Shalini Agarwal

Happy to have received a poster prize at the UK #Autophagy and #Proteostasis Conference!
Grateful to receive it from one of the leading figures in the field of proteostasis (@annebertolotti.bsky.social). A special thank you to the organisers for such a vibrant and insightful meeting!!

Michael Lazarou and I will be chairing the 11th International Symposium on Autophagy (ISA) in Australia from 16-20 Nov 2025!
📍 Location: Lorne, Victoria, Australia
🌐 Register now: www.isa11.org
Join us for five inspiring days of cutting-edge autophagy research and networking opportunities.

The bridge-like lipid transport protein VPS13C/PARK23 mediates ER–lysosome contacts following lysosome damage Nature Cell Biology - Wang et al. show the recruitment of the lipid channel protein VPS13C and formation of VPS13C-dependent contacts between endoplasmic reticulum and lysosomes after lysosomal...

"The bridge-like lipid transport protein VPS13C/PARK23 mediates ER–lysosome contacts following lysosome damage" out now in Nature Cell Biology
rdcu.be/ehbaL

Kinome screening identifies integrated stress response kinase EIF2AK1/HRI as a negative regulator of PINK1 mitophagy signaling Loss-of-function mutations in the PINK1 kinase lead to early-onset Parkinson’s disease (PD). PINK1 is activated by mitochondrial damage to phosphorylate ubiquitin and Parkin, triggering mitophagy. PIN...

Kinome screening identifies integrated stress response kinase EIF2AK1/HRI as a negative regulator of PINK1 mitophagy signaling
pmc.ncbi.nlm.nih.gov/articles/PMC...

MRC PPU on X: "MRCPPU researchers discover new drug target for #Parkinson’s disease https://t.co/b2bvyvahXN https://t.co/6NMtKWpXct" / X MRCPPU researchers discover new drug target for #Parkinson’s disease https://t.co/b2bvyvahXN https://t.co/6NMtKWpXct

x.com/mrcppu/statu...

Kinome screening identifies integrated stress response kinase EIF2AK1/HRI as a negative regulator of PINK1 mitophagy signaling EIF2AK1/HRI kinase negatively regulates PINK1 mitophagy.

Excited that our work revealing the regulation of PINK1 by ISR pathway, is out now! A new regulatory axis in mitophagy and mitochondrial quality control #mitophagy #Pink1 #mitochondria #ISR #Neurodegeneration
@mrcppu.bsky.social

www.science.org/doi/10.1126/...