Nucleic Acids Research

🎉 Congratulations to HaiyangDong and Yongfeng Jin on their new publication!
An exciting step forward in understanding the complexity of RNA-mediated gene regulation!
👏 Well done to the entire team.

⭐ #NARBreakthrough! ⭐
🧬 New study uncovers how #RNAstructures control stochastic exon selection in Dscam1 genes. #Balancer RNA structures and a #multi-subunit RNA architecture coordinate spatial and temporal splicing 🔬✨
Read the full article here: doi.org/10.1093/nar/...
#AlternativeSplicing

🎉 Congratulations to the first authors, Priyanka Aggarwal and Manmohan Sharma!
Their study in the laboratory of Prof. Karl-Peter Hopfner provides important #mechanistic insight into #chromatin #remodeling across diverse #nucleosomalstates. 🧬🔬 #NARbreakthrough #Chromatin #Epigenetics #INO80

⭐NAR Breakthrough! ⭐
🧬 New #cryo-EM work shows the #humanINO80 motor adapts to DNA unwrapping and can remodel altered particles like #hexasomes - highlighting its versatility across #nucleosome states. 🔬✨ @lmu.de @genecenter-lmu.bsky.social
Read the full article here: doi.org/10.1093/nar/...

#SpinalMuscularAtrophy (SMA) is treated with the ASO Nusinersen (Spinraza™) to restore SMN via SMN2 splicing. 🧬 New work reveals diverse off-target effects linked to its chemistry—and shows how to mitigate them. 🚀
#NARMolecularMedicine #RNATherapeutics #ASO
🔗 Read here: doi.org/10.1093/narm...

Happy to share our paper in collaboration with cancerbits.bsky.social. We used machine learning & ATAC-seq to refine erythroid differentiation protocols. Recipes for lineage differentiation are written on chromatin!

@stanna-ccri.bsky.social @cemm.oeaw.ac.at

Thank you @narjournal.bsky.social for highlighting and appreciating our most research, a method to find efficient differentiation protocols that make the great cells in the lab with less resources and more insight. Do you want to apply this to your favourite cells? Let's talk!

⭐ #NARBreakthrough! ⭐
🔬Using ATAC-seq to measure #chromatin #accessibility, researchers predicted early conditions that would yield successful #differentiation, improve erythroblast production, and identify signals that further boost #efficiency.
@stanna-ccri.bsky.social 📖 doi.org/10.1093/nar/...

🧬 #NARGAB New Research Spotlight
Direct #RNA #nanopore sequencing reveals the most detailed #m6A map to date across Human immunodeficiency virus 1 transcripts #HIV-1. @cnrs.fr @i2bcparissaclay.bsky.social
👉 Read the full paper: doi.org/10.1093/narg...

🔬 New study highlights a novel siRNA polypeptide #nanoparticle targeting TGF β1 and VEGFR2 to overcome ICI resistance in #melanoma. In mice, it cut tumor growth, improved survival, and reduced #metastasis. Read the full article here: doi.org/10.1093/narc...
#NARCAncer #Immunotherapy

🧬 A common ID3 gene variant, rs11574, found in up to 30% of some populations, alters the #ID3protein and disrupts its interaction with E12. ✨ New research shows this change affects gene expression and cell function, offering insight into #diseaserisk. 🔗 Read the paper here: doi.org/10.1093/narm...

⭐ Explore the NARCAN 5th Anniversary Symposium Collection!
🔬 Featuring exciting work on Polθ, HR, PARP inhibitors, emerging targets, and more!
Read here: lnkd.in/ezznFh2f
#NARCancer #DNARepair #CancerResearch #TherapeuticTargets #GenomicInstability

⭐ NARGAB Editor’s Choice: DecoDen integrates multiple epigenomic assays to correct chromatin‑related noise, giving cleaner data and clearer insights.
👉 doi.org/10.1093/narg...
#NARGAB #Epigenetics #Genomics #Bioinformatics #PrecisionMedicine

⭐NAR Breakthrough! ⭐
#RNAtherapeutics show strong promise for #CNSdisorders 🧠. #Preclinical studies reveal that very high doses of #oligonucleotides can cause brief, reversible neuronal activation driven by metal ion interactions 🧪.
Read the full article here: doi.org/10.1093/nar/...

⭐NAR Breakthrough ⭐
New study identifies a 6-nt miR-17 site in the #PKD1 3′UTR that limits PKD1 expression. Targeting this site boosts PKD1 protein and reduces cyst burden in #ADPKD models—highlighting a promising oligo-based strategy @vishal-d-patel.bsky.social
🧬Read more: doi.org/10.1093/nar/...

⭐NAR Breakthrough! ⭐
🚀 ALE RNA platform overcomes length limits in #chemicaRNAsynthesis, enabling >200-nt RNAs. Supports sgRNAs and 5′-capped mRNAs with strong translation and precise mods. Site-specific 2′-OMe poly(A) boosts protein expression. 🧬Read more: doi.org/10.1093/nar/...
#NARBreakthrough

🌟 2026 Nucleic Acids Research Database issue 🧬
182 papers, 84 new databases, plus Breakthrough Articles on JoGo (global long‑read haplotypes) and So3D (3D spatial genomics). Browse the issue and Editorial: academic.oup.com/nar/issue/54...
academic.oup.com/nar/article/...
@danielrigden.bsky.social

⭐NAR Breakthrough! ⭐

🔬 #tRNA modifications fine-tune #translation; in yeast, their loss slows #ribosomes at hard-to-read codon pairs, causing collisions ⚠️, and cells deploy quality control pathways to prevent #proteotoxicstress and ensure survival.
🧬Read more: doi.org/10.1093/nar/...

👏 Congratulations to @helena-stafflinger.bsky.social Helena Stafflinger, @en-hxnu-enment.bsky.social Hermann Schindelin, Jens Wöhnert and their team on this elegant and paradigm-shifting study uncovering unexpected principles of RNA G-quadruplex formation! @uniinnsbruck.bsky.social

⭐NAR Breakthrough! ⭐
🧬 A synthetic RNA forms a #G-quadruplex without a G-rich sequence, using a complex 3D fold and GTP as a ligand. This suggests G-quadruplexes may be far more widespread in biologically important RNAs. Read more: doi.org/10.1093/nar/...

#NARBreaktrhough #RNA #StructuralBiology

🔬 #Trypanosomes process their large rRNA in a highly unusual way-by cutting it into six pieces. A new study from @schneian.bsky.social lab identified two essential proteins, TbLrRP1 and TbLrRP2, that drive this process. Read more: doi.org/10.1093/nar/...
#NARBreakthrough #RibosomeBiogenesis

Congratulations @simrouxvirus.bsky.social
@maureenbug.bsky.social
@titus.idyll.org
@taylorreiter.bsky.social
@ucdavis.bsky.social on this fantastic publication, and thank you for this informative thread!
#NARGenomics #NARGAB #EditorsChoice #GenomeAssembly #Sequencing

DNA repair helicases: from mechanistic understanding to therapeutic implications Abstract. The maintenance of genomic integrity is paramount for normal cell physiology and survival as well as avoidance of carcinogenesis. Cellular DNA is

📢 Read this timely review in #NARCancer! 🧬
Gueble and Menon highlight the critical role of #DNAhelicases in linking #DNAdamage recognition with #repair. The review includes a curated table of #clinicaltrials on #helicaseinhibitors.
Read it here: doi.org/10.1093/narc... @yalepress.bsky.social

We're excited to release metaTraits.embl.de! 🦠 Interactively explore 140+ 𝗺𝗶𝗰𝗿𝗼𝗯𝗶𝗮𝗹 𝗽𝗵𝗲𝗻𝗼𝘁𝘆𝗽𝗶𝗰 𝘁𝗿𝗮𝗶𝘁𝘀, harmonized & integrated from culture-derived collections 🔬 & genome-based predictions 🧬 for >2M MAGs & genomes.

Publication at NAR: doi.org/10.1093/nar/... @narjournal.bsky.social #microsky 🧵 1/8

ChEBI: re-engineered for a sustainable future Abstract. Chemical Entities of Biological Interest (ChEBI) is a high-quality, manually curated, and open-access database and ontology of chemical entities

From one of the @ebi.embl.org team, published in @narjournal.bsky.social #NARDatabaseIssue | ChEBI: re-engineered for a sustainable future | #Bioinformatics #Database #Chemistry #OpenData #OpenScience #ChemicalEntitiesofBiologicalInterest 🧬 🖥️🧪🔓
⬇️
academic.oup.com/nar/advance-...

THRESHOLD: a comprehensive transcriptomic analysis tool for evaluating gene saturation and impact in disease progression Abstract. Gene expression studies are fundamental in molecular biology, offering insights into development, disease progression, and therapeutic targets. T

📢Paper spotlight in NAR Cancer 🧬

A new study in #NARCancer introduces #THRESHOLD, a novel framework that measures gene expression “saturation” 📊—how consistently genes are expressed across cancer patients!

Read the full article here: doi.org/10.1093/narc...
#Transcriptomics #PrecisionOncology

HapScoreDB: a database of protein language model functional scores for haplotype-resolved protein sequences Abstract. Deciphering the functional effects of genetic variants, especially those inherited together on the same haplotype, remains a major challenge in h

🚨 Out in NAR @narjournal.bsky.social!

Introducing HapScoreDB: a database of protein language model functional scores for haplotype-resolved protein sequences.

📄 Paper: doi.org/10.1093/nar/...
💻 DB: bcglab.cibio.unitn.it/hapscoredb

#Bioinformatics #Genomics #ProteinLanguageModels #CompBio

⭐ NAR Breakthrough! ⭐
🦠 New study shows phage X1 hijacks Yersinia's enterocolitica flagellum to inject its DNA directly into the cytosol. Yersinia, though, strikes back!
🦠 A fascinating look at the #dualrole of #flagella in #viralentry and #bacterialimmunity.
🧬 Read more: doi.org/10.1093/nar/...

⭐ NAR Breakthrough! ⭐
🔬 New study reveals how the Retron-Eco7 system helps bacteria sense and fight phage attacks, identifying a clever immune-sensing mechanism in the bacteria–phage arms race.
🧬 Read more: doi.org/10.1093/nar/...
#NARBreakthrough #Microbiology #PhageBiology #BacterialDefense

⭐ NAR Breakthrough! ⭐

🔬 New study by Betancurt et al. uses #PacBio single-molecule sequencing to build a long-read fidelity assay that reveals how different #DNApolymerase families make distinct errors.
🧬 Read more: doi.org/10.1093/nar/...
@nebiolabs.bsky.social @pasteur.fr
#NARBreakthrough