Just out in @natneuro.nature.com! 🧠
“Competitive interactions shape mammalian brain network dynamics and computation”
www.nature.com/articles/s41...
Is large-scale brain communication purely cooperative — or is competition a core organizing principle?
We built 🧠 models to find out: read on🧵👇
Spatial organization of AQP4 channels in the human brain: links with perfusion, edema, and disease vulnerability | doi.org/10.64898/202...
Aquaporins are a key component of the brain’s glymphatic system. How are they distributed and how do they relate to healthy brain function and dysfunction? ⤵️
Synaptome architecture shapes regional dynamics in the mouse brain | doi.org/10.1371/jour...
How do diverse synapses relate to the spatial patterning of whole-brain dynamics? Justine Hansen explores @plosbiology.org ⤵️
🚀 We are hiring: a PhD position is available in my lab (gozzilab.it) at @iitalk.bsky.social, Italy. Project: large-scale brain network mapping in behaving mice using functional ultrasound imaging (FUSI).
📅 Deadline: March 31
🔗 tinyurl.com/4jtetxa9
Reshares appreciated 😊
Excited to introduce ScaRCaMP — a highly blue-light resistant red GECI. 🔴
Now live on bioRxiv and marking my first PhD preprint (2nd for the Marko lab).
Would love feedback from the community!!
Excited to share our new paper to be published in Neuron!
With Valentin Schmutz @bio-emergent.bsky.social and Wulfram Gerstner @gerstnerlab.bsky.social, we explore how circuit structure in RNNs shapes network computation and single-neuron responses.
www.sciencedirect.com/science/arti...
Once you get past the first 5 minutes of me bumbling around clearly in need of media training, we settle into a nice groove talking about fitting mechanistic models, ML/AI for neuroscience, underconstrainedness vs. degeneracy, and its potential benefits for biology (plus some good chuckles).
fMRI connectivity is dominated by recurring high-amplitude BOLD events (CAPs, QPPs)
But what originates these events? Many think neuromodulation is the culprit. Our new work offers a simpler take: cortico-cortical dynamics alone can generate CAP-like events! doi.org/10.1371/journal.pcbi.1013995
🧵1/n
Spatial organization of AQP4 channels in the human brain: links with perfusion, edema, and disease vulnerability https://www.biorxiv.org/content/10.64898/2026.02.18.706679v1
🚨Do we need a large, expensive MRI scanner to map whole-brain networks in the mouse? Not necessarily!
In our new preprint ▶️ tinyurl.com/3a2h4r9f
we show that transcranial functional ultrasound (fUSI) can map connectome-scale networks with striking agreement to fMRI
🧵👇
We're hiring! This is a unique opportunity to translate our understanding of neural computation - from circuit-level mechanisms to computational principles - into the human brain, through the establishment of cutting-edge human neural recording capabilities with collaborators in London and abroad.
We’re hiring a Group Leader!
Join us to lead a transformative initiative in human systems neuroscience.
Find out more and apply ⤵️
www.sainsburywellcome.org/content/curr...
Inter-individual variability of neurotransmitter receptor and transporter density in the human brain | doi.org/10.1007/s004...
How do neuroreceptor distributions vary across people?
Left: Pathways involved in brain energy metabolism. Energy metabolism refers to processes involved in energy production from nutrient molecules. Glucose is the main energy source in the brain under normal physiological conditions. Glucose entering brain cells can be utilized in three parallel pathways. It can be processed through glycolysis to produce 2 ATP and 2 pyruvate molecules (blue). Lactate dehydrogenases catalyze the interconversion of lactate and pyruvate (purple). Pyruvate is transported into mitochondria, where it enters the TCA cycle to generate high-energy electron carriers NADH and FADH2 (green), driving the complete oxidation of glucose through the mitochondrial electron transport chain (red). Glucose entering the brain can also enter the PPP. PPP is an anabolic pathway that uses glucose to produce 5-carbon sugars and NADPH, an essential co-factor used in nucleotide and lipid biosynthesis (yellow). Glucose can also be stored in the form of glycogen via glycogen synthase, a process mainly active in astrocytes. Right: Energy pathway maps. Colors show z-scored mean expression values across all genes in each pathway. ppp, pentose phosphate pathway; tca, tricarboxylic acid cycle; oxphos, oxidative phosphorylation; lactate, lactate metabolism and transport.
How are energy #metabolism pathways distributed across the #cortex? @alaindagher.bsky.social &co map five pathways in the human #brain, linking metabolic organization with brain structural & functional properties, as well as developmental dynamics @plosbiology.org 🧪 plos.io/4c1JVp8
Luppi et al. identify transcriptomic and connectomic controllers of information integration and its breakdown induced by anaesthesia across species
netneurotools: a trainee-oriented approach to network neuroscience | doi.org/10.1101/2025...
Our lab’s internal toolkit for accomplishing everyday tasks in brain imaging ⤵️
BOLD signal changes can oppose oxygen metabolism across the human cortex, Nature Neuroscience
fMRI signals “up,” but neural metabolism might be going “down.”
In our @natneuro.nature.com paper, we demonstrate that about 40% of voxels with robust BOLD responses exhibit opposite oxygen metabolism, revealing two distinct hemodynamic modes.
rdcu.be/eUPO8
funds @erc.europa.eu
#neuroskyence 🧵:
It's happening! Canada launched two programs to recruit international researchers.
Canada Impact+ Research Chairs (1 million/yr for 8 yrs +)
Canada Impact+ Emerging Leaders.
I will do my best to facilitate the process for those interested. Hit me up.
www.canada.ca/en/impact-pl...
🧠 Excited to share our latest preprint: Automated Brain Mapping with AI Experts!🤖
www.biorxiv.org/content/10.6...
Ever wanted to summarise the cognitive/systems neuroscience literature beyond MRI and PET? Ever wished we could do the same for macaque 🐒 and mouse 🐭 ? Read on! 🧵👇
Truly honored to be recognized among @thetransmitter.bsky.social's Rising Stars of Neuroscience for 2025 next to trailblazers like @valeriejsydnor.bsky.social, @lindenmp.bsky.social, @elimuller.bsky.social & more!🌟🧠Check out everyone's full contributions at www.thetransmitter.org/early-career...
I am recruiting graduate students for the experimental side of my lab @mcgill.ca for admission in Fall 2026!
Get in touch if you're interested in how brain circuits implement distributed computation, including dopamine-based distributed RL and probabilistic representations.
I am super happy to share that our project on training biophysical models with Jaxley is now published in Nature Methods: www.nature.com/articles/s41...
Preprint -
Excited to present WHOLISTIC, which extends the concept of whole-brain functional imaging to the entire body. Pioneering work by incredibly talented Virginia Ruetten @vmsruetten.bsky.social, this platform reveals whole-organism cellular dynamics in vivo.
www.biorxiv.org/content/10.1...
Our recent work on spin tests is now published in Imaging Neuroscience🎉
As always, the code to reproduce our results and figures is available on github: github.com/netneurolab/...
The effect of spherical projections on spin tests for brain maps | doi.org/10.1162/IMAG...
Spin tests are the de facto null model for map-to-map comparisons in brain imaging. Why don't they perfectly control false positives? @vincebaz.bsky.social explores ⤵️
Integrating and interpreting brain maps | doi.org/10.1016/j.ti...
Imaging and recording technologies make it possible to map multiple biological features of the brain. How can these features be conceptually integrated into a coherent understanding of brain structure and function? ⤵️
Normative blood perfusion map on lateral and medial views of the inflated and 2D flat cortical surfaces (fsLR). Borders and areal names of the multi-modal Glasser parcellation are overlaid on the flat surface. The figure highlights the non-uniform distribution of perfusion scores across the cortex, with areas that have sharp gradient compared to their underlying perfusion score levels (e.g., LIPv and MT/MST).
How does cerebral #BloodPerfusion map onto micro-, meso- & macro-scale brain structure? @asafarahani.bsky.social @misicbata.bsky.social &co characterize blood perfusion in the #HumanBrain, revealing how it changes with age & in #NeurodegenerativeDisease @plosbiology.org 🧪 plos.io/46AEURS
🧬🧠 Our latest study shows that individual brain dynamics are partly written in our genes. We found that heritable neurophysiological traits align with adult cortical gene expression and psychological function.
www.science.org/doi/10.1126/...
@theneuro.bsky.social @mcgill.ca
New paper in Imaging Neuroscience by Nikhil Bhagwat, Yu-Fang Yang, et al:
Challenging the status quo: A guide to open and reproducible neuroimaging for early career researchers
doi.org/10.1162/IMAG...
An Analysis of 200 pairwise statistics for functional brain connectivity in tasks such as hub mapping, distance relationships, structure-function coupling and behavior prediction highlights their effectiveness for neurophysiological applications.
www.nature.com/articles/s41...
New: Energy use shapes brain organization and development. We use gene expression maps from the @alleninstitute.bsky.social Human Brain Atlas to map the main energy metabolism pathways in the brain. Led by @moohebatpe.bsky.social @misicbata.bsky.social @goliashf.bsky.social and Justine Hansen 🧵
