Nature Neuroscience

Check out our March issue!

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Associate or Senior Editor, Nature Neuroscience Job Title: Associate or Senior Editor, Nature Neuroscience Locations: Madrid, Shanghai and Pune Application Deadline: March, 9th 2026 candidates will be considered as they apply About Springer Nature ...

🚨We're hiring a new editor!🚨

We're especially looking for someone with expertise in neurodegeneration and cellular/molecular neuroscience. Must have a Ph.D. and be able to work from Madrid, Shanghai, or Pune. Deadline to apply is March 9.

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Explore our January issue!

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Frameshift: Shari Wiseman reflects on her pivot from science to publishing As chief editor of Nature Neuroscience, Wiseman applies critical-thinking skills she learned in the lab to manage the journal’s day-to-day operations.

Check out “Frameshift,” a Q&A series in which neuroscientists with nontraditional careers discuss their work and how they made the transition away from the lab. In the first entry of the series, @shariwiseman.bsky.social shares how she went from the bench to science publishing.

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Don't sleep on our December issue!

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Connectome caricatures remove large-amplitude coactivation patterns in resting-state fMRI to emphasize individual differences - Nature Neuroscience Dominant coactivation patterns are primarily studied in resting-state fMRI. Here, the authors study the rest of the signal, which reveals ‘caricatured’ connectomes with improved behavioral prediction.

Connectome caricatures remove large-amplitude coactivation patterns in resting-state fMRI to emphasize individual differences

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Laser-engineered PRIME fiber for panoramic reconfigurable control of neural activity - Nature Neuroscience The authors develop a neural probe with over 1,000 light emitters arranged along its length and circumference, enabling panoramic 3D optical stimulation across large brain volumes.

Laser-engineered PRIME fiber for panoramic reconfigurable control of neural activity

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Specialized structure of neural population codes in parietal cortex outputs - Nature Neuroscience Cortical neurons comprising an output pathway form a specialized population code that enhances the propagation of information to a downstream target, potentially improving the accuracy of decision-mak...

Parietal cortex output neurons form a specialized population code that enhances the propagation of information to a downstream target and potentially improves the accuracy of decision-making

www.nature.com/articles/s41...

Chief Editor Shari Wiseman @shariwiseman.bsky.social will be at the @springernature.com booth (#2220, look for the picture of a woman rock-climbing) from 2-4 today and from 10-12 tomorrow. Come stop by!

#SfN2025

TDP-43-dependent mis-splicing of KCNQ2 triggers intrinsic neuronal hyperexcitability in ALS/FTD - Nature Neuroscience TDP-43 dysfunction in ALS/FTD causes faulty splicing of the KCNQ2 ion channel, leading to toxic protein buildup, neuron hyperactivity and a potential new biomarker and treatment target using RNA-based...

TDP-43-dependent mis-splicing of KCNQ2 triggers intrinsic neuronal hyperexcitability in ALS/FTD

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Chief Editor Shari Wiseman @shariwiseman.bsky.social will be at the @sfn.org meeting! She'll be at the @springernature.com booth (#2220) from 2-4 pm on Sunday and Tuesday, and from 10 am-12 pm on Monday and Wednesday. If you’d like to set up a one-on-one meeting, please email her.

#SfN2025

Attentional failures after sleep deprivation are locked to joint neurovascular, pupil and cerebrospinal fluid flow dynamics - Nature Neuroscience Yang et al. show that moments of failed attention we experience after sleep deprivation reflect brief ‘sleep-like’ episodes in the brain, corresponding to a brain- and body-wide event with altered bra...

Attentional failures during wakefulness after sleep deprivation are tightly orchestrated in a series of brain–body changes, including neuronal shifts, pupil constriction and cerebrospinal fluid (CSF) flow pulsations

@lauradata.bsky.social @ziy027.bsky.social

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🥳Please join us in welcoming Ana Uzquiano @uzquianoa.bsky.social to our editorial team! Ioana is handling transcriptomics, neurodevelopment, and cellular and molecular neuroscience. She's based in the Madrid office.

Falling asleep follows a predictable bifurcation dynamic - Nature Neuroscience Li et al. propose a conceptual framework to study the phenomenon of falling asleep based on electroencephalogram data. They show that a tipping point marks the brain’s nonlinear wake-to-sleep transiti...

The brain’s wake-to-sleep transition follows bifurcation dynamics with a distinct tipping point preceded by a critical slowing down

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Prediction of neural activity in connectome-constrained recurrent networks - Nature Neuroscience The authors show that connectome datasets alone are generally not sufficient to predict neural activity. However, pairing connectivity information with neural recordings can produce accurate predictio...

Connectome datasets alone are generally not sufficient to predict neural activity. However, pairing connectivity information with neural recordings can produce accurate predictions of activity in unrecorded neurons

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Longitudinal measures of monkey brain structure and activity through adolescence predict cognitive maturation - Nature Neuroscience Working memory improves during adolescent brain development. Zhu et al. tracked monkeys through adolescence, revealing that maturation of white matter tracts and refinement of neural firing patterns s...

Longitudinal measures of monkey brain structure and activity through adolescence predict cognitive maturation

@cconstan.bsky.social

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The neuronal chromatin landscape in brains from individuals with schizophrenia is linked to early fetal development - Nature Neuroscience This study maps chromatin accessibility in neurons and glia in schizophrenia, revealing fetal-like regulatory patterns in adult neurons enriched for genetic risk variants, linking early brain developm...

Large-scale chromatin accessibility profiling (ATAC-seq) of neurons and non-neurons from 2 human neocortical regions from 469 unique donors, comprising controls and individuals diagnosed with schizophrenia and bipolar disorder

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Cortical and subcortical mapping of the human allostatic–interoceptive system using 7 Tesla fMRI - Nature Neuroscience The brain is constantly monitoring the systems in the body. Here the authors use 7 Tesla functional magnetic resonance imaging to map a large-scale brain system for body regulation in humans, includin...

Cortical and subcortical mapping of the human allostatic–interoceptive system using 7 Tesla fMRI

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Our November issue is now live!

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A glial circadian gene expression atlas reveals cell-type and disease-specific reprogramming in response to amyloid pathology or aging - Nature Neuroscience Sheehan et al. have characterized the circadian translatomes of astrocytes and microglia in the mouse cortex in the context of amyloid pathology or aging, revealing cell- and disease-specific reprogra...

Characterization of the circadian translatomes of astrocytes and microglia in mouse cortex in the setting of amyloid pathology or aging, revealing cell and disease-specific circadian reprogramming of neurodegeneration-related pathways

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TDP-43 loss brings RNA to a twist ending - Nature Neuroscience In amyotrophic lateral sclerosis (ALS), nuclear depletion and cytoplasmic aggregation of the RNA-binding protein TDP-43 cause widespread dysregulation of mRNA splicing. Two recent studies have now rev...

And, check out this News & Views on both pieces

www.nature.com/articles/s41...

TDP-43 loss induces cryptic polyadenylation in ALS/FTD - Nature Neuroscience The authors find that TDP-43 loss of function—the pathology defining the neurodegenerative conditions ALS and FTD—induces novel mRNA polyadenylation events, which have different effects, including an ...

And this one from Pietro Fratta's group

www.nature.com/articles/s41...

TDP-43 nuclear loss in FTD/ALS causes widespread alternative polyadenylation changes - Nature Neuroscience Zeng et al. show that TDP-43, known for repressing cryptic exon usage in frontotemporal dementia/amyotrophic lateral sclerosis, also controls alternative polyadenylation, impacting expression of disea...

A pair of papers on how TDP-43 loss in ALS/FTD causes changes in mRNA polyadenylation

This one from Aaron Gitler's group

www.nature.com/articles/s41...

A lateral hypothalamic neuronal population expressing leptin receptors counteracts anxiety to enable adaptive behavioral responses - Nature Neuroscience Figge-Schlensok et al. show that leptin-sensitive neurons in the lateral hypothalamus encode anxiogenic stimuli and facilitate adaptive strategies to enable an animal to overcome anxiety in threatenin...

Leptin-sensitive neuronal subpopulations in the lateral hypothalamus enable adaptive fulfillment of vital needs despite anxiogenic conditions

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Oxytocin modulates respiratory heart rate variability through a hypothalamus–brainstem–heart neuronal pathway - Nature Neuroscience Buron et al. show that oxytocin enhances heart rate variability linked to breathing during recovery from stress. This calming and cardio-protective effect is produced through a hypothalamus–brainstem ...

Oxytocin modulates respiratory heart rate variability through a hypothalamus–brainstem–heart neuronal pathway

@julie.buron.bsky.social @inmed.bsky.social @insermpacacorse.bsky.social D54@incia-neurocampus.bsky.social

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🥳Please join us in welcoming Ioana Marin to our editorial team! Ioana is handling neuroimmunology and cellular and molecular neuroscience. She's based in the NYC office.

Differential synaptic depression mediates the therapeutic effect of deep brain stimulation - Nature Neuroscience The authors show that deep brain stimulation (DBS) inhibits local neural activity via differential suppression of glutamate and GABA release, and they developed a chemogenetic therapy as a less invasi...

High-frequency deep brain stimulation (DBS) of the subthalamic nucleus (STN), a common target for Parkinson’s disease, activates afferent axons while inhibiting STN neurons

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Region-specific drivers of CSF mobility measured with MRI in humans - Nature Neuroscience Brain clearance mechanisms are challenging to visualize in humans. Using magnetic resonance imaging, the authors noninvasively mapped cerebrospinal fluid motion across the brain, showing region-specif...

A noninvasive, CSF-specific MRI technique that enables detailed in vivo measurement of CSF mobility in humans, down to the level of perivascular spaces located around penetrating vessels

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C9orf72 hexanucleotide repeat expansions impair microglial response in ALS - Nature Neuroscience This study shows that C9orf72 mutations impair immune activation in ALS, affecting how brain cells communicate, and highlights key differences in the cellular and molecular pathways underlying sporadi...

C9orf72 mutations impair immune activation in ALS, highlighting key differences in the cellular and molecular pathways underlying sporadic and genetics forms of the disease

@mancusorenzo.bsky.social @c9laura72.bsky.social @baukje-bij.bsky.social @cmn-vib.bsky.social

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Nature Neuroscience is happy to now offer Transparent Peer Review, in which authors can choose for us to publish details about the peer review process (including reviews, rebuttal letters, and editorial decision letters). More info at the link below:

www.nature.com/neuro/editor...