Sounak Sahu

Network with stem cell leaders at ISSCR 2026. Learn more.

#ISSCR2026 offers exclusive networking opportunities designed to connect you with researchers driving the future of stem cell science. Make connections that progress your research forward and join me at @ISSCR.org 2026 in Montréal, Canada this July. invt.io/1bxbvz1ylsa

ISSCR 2026 abstract submission ends 25 February. Learn more.

Open doors to new collaborations, mentorship, and global recognition in the stem cell community by presenting your research at #ISSCR2026. Abstracts are due 25 February to be considered for oral presentations and travel & merit awards. invt.io/1bxbuzd87lg @isscr.org

✨ New Year, New Lab, New Beginnings ✨ Join us in New York as we are building our team. We are interested in understanding the molecular and cellular mechanisms underlying human breast development, tissue homeostasis, and breast cancer. www.sahulab.com Please RT.

Only in Shenzhen: Science Nature coffee bar. If you’ve published in @science.org or @nature.com, they give you coffee for free. 100% real!

Join us for a day long workshop on Human Organoids featuring cutting edge science, including our keynote talk by Prof. Dan Huh from U Penn. Registration is required, but free! Zoom link available on request. 🧪

Submit an Abstract by 25 February. Learn more.

The abstract submission deadline for #ISSCR2026 is coming up on 25 February! Submit your research to showcase your findings, connect with global experts, and gain visibility. Travel awards are available for early career researchers. Learn more: invt.io/1bxbl2mzc2q @ISSCR.org

Whole-genome landscapes of 1,364 breast cancers | Nature Breast cancer remains a major global health challenge1. Here, to comprehensively characterize its genomic landscape and the clinical significance of genomic characteristics, we analysed whole-genome sequences from 1,364 clinically annotated breast cancers, with transcriptome data available for most cases. Our study expands the repertoire of oncogenic alterations and identifies novel driver genes, recurrent gene fusions, structural variants and copy number alterations. Timing analyses on copy number alterations suggest that genomic instability emerges decades before tumour diagnosis, and offer insights into early initiation of tumorigenesis. Pattern-driven genomic features, including mutational signatures2, homologous recombination deficiency3, tumour mutational burden and tumour heterogeneity scores4, were associated with clinical outcomes, highlighting their potential utility as predictive biomarkers for clinical evaluation of treatments such as CDK4/6 and HER2 inhibitors, as well as

Analyzed 1,364 breast cancer genomes revealing new driver genes, fusions, and copy number changes. Major step for understanding breast cancer genomics. PMID:41339552, Nature 2025, @Nature https://doi.org/10.1038/s41586-025-09812-3 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

🚨 POSTDOC OPENING 🚨
NIH-funded Bio-Fluid Mechanics Postdoc in my lab @univmiami.bsky.social
Hofstenia miamia | cilia-driven flows | behavior & neuroscience
Collab w/ Mansi Srivastava @harvard.edu
🕒 Start: Jan–Feb 2026
⏳ 1 yr, renewable | Email me ASAP!
#Postdoc #Biophysics #FluidDynamics

Join me at the ISSCR 2026 Annual Meeting! Register now

Showcase your research on a global stage at #ISSCR2026! Submit an abstract by 25 February to share your latest stem cell discoveries, translational insights, or clinical advances. Research from all sectors is welcome - academia, industry, and beyond! invt.io/1bxb7k97inn @ISSCR.org

Anti-progestin therapy targets hallmarks of breast cancer risk Nature - Results of an early-phase breast cancer prevention trial demonstrate the potential for breast cancer prevention in premenopausal women with anti-progestin therapy by inducing...

Really happy to share a link to our work showing that anti-progestin therapy could help prevent breast cancer before menopause.
Published today in Nature, the study suggests this could be a new way to stop breast cancer before it starts: urldefense.com/v3/__https:/...
Brilliant team science

Join me at the ISSCR 2026 Annual Meeting! Register now

There are many ways to make your voice heard and participate in all that #ISSCR2026 has to offer! Discover how to get involved, including submitting an abstract, proposing a science spotlight, hosting a meet-up hub, and more! invt.io/1bxbymmubqq @ISSCR.org

Dynamic allelic expression in mouse mammary glands across the adult developmental cycle Abstract. The mammary gland, which primarily develops postnatally, undergoes significant changes during pregnancy and lactation to facilitate milk producti

🔥🚨 Our new paper is finally out in @narjournal.bsky.social!
academic.oup.com/nar/article/53/17/gkaf804/8248607
We built the first comprehensive atlas of dynamic allelic expression in the mouse mammary gland across adulthood, tracking genes across virgin, #pregnancy, #lactation & #involution.
🧵

In the INAVO120 trial, inavolisib+palbociclib-fulvestrant improved PFS in PIK3CA-mutated, HR+HER2- advanced breast cancer vs placebo+palbociclib-fulvestrant. PMID:40454641, N Engl J Med 2025, @NEJM https://doi.org/10.1056/NEJMoa2501796 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Research Associate Start your career journey at NYU Langone Health, where cutting-edge research meets compassionate, patient-centered care.

We are hiring a research associate in using stem cells and organoid for breast cancer modeling. Please apply jobs.nyulangone.org/job/22446992...
Know more about our ongoing work www.sahulab.com

This has been a dream for years, and I’m grateful to everyone who supported me along the way.
We’re actively recruiting Research Technicians and Postdocs—come build with us! Email for informal inquiries sounak.sahu@nyulangone.org

Thrilled to announce that I’m joining New York University (NYU) Langone Health as an Assistant Professor. We are diving into the world of embryonic stem cells and organoids to unravel how normal development goes right and how it goes wrong in cancer. med.nyu.edu/faculty/soun...

Congratulations @sseethar.bsky.social

Analysis of more than 400,000 women provides case-control evidence for BRCA1 and BRCA2 variant classification - Nature Communications BRCA1 and BRCA2 are well known breast cancer predisposition genes, however, many variants have not yet been classified for their pathogenicity. Here, the authors analyse a large combined cohort to pro...

1/🧬 Excited to share our latest paper in Nature Communications @natcomms.nature.com. We analyzed germline sequencing data from 400,000+ women to strengthen how we classify BRCA1 & BRCA2 variants.
🔗 www.nature.com/articles/s41...
🧵

Proposed cut to NIH for fiscal 2026- $18 billion

www.whitehouse.gov/wp-content/u...

Comprehensive single-cell aging atlas of healthy mammary tissues reveals shared epigenomic and transcriptomic signatures of aging and Cancer. #NatureAging #Aging #scisky #Medsky #News #Cancer

Open Access
www.nature.com/articles/s43...

Saturation genome editing-based clinical classification of BRCA2 variants - Nature CRISPR–Cas9-based saturation genome editing in a humanized mouse embryonic stem cell line was used for comprehensive functional characterization of single nucleotide variants in a region of BRCA2, and...

Excited to share our latest study in
@nature.com We used a humanized-mouse ES cell model to explore the functional consequences of all possible BRCA2 missense variants. We've clinically classified >6,500 variants and >1,200 reported in ClinVar! www.nature.com/articles/s41...

Gut lining in pregnant and lactating mice expands to ensure offspring health The RANK–RANKL pathway promotes intestinal epithelial expansion in pregnancy and lactation to meet increased nutritional demands.

“During pregnancy, several organs are rewired to support the health of the mother and the offspring. A molecular signalling pathway called RANK–RANKL drives the expansion of the layer that lines the inside of the intestine during pregnancy and lactation.”
#ReproSky 🧪
www.nature.com/articles/d41...

I would be interested. Please add me.

A panoramic view of cell population dynamics in mammalian aging To elucidate aging-associated cellular population dynamics, we present PanSci, a single-cell transcriptome atlas profiling over 20 million cells from 623 mouse tissues across different life stages, se...

Excited to share our work @science.org. led by our incredible @tommyz626.bsky.social at @rockefelleruniv.bsky.social! By profiling 21 million single cells across life stages, we reveal aging as distinct, development-like transitions, with dramatic cell population changes in specific time windows!

I would love to join!

I would love to be included - thank you.

A prenatal skin atlas reveals immune regulation of human skin morphogenesis Nature - A comprehensive multi-omics reference atlas of prenatal human skin shows that innate immune cells crosstalk with non-immune cells to perform pivotal roles in skin morphogenesis, including...

Exciting to see the collection of HCA papers out this week in Nature. Honored to be in the mix with our collaboration with @mhaniffa.bsky.social and Sarah Teichmann on a fetal skin atlas. Bravo to Hudaa, Elena, and Bayanne et al, for pulling this study together. A tremendous effort! rdcu.be/d02Yx