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Art block has been beating me black and blue [ #art #fanart #kyn ]

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More😠 [ #art #fanart #kyn ]

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Dec 25 2025 [ #art #fanart #kyn #demonslayer ] lower quality because of smaller canvas size.

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I drew my Demon slayer sona's headshot in the style of @sunnydrawzzz.bsky.social

I hope you don't mind hbfdjg (I really admire your work hbfngjdngb)

#demonslayer⚔️ #kyn #animefanarts #sketchart #digitalartist
(the hashira was drawn by sunny)

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A redraw of a frame from the anime demon slayer of Gyutaro, upper moon six, with his sickles out and scratching at himself.

A redraw of a frame from the anime demon slayer of Gyutaro, upper moon six, with his sickles out and scratching at himself.

>>• #demonslayer #kimetsunoyaiba #kyn

This was my most popular art on X!! I hope you all like it too!!

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A custom screenshot of twitter dms where I edited it to look like my favorite characters for yumeships dming me

Yuji Itatdori @Itatigerdaifists
Wanna see me rizz you up? PLEASE PLEASE PLEASE PLEASE PLEA

Yuta Okkotsu @PureLoveGuy
Hello! Does October 31st 2018 mean anything to you?

Denji @NotChainsawMan
Yo herd ur a fan(sunglasses emoji)

Pochita @LittleGuyChainSilly
Vaaggh! Vaaahhh!! Vaaammmnnnn~~(lip bite emoji, smirk emoji, tipsy emoji)

Gyutaro Shabana @KingUglyUpper6
I accidentally dm'd u ignore this, I just stalk ur page

Miss Makima @JPSBDIRECTORMAKIMA
KILL YOURSELF

A custom screenshot of twitter dms where I edited it to look like my favorite characters for yumeships dming me Yuji Itatdori @Itatigerdaifists Wanna see me rizz you up? PLEASE PLEASE PLEASE PLEASE PLEA Yuta Okkotsu @PureLoveGuy Hello! Does October 31st 2018 mean anything to you? Denji @NotChainsawMan Yo herd ur a fan(sunglasses emoji) Pochita @LittleGuyChainSilly Vaaggh! Vaaahhh!! Vaaammmnnnn~~(lip bite emoji, smirk emoji, tipsy emoji) Gyutaro Shabana @KingUglyUpper6 I accidentally dm'd u ignore this, I just stalk ur page Miss Makima @JPSBDIRECTORMAKIMA KILL YOURSELF

A screenshot from twitter dms of all of the bots trying to scam and talk to me

A screenshot from twitter dms of all of the bots trying to scam and talk to me

>>• #jjk #csm #kyn

Made this right before I left twitter! Lol

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#Tryptophan’s fate 🔥 decides between #Mood 🧠, #Cancer ⚖️, or #Neurodegeneration!🧬Our study exposes #KYN checkpoints⚡ shaping the #Gut#Brain axis!
#NeuroImmunity #Kynurenine @mdpiopenaccess.bsky.social
👉 www.mdpi.com/2227-9059/13...

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Closed-loop🚀“smart protocols”: #Biomarker-guided combos🌀of #Lifestyle 💊, chrono-dosing🧫, & #Bioengineered #Microbes ! ✨A new era for #KYN control!
#SyntheticBiology #NeuroTherapeutics
@mdpiopenaccess.bsky.social
👉 www.mdpi.com/2227-9059/13...

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🚀 “UHPLC-MS/MS unravels the first detailed #KYN metabolite map in progressive #MS-like mice! 🧠🧪🌈
A leap toward personalized MS diagnostics and smarter therapy!💥💡
👉Read, share & rethink MS progression!🔗📊 @mdpiopenaccess.bsky.social
#Biomarkers #Innovation #Neuroscience
doi.org/10.3390/biom...

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We found #KYN bottlenecks💡in #Microglia 🧠+ #Endothelial cells🧪, revealing synergy🧬points for dual #Inhibitors 🌐+engineered #Probiotics!@mdpiopenaccess.bsky.social #Metabolomics #BrainHealth
👉 www.mdpi.com/2227-9059/13...

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#Tryptophan’s fate 🔥 decides between #Mood 🧠, #Cancer ⚖️, or #Neurodegeneration!🧬Our study exposes #KYN checkpoints⚡ shaping the #Gut#Brain axis!
#NeuroImmunity #Kynurenine @mdpiopenaccess.bsky.social
👉 www.mdpi.com/2227-9059/13...

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Genya's proper punishment for eating demons~

Did prompts from the first three days of kinktober! Incest, Kidnapping, and Nipple Clamps! 🔥

#kinktober #demonslayer #incest #genya #sanemi #nsfw #animeporn #yaoi #nsfwart #kyn

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🧪 #Future #Ttherapy? Balance the whole #KYN pathway⚖️, not just block 1 metabolite!🌍 Context > labels🧠✨ @mdpiopenaccess.bsky.social #PrecisionMedicine #FutureOfHealth
💬 Debate + 🔄 Share 👉 www.mdpi.com/1422-0067/25...

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Closed-loop🚀“smart protocols”: #Biomarker-guided combos🌀of #Lifestyle 💊, chrono-dosing🧫, & #Bioengineered #Microbes ! ✨A new era for #KYN control!
#SyntheticBiology #NeuroTherapeutics
@mdpiopenaccess.bsky.social
👉 www.mdpi.com/2227-9059/13...

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✨ New insights reveal: #KYN metabolites switch roles like double agents— #Antioxidant 🛡️or #Pro-oxidant 🔥 depending on the cellular stage. #Neuropsychiatry #Medicine 🚀 Read & share! @mdpiopenaccess.bsky.social #Alzheimers #MS #Cancer
Share to spark debate!💬 www.mdpi.com/1422-0067/25...

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We found #KYN bottlenecks💡in #Microglia 🧠+ #Endothelial cells🧪, revealing synergy🧬points for dual #Inhibitors 🌐+engineered #Probiotics! @mdpiopenaccess.bsky.social #Metabolomics #BrainHealth
👉 www.mdpi.com/2227-9059/13...

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🤔What if the same #Molecule that protects your brain could also destroy it? The #Tryptophan#KYN pathway isn’t black & white!⚖️ @mdpiopenaccess.bsky.social #Neuroscience #Kynurenine #BrainHealth #Innovation
www.mdpi.com/2227-9059/13...

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From Microbial Switches to Metabolic Sensors: Rewiring the Gut–Brain Kynurenine Circuit The kynurenine (KYN) metabolic pathway sits at the crossroads of immunity, metabolism, and neurobiology, yet its clinical translation remains fragmented. Emerging spatial omics, wearable chronobiology, and synthetic microbiota studies reveal that tryptophan (Trp) metabolism is regulated by distinct cellular “checkpoints” along the gut–brain axis, finely modulated by sex differences, circadian rhythms, and microbiome composition. However, current interventions tackle single levers in isolation, leaving a key gap in the precision control of Trp’s fate. To address this, we drew upon an extensive body of the primary literature and databases, mapping enzyme expression across tissues at single-cell resolution and linking these profiles to clinical trials investigating dual indoleamine 2,3-dioxygenase 1 (IDO1)/tryptophan 2,3-dioxygenase (TDO) inhibitors, engineered probiotics, and chrono-modulated dosing strategies. We then developed decision-tree algorithms that rank therapeutic combinations against biomarker feedback loops derived from real-time saliva, plasma, and stool metabolomics. This synthesis pinpoints microglial and endothelial KYN hotspots, quantifies sex-specific chronotherapeutic windows, and identifies engineered Bifidobacterium consortia and dual inhibitors as synergistic nodes capable of reducing immunosuppressive KYN while preserving neuroprotective kynurenic acid. Here, we highlight a framework that couples lifestyle levers, bio-engineered microbes, and adaptive pharmaco-regimens into closed-loop “smart protocols.” By charting these intersections, this study offers a roadmap for biomarker-guided, multidisciplinary interventions that could recalibrate KYN metabolic activity across cancer, mood, neurodegeneration, and metabolic disorders, appealing to clinicians, bioengineers, and systems biologists alike.

🤔What if the same #Molecule that protects your brain could also destroy it? The #Tryptophan#KYN pathway isn’t black & white!⚖️ @IJMS_MDPI @MDPIOpenAccess #Neuroscience #Kynurenine #BrainHealth #Innovation
www.mdpi.com/2227-9059/13...

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From Microbial Switches to Metabolic Sensors: Rewiring the Gut–Brain Kynurenine Circuit The kynurenine (KYN) metabolic pathway sits at the crossroads of immunity, metabolism, and neurobiology, yet its clinical translation remains fragmented. Emerging spatial omics, wearable chronobiology, and synthetic microbiota studies reveal that tryptophan (Trp) metabolism is regulated by distinct cellular “checkpoints” along the gut–brain axis, finely modulated by sex differences, circadian rhythms, and microbiome composition. However, current interventions tackle single levers in isolation, leaving a key gap in the precision control of Trp’s fate. To address this, we drew upon an extensive body of the primary literature and databases, mapping enzyme expression across tissues at single-cell resolution and linking these profiles to clinical trials investigating dual indoleamine 2,3-dioxygenase 1 (IDO1)/tryptophan 2,3-dioxygenase (TDO) inhibitors, engineered probiotics, and chrono-modulated dosing strategies. We then developed decision-tree algorithms that rank therapeutic combinations against biomarker feedback loops derived from real-time saliva, plasma, and stool metabolomics. This synthesis pinpoints microglial and endothelial KYN hotspots, quantifies sex-specific chronotherapeutic windows, and identifies engineered Bifidobacterium consortia and dual inhibitors as synergistic nodes capable of reducing immunosuppressive KYN while preserving neuroprotective kynurenic acid. Here, we highlight a framework that couples lifestyle levers, bio-engineered microbes, and adaptive pharmaco-regimens into closed-loop “smart protocols.” By charting these intersections, this study offers a roadmap for biomarker-guided, multidisciplinary interventions that could recalibrate KYN metabolic activity across cancer, mood, neurodegeneration, and metabolic disorders, appealing to clinicians, bioengineers, and systems biologists alike.

#Tryptophan’s fate 🔥 decides between #Mood 🧠, #Cancer ⚖️, or #Neurodegeneration!🧬Our study exposes #KYN checkpoints⚡ shaping the #Gut#Brain axis!
#NeuroImmunity #Kynurenine @mdpiopenaccess.bsky.social
👉 www.mdpi.com/2227-9059/13...

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🧠💥Fighting #Neurodegeneration?
🌿Rethink the #KYN pathway⚖️
🔄Balance= #Breakthrough #Therapies 💡💪 @mdpiopenaccess.bsky.social #Neuroscience
🚀 The #Shift starts here → www.mdpi.com/1422-0067/25...

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🔍🤔Flip the #KYN switch to reboot immunity, metabolism & mood? 🧠🛠️We mapped cell checkpoints, chrono windows & #Probiotic+IDO/TDO combos that cut KYN & spare #KYNA🚀 @mdpiopenaccess.bsky.social #PrecisionMedicine #Microbiome #Chronotherapy 👉 Read & share! www.preprints.org/manuscript/2...

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🌱To treat #Neurodegenerative diseases, we must rethink #KYN metabolites⚖️💡 Balancing these pathways could unlock new, effective therapies. Ready for the shift? 🔄💪 @mdpiopenaccess.bsky.social #Neuroscience #Breakthroughs #MedicalResearch #HealthInnovation
www.mdpi.com/1422-0067/25...

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🤔 Could #KYN flip from hero to villain?
🛡️ Low doses= #Neuroprotective
☠️ High doses=toxic
#Redox state dictates its role
🔍Time for context-driven #Therapies in #Alzheimer’s #MS & #Cancer! @mdpiopenaccess.bsky.social #Neuroscience #Kynurenine #Neurodegeneration
www.mdpi.com/1422-0067/25...

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🔍🤔Flip the #KYN switch to reboot immunity, metabolism & mood? 🧠🛠️We mapped cell checkpoints, chrono windows & #Probiotic+IDO/TDO combos that cut KYN & spare #KYNA🚀 @mdpiopenaccess.bsky.social #PrecisionMedicine #Microbiome #Chronotherapy 👉 Read & share! www.preprints.org/manuscript/2...

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🤔 Could #KYN flip from hero to villain?
🛡️ Low doses= #Neuroprotective
☠️ High doses=toxic
#Redox state dictates its role
🔍Time for context-driven #Therapies in #Alzheimer’s #MS & #Cancer! @mdpiopenaccess.bsky.social #Neuroscience #Neurodegeneration #Immunometabolism
www.mdpi.com/1422-0067/25...

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🔍🤔Flip the #KYN switch to reboot immunity, metabolism & mood? 🧠🛠️We mapped cell checkpoints, chrono windows & #Probiotic+IDO/TDO combos that cut KYN & spare #KYNA🚀 @mdpiopenaccess.bsky.social #PrecisionMedicine #Microbiome #Chronotherapy 👉 Read & share! www.preprints.org/manuscript/2...

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🔍🤔Flip the #KYN switch to reboot immunity, metabolism & mood? 🧠🛠️We mapped cell checkpoints, chrono windows & #Probiotic+IDO/TDO combos that cut KYN & spare #KYNA🚀 @mdpiopenaccess.bsky.social #PrecisionMedicine #Microbiome #Chronotherapy
👉 Read & share! www.preprints.org/manuscript/2...

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🤔Could #KYN flip from hero to villain?
🛡️Low doses= #Neuroprotective
☠️High doses=toxic
#Redox state dictates its role
🔍Time for context-driven #Therapies in #Alzheimer’s #MS & #Cancer! @mdpiopenaccess.bsky.social
#Neuroscience #Kynurenine #Neurodegeneration
www.mdpi.com/1422-0067/25...

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🔍🤔Flip the #KYN switch to reboot immunity, metabolism & mood? 🧠🛠️We mapped cell checkpoints, chrono windows & #Probiotic+IDO/TDO combos that cut KYN & spare #KYNA🚀 @mdpiopenaccess.bsky.social #PrecisionMedicine #Microbiome #Chronotherapy
👉 Read & share! www.preprints.org/manuscript/2...

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🧠💥Fighting #Neurodegeneration?
🌿Rethink the #KYN pathway⚖️
🔄Balance= #Breakthrough #Therapies 💡💪 @mdpiopenaccess.bsky.social #Neuroscience
🚀 The #Shift starts here → www.mdpi.com/1422-0067/25...

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