

The best one is still when is it ok to send emails

I am currently living the dream (eating loaded nachos and drinking a glass of sauv blanc in a hotel lobby by myself while I decompress by reading a new fantasy book after talking science all day) AMA

Mechanisms linking cytoplasmic decay of translation-defective mRNA to transcriptional adaptation Transcriptional adaptation (TA) is a genetic robustness mechanism through which mutant messenger RNA (mRNA) decay induces sequence-dependent up-regulation of so-called adapting genes. How cytoplasmica...

This is a fascinating paper that reveals defined and clear mechanism for a phenomenon that for some seemed unbelievable- the up regulation of genes paralogous to those with specific types of inactivating mutations. This is called transcriptional adaptation 1/ www.science.org/doi/10.1126/...

wow I loveeee to find a new fantasy series with Complicated Rules (just started The Will of the Many)

one of my favorite papers recently -- obsessed with @alexholehouse.bsky.social & team's work!

Pleased to share the final version of this behemoth of a paper, now finally published. I guess I can retire now?
www.nature.com/articles/s41...

More functional data, many thousands of words removed, and a few other updates from last year's preprint.

my baby is 2 😭😭 being his mom is the absolute best thing in the entire universe 🪐

Tenuous biomedical funding has put first-year Ph.D. students in a bind First-year biomedical graduate students across the country said labs have been hesitant to take them in due to a tenuous funding environment

With continued uncertainty over federal government support for biomedical research, PhD students are struggling to find labs willing to take on new students, @jonathanwosen.bsky.social reports.
New students are the future of US science. www.statnews.com/2026/01/30/f...

We are thrilled that our study on the evolution of gene regulation in mammalian cerebellum development – led by @ioansarr.bsky.social, @marisepp.bsky.social and @tyamadat.bsky.social, in collaboration with @steinaerts.bsky.social – is now out in @ScienceMagazine! www.science.org/doi/10.1126/...

oh yeah that's an automatic leave situation. we only go at 5:30 and immediately order French fries as we are being seated lol

Original post was deleted but this was in response to Apple TV buying the rights to the Cosmere 😱

omg huge news

10° and snowing in Boston and I've already seen 2 people out running and 1 guy with a giant iced Dunks

going out to dinner with your 2 year old is actually totally cool and fine if you understand that, like a bomb, they are going to detonate in exactly 48 minutes. you better be outta there not one second later

Oooo this sounds great!

(also my ipad is now so old that it won't let me update netflix, meaning i can't use it to watch love is blind on airplanes, which is a very important part of my life, so i WILL be getting a new one)

do any of you read papers primarily on a tablet? if so, what tablet + apps do you use? at some point i transitioned from reading on my laptop to printing papers like an Old, but my desk is becoming a Problem so i'm looking to switch it up

mRNA neoantigen vaccines appear to be working for multiple cancers

feeds.issuerdirect.com/news-release...

hahah word. tbt to when our grad student recruitment class of 2016 got snowed in during interview weekend of boston's snowpocalypse year...

it will never not be funny to me that we as a society have decided that interview season should be in the dead of winter, when ice-snow-tornado-monsoons can bring the nation's air travel to a halt unpredictably

Common variation in meiosis genes shapes human recombination and aneuploidy - Nature Analysis of data from pre-implantation genetic testing sheds light on the genetic basis of meiotic-origin aneuploidy, the leading cause of human pregnancy loss, identifying common genetic variants ass...

Pregnancy loss is common in humans, and chromosomal abnormalities are the leading cause. Using genetic data from ~140,000 IVF embryos, we show that maternal variation in meiosis genes influences recombination and aneuploidy risk.

First authors: @saracarioscia.bsky.social & @aabiddanda.github.io

US science after a year of Trump: what has been lost and what remains A series of graphics reveals how the Trump administration has sought historic cuts to science and the research workforce.

Great overview of the damage to science over the past year.

This shows NIH awarded 24% fewer new research awards in FY2025 vs 2024.

The multiyear funding language in the new LHHS bill means we should expect the same amount of new science this year.

www.nature.com/immersive/d4...

sending it into 2026 🥰

thank you, I hope I can!!

independently funded for my entire PhD and postdoc and now, when I need support, the system is collapsing from under me. can't think too deeply about how my family planning timeline affected these things or I go to a dark place 🫠

rarely in my career have I been as stressed as I am now: on the (extremely competitive) faculty job market, with a toddler, trying to get an extension on my K99 so I don't lose my R00, while NIH is stretched thin, grant reviews are delayed, and funding is very scarce.