Stabilization of the H5 clade 2.3.4.4b hemagglutinin improves vaccine-elicited neutralizing antibody responses in mice Vaccinating with a stabilized H5 hemagglutinin increases the proportion of humoral responses against neutralizing receptor binding site epitopes.

Stabilization of the H5 clade 2.3.4.4b hemagglutinin improves vaccine-elicited neutralizing antibody responses in mice | Science Translational Medicine www.science.org/doi/10.1126/...

High-resolution in situ structures of hantavirus glycoprotein tetramers New World hantaviruses cause severe infections in humans. Previous structural studies have advanced our understanding of hantavirus glycoprotein archi…

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Parenteral vaccination with an adjuvanted mRNA vaccine induces protective mucosal immunity against rotavirus in neonatal mice An Am80-loaded mRNA-LNP vaccine against rotavirus elicits intestinal mucosal immunity in mice and pigs and protects neonatal mice against infection.

Parenteral vaccination with an adjuvanted mRNA vaccine induces protective mucosal immunity against rotavirus in neonatal mice | Science Translational Medicine www.science.org/doi/10.1126/...

DNA origami vaccines program antigen-focused germinal centers Priming rare subdominant precursor B cells in germinal centers (GCs) is a central goal of vaccination to generate broadly neutralizing antibodies (bnAbs) against HIV. Multivalent immunogen display on ...

DNA origami vaccines program antigen-focused germinal centers | Science www.science.org/doi/10.1126/...

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A potently neutralizing and protective human antibody targeting antigenic site V on RSV and hMPV fusion glycoprotein Abu-Shmais et al. isolate and characterize respiratory syncytial virus (RSV) and human metapneumovirus (hMPV) cross-neutralizing antibodies. Structural analysis reveals one antibody, RM 5-1, binds an ...

A potently neutralizing and protective human antibody targeting antigenic site V on RSV and hMPV fusion glycoprotein: Cell Reports Medicine www.cell.com/cell-reports...

mAbClust with AlphaFold 3 avoids hallucinations to define a quaternary broadly neutralizing HCV epitope The hepatitis C virus (HCV) envelope glycoprotein E1E2 heterodimer is the target of broadly neutralizing antibodies (bNAbs). Although prior studies have indicated that E1-dependent bNAbs are associate...

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A capture assay to analyse immunoglobulin secretion at the single-cell level https://www.biorxiv.org/content/10.64898/2026.01.07.698251v1

Subunit Vaccination Using Atomic Layering Thermostable Antigen and Adjuvant (ALTA®) Platform Elicits Enhanced Humoral and Cellular Immune Responses Creating effective and thermostable vaccines is of significant relevance for public health. The Atomic Layering Thermostable Antigen and Adjuvant (ALTA®) platform combines spray drying to stabilize an...

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Atomic Layering Thermostable Antigen and Adjuvant (ALTA®) platform provides unique antigen delivery system through controlled release to improve immune response to vaccination Prophylactic vaccines are commonly delivered using a multi-dose regimen with the goal of generating potent, durable protection against a specific pathogen. However, the requirement for multiple admini...

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Population-level genomic analysis of immunoglobulin loci variation in rhesus macaques reveals extensive germline diversity Rhesus macaques (RMs) are a vital model for studying human disease and are invaluable to preclinical vaccine research, particularly for the study of b…

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Antigen-agnostic identification of poxvirus broadly neutralizing antibodies targeting OPG153 Antigen-agnostic isolation of B cells enabled the AI-assisted identification of broadly neutralizing antibodies targeting OPG153.

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A vaccine targeting human IgE induces long-term protection against anaphylaxis in humanized mice A conjugate vaccine targeting human IgE induces long-term production of neutralizing antibodies and protects against anaphylaxis in humanized mice.

A vaccine targeting human IgE induces long-term protection against anaphylaxis in humanized mice | Science Translational Medicine www.science.org/doi/10.1126/...

B cells and dengue: A cat-and-mouse game Repeated dengue infections elicit broadly neutralizing antibodies that are protective against severe disease.

B cells and dengue: A cat-and-mouse game | Science Immunology www.science.org/doi/10.1126/...

Antibody feedback establishes an affinity brake in the germinal center Recent advances in mRNA vaccine technology have opened the door to novel types of antigen display, but little is yet known as to how B cells recognize and respond to these formats. By delivering an mR...

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B cells targeting parasites capture spatially linked antigens to secure T cell help Antigen location orchestrates T cell–B cell collaboration in response to large pathogens.

B cells targeting parasites capture spatially linked antigens to secure T cell help | Science Immunology www.science.org/doi/10.1126/...

Highly functional and prolonged germinal center T follicular helper cell responses are associated with enhanced neutralizing antibody development The dynamics of antigen-specific Tfh responses during extended germinal center reactions are not well characterized. Marina-Zárate et al. show that vaccine-specific Tfh cells in the lymph node undergo...

Highly functional and prolonged germinal center T follicular helper cell responses are associated with enhanced neutralizing antibody development: Immunity www.cell.com/immunity/ful...

B cells targeting parasites capture spatially linked antigens to secure T cell help Antigen location orchestrates T cell–B cell collaboration in response to large pathogens.

doi.org/10.1126/scii...

Human coronavirus HKU1 neutralization by glycan receptor mimicry Entry of seasonal human coronavirus HKU1 (HCoV-HKU1) into host cells is facilitated by sequential binding to sialoglycans and transmembrane serine protease 2 (TMPRSS2) receptors. However, the neutrali...

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Antibody-mediated feedback modulates interclonal competition in the germinal center Serum antibodies from prior immune responses regulate B cell activation and germinal center (GC) access upon recall immunization. However, how antibodies produced by an ongoing immune response influen...

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The conserved bridging domain on HCV E1E2 glycoprotein complex is targeted by neutralizing antibodies from diverse lineages The induction of potent and cross-reactive neutralizing antibody (nAb) responses remains a challenge in vaccine development against antigenically diverse viruses such as hepatitis C virus (HCV). The H...

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Atomically accurate de novo design of antibodies with RFdiffusion - Nature The combination of computational design, laboratory-based screening and biophysical validation enables the de novo generation of variable heavy-chain antibody fragments and antibodies that precis...

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Generation of antigen-specific paired-chain antibodies using large language models The traditional process of antibody discovery is limited by inefficiency, high costs, and low success rates. Recent approaches employing artificial in…

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Vaccination-induced T cell responses maintain polyclonality with high antigen receptor avidity Clonal recruitment is governed by a T cell receptor avidity threshold, whereas probabilistic expansion preserves repertoire polyclonality.

Vaccination-induced T cell responses maintain polyclonality with high antigen receptor avidity | Science Immunology www.science.org/doi/10.1126/...

Germinal center–mediated broadening of B cell responses to SARS-CoV-2 booster immunization SARS-CoV-2 variant booster vaccination broadens human B cell responses through the germinal center reaction.

Germinal center–mediated broadening of B cell responses to SARS-CoV-2 booster immunization | Science Immunology www.science.org/doi/10.1126/...

Simultaneous induction of multiple classes of broadly neutralizing antibody precursors by combination germline-targeting immunization in nonhuman primates Simultaneous immunization with three germline-targeting immunogens primes multiple bnAb lineages in NHPs, advancing multiepitope HIV vaccine strategies.

Simultaneous induction of multiple classes of broadly neutralizing antibody precursors by combination germline-targeting immunization in nonhuman primates | Science Immunology www.science.org/doi/10.1126/...

Simultaneous priming of HIV broadly neutralizing antibody precursors to multiple epitopes by germline-targeting mRNA-LNP immunogens in mouse models HIV bNAb precursors to multiple epitopes can be primed by germline-targeting mRNA-LNP immunogens in mouse models.

Simultaneous priming of HIV broadly neutralizing antibody precursors to multiple epitopes by germline-targeting mRNA-LNP immunogens in mouse models | Science Immunology www.science.org/doi/10.1126/...

A replicating RNA vaccine protects cynomolgus macaques against lethal clade 2.3.4.4b influenza A H5N1 virus challenge LION-delivered replicating RNA vaccines are immunogenic and protect cynomolgus macaques against lethal influenza A (H5N1) virus challenge.

A replicating RNA vaccine protects cynomolgus macaques against lethal clade 2.3.4.4b influenza A H5N1 virus challenge | Science Translational Medicine www.science.org/doi/10.1126/...